Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Marzena Pazgier"'
Autor:
Mehdi Benlarbi, Shilei Ding, Étienne Bélanger, Alexandra Tauzin, Raphaël Poujol, Halima Medjahed, Omar El Ferri, Yuxia Bo, Catherine Bourassa, Julie Hussin, Judith Fafard, Marzena Pazgier, Inès Levade, Cameron Abrams, Marceline Côté, Andrés Finzi
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The continued evolution of severe acute respiratory syndrome 2 (SARS-CoV-2) requires persistent monitoring of its subvariants. Omicron subvariants are responsible for the vast majority of SARS-CoV-2 infections worldwide, with XBB and BA.2.86
Externí odkaz:
https://doaj.org/article/df2d55c283fd4b6a8524d3f74e18d6e6
Autor:
Fernanda Fortes de Araujo, Maha Abdeladhim, Clarissa Teixeira, Kelly Hummer, Matthew D. Wilkerson, Roseanne Ressner, Ines Lakhal-Naouar, Michael W. Ellis, Claudio Meneses, Saule Nurmukhambetova, Regis Gomes, W. David Tolbert, George W. Turiansky, Marzena Pazgier, Fabiano Oliveira, Jesus G. Valenzuela, Shaden Kamhawi, Naomi Aronson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCutaneous leishmaniasis is a neglected vector-borne parasitic disease prevalent in 92 countries with approximately one million new infections annually. Interactions between vector saliva and the human host alter the response to infection
Externí odkaz:
https://doaj.org/article/ad6b2c84670842d0b46195dd14c3aa2c
Autor:
Jérémie Prévost, Yaozong Chen, Fei Zhou, William D. Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung N. Nguyen, Suneetha Gottumukkala, Ann J. Hessell, Venigalla B. Rao, Edwin Pozharski, Rick K. Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from interacting with the envelope glycoprotein (Env) and blocks its conformational changes. To do this, temsavir relies on the presence of a r
Externí odkaz:
https://doaj.org/article/5ca0ee97820f4768be0d20e9dea09bbe
Autor:
Haleigh E. Conley, Max M. He, David Easterhoff, Hélène Fradin Kirshner, Sarah L. Cocklin, Jacob Meyer, Taylor Hoxie, Madison Berry, Todd Bradley, William D. Tolbert, Marzena Pazgier, Georgia D. Tomaras, Joern E. Schmitz, Michael Anthony Moody, Kevin Wiehe, Justin Pollara
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Fcγ receptors (FcγRs) are membrane-bound glycoproteins that bind to the fragment crystallizable (Fc) constant regions of IgG antibodies. Interactions between IgG immune complexes and FcγRs can initiate signal transduction that mediates important c
Externí odkaz:
https://doaj.org/article/7ca88bbcf7974541b140d919d5470520
Autor:
William D. Tolbert, Yaozong Chen, Lulu Sun, Mehdi Benlarbi, Shilei Ding, Rohini Manickam, Emily Pangaro, Dung N. Nguyen, Suneetha Gottumukkala, Marceline Côté, Frank J. Gonzalez, Andrés Finzi, Zahra R. Tehrani, Mohammad M. Sajadi, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SARS-CoV-2, the virus behind the COVID-19 pandemic, has changed over time to the extent that the current virus is substantially different from what originally led to the pandemic in 2019–2020. Viral variants have modified the severity and transmiss
Externí odkaz:
https://doaj.org/article/b258916f21c94cc0b4e0c87d505b8f25
Autor:
Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D. Tolbert, Jonathan R. Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières, Romain Gasser, Mehdi Benlarbi, Dani Vézina, Sai Priya Anand, Debashree Chatterjee, Guillaume Goyette, Michael W. Grunst, Ziwei Yang, Yuxia Bo, Fei Zhou, Kathie Béland, Xiaoyun Bai, Allison R. Zeher, Rick K. Huang, Dung N. Nguyen, Rebekah Sherburn, Di Wu, Grzegorz Piszczek, Bastien Paré, Doreen Matthies, Di Xia, Jonathan Richard, Priti Kumar, Walther Mothes, Marceline Côté, Pradeep D. Uchil, Vincent-Philippe Lavallée, Martin A. Smith, Marzena Pazgier, Elie Haddad, Andrés Finzi
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105783- (2023)
Summary: Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against
Externí odkaz:
https://doaj.org/article/4347d7b5ecc4456ca4f762f55082f32d
Autor:
Thomas J. Esparza, Yaozong Chen, Negin P. Martin, Helle Bielefeldt-Ohmann, Richard A. Bowen, William D. Tolbert, Marzena Pazgier, David L. Brody
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
There remains an unmet need for globally deployable, low-cost therapeutics for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Previously, we reported on the isolation and in vitro characterization of a potent singl
Externí odkaz:
https://doaj.org/article/f295154b0f66471084d307fec4aa74ca
Autor:
Xiang Li, Neelakshi Gohain, Si Chen, Yinghua Li, Xiaoyuan Zhao, Bo Li, William D. Tolbert, Wangxiao He, Marzena Pazgier, Honggang Hu, Wuyuan Lu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2655-2669 (2021)
Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo, representing a viable therapeutic strategy for cancer treatment. Using phage display techniques,
Externí odkaz:
https://doaj.org/article/6dba24af950545f9801cc764d55e0f51
Autor:
William D. Tolbert, Neelakshi Gohain, Paul G. Kremer, Andrew P. Hederman, Dung N. Nguyen, Verna Van, Rebekah Sherburn, George K. Lewis, Andrés Finzi, Justin Pollara, Margaret E. Ackerman, Adam W. Barb, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques, Macaca mulatta (Mm) share approxi
Externí odkaz:
https://doaj.org/article/35ba42702de84fb390327cdf58ef34a5
Autor:
Shilei Ding, William D. Tolbert, Huile Zhu, Daniel Lee, Lorie Marchitto, Tyler Higgins, Xuchen Zhao, Dung Nguyen, Rebekah Sherburn, Jonathan Richard, Gabrielle Gendron-Lepage, Halima Medjahed, Mohammadjavad Mohammadi, Cameron Abrams, Marzena Pazgier, Amos B. Smith, Andrés Finzi
Publikováno v:
Viruses, Vol 15, Iss 5, p 1185 (2023)
The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by preventing the exposure of Env vulnerable epitopes. Small-molecule
Externí odkaz:
https://doaj.org/article/52e7e420c9a942b2be25abc6e48e553d