Výsledky vyhledávání - "Marzia Harnois"

A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification

Autor: Filippo de Marinis, Karim Rihawi, Analia Azaro, Marzia Harnois, Alice Hervieu, Antoine Hollebecque, Gianluca Spitaleri, Corinne Gomez, Nicolas Isambert, Sylvie Assadourian, Victor Moreno, Stefania Salvagni, Katia Fiorella Dotti, Eric Angevin, Jordi Rodon

Publikováno v: European Journal of Cancer. 87:131-139

Purpose Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was investigated in patients with advanced solid tumours and MET dysregulation. Methods This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cc7399371061a1e3a7125f5706c7b3
https://doi.org/10.1016/j.ejca.2017.10.016

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Phase I dose-escalation study of the c-Met tyrosine kinase inhibitor SAR125844 in Asian patients with advanced solid tumors, including patients with MET-amplified gastric cancer

Autor: Hyo Song Kim, Sylvie Assadourian, Tomoya Yokota, Taroh Satoh, Masahiro Goto, Satoshi Hamauchi, Tae Min Kim, Kohei Shitara, Yung-Jue Bang, Marzia Harnois, Toshihido Doi, Corinne Gomez, Toshihiro Kudo, Jin-Hee Ahn

Publikováno v: Oncotarget. 8:79546-79555

// Kohei Shitara 1 , Tae Min Kim 2 , Tomoya Yokota 3 , Masahiro Goto 4 , Taroh Satoh 5 , Jin-Hee Ahn 6 , Hyo Song Kim 7 , Sylvie Assadourian 8 , Corinne Gomez 9 , Marzia Harnois 8 , Satoshi Hamauchi 3 , Toshihiro Kudo 5 , Toshihido Doi 1 and Yung-Jue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67c57b96737a9a8ad6790ee2b48647b7
https://doi.org/10.18632/oncotarget.18554

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Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture

Autor: Florence Fassy, Yvette Taburet, Caroline Peneff, V. Zamboni, Jacques Winter, Paul Ferrari, Véronique Charrier, Marzia Harnois, Yves Bourne, Célia Monnier

Publikováno v: The EMBO Journal. 20:6191-6202

The recently published human genome with its relatively modest number of genes has highlighted the importance of post-transcriptional and post-translational modifications, such as alternative splicing or glycosylation, in generating the complexities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3a50e771215318b3617f4bd9fa3b5d
https://doi.org/10.1093/emboj/20.22.6191

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Abstract A167: A phase I study of MET TKI SAR125844 in Asian patients (pts) with advanced solid tumors

Autor: Toshihiko Doi, Do-Youn Oh, Jin-Hee Ahn, Tae Won Kim, Tomoya Yokota, Kohei Shitara, Yung-Jue Bang, Satoshi Hamauchi, Marzia Harnois, Corinne Gomez

Publikováno v: Molecular Cancer Therapeutics. 14:A167-A167

Background: SAR125844 (SAR) is a potent and small molecule inhibitor of the MET kinase (IC50 = 4.2nM; Ki = 2.8nM). This phase I study (NCT01657214) was initiated to address the maximum tolerated dose (MTD), safety, pharmacokinetics (PK), pharmacodyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::299d0b2f623cbd21f050d9ff8dc1b89a
https://doi.org/10.1158/1535-7163.targ-15-a167

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A first-in-human (FIH) phase I study of SAR125844, a novel selective MET kinase inhibitor, in patients (pts) with advanced solid tumors: Dose escalation results

Autor: Jean-Charles Soria, Filippo de Marinis, Tommaso De Pas, Marzia Harnois, Antoine Hollebecque, Gianluca Spitaleri, Eric Angevin, Florent Mazuir, Sylvie Assadourian

Publikováno v: Journal of Clinical Oncology. 32:2506-2506

2506 Background: SAR125844 (SAR) is a potent and highly selective MET kinase inhibitor (IC50= 4.2 nM; Ki = 2.8 nM) demonstrated to be effective in MET-driven tumors with a good safety and pharmacok...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f404eab31f0c24ce1e0da7fa5b6a001f
https://doi.org/10.1200/jco.2014.32.15_suppl.2506

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Synthesis and biological activities of some endothelin analogs

Autor: Marzia Harnois, Michel Fortin, Simone Jouquey, Gilles Hamon, Eve Mahe, Bernard Schoot, Dung Le-Nguyen

Publikováno v: Peptides 1992 ISBN: 9789401046466
Peptides 1992

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https://doi.org/10.1007/978-94-011-1470-7_311

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Hydrosoluble fluorogenic substrates for plasmin

Autor: Marzia Harnois-Pontoni, Roger Mayer, Michel Monsigny

Publikováno v: Analytical biochemistry. 193(2)

New hydrosoluble fluorogenic substrates for plasmin gluconoylpeptidyl-3-amido-9-ethylcarbazole were synthesized. The substitution of the N-terminal end of the peptides by a gluconoyl group prevents the substrates from aminopeptidase degradation and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665c33bb82b45b6450bc11107030f42
https://pubmed.ncbi.nlm.nih.gov/1831333

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