Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Maryssa Canuel"'
Autor:
Maryssa Canuel, Xiaowei Sun, Marie-Claude Asselin, Eustache Paramithiotis, Annik Prat, Nabil G Seidah
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64145 (2013)
Elevated LDL-cholesterol (LDLc) levels are a major risk factor for cardiovascular disease and atherosclerosis. LDLc is cleared from circulation by the LDL receptor (LDLR). Proprotein convertase subtilisin/kexin 9 (PCSK9) enhances the degradation of t
Externí odkaz:
https://doaj.org/article/d405b38dea6240e494a5b85426bdb4d3
Publikováno v:
Hepatology. 57:2514-2524
UNLABELLED The first seven members of the proprotein convertase (PC) family activate protein precursors by cleavage after basic residues. While PC7 has no known specific substrates, it shows redundancy with other PCs. A genome-wide association study
Publikováno v:
Medical Science Educator. 22:244-249
Introduction to dynamic histology, an undergraduate course in McGill University’s department of Anatomy and Cell Biology, introduces students to microscopic anatomy and cellular functions. Maintaining student interest throughout the semester has be
Publikováno v:
Journal of Biological Chemistry. 286:2728-2738
The zymogen activation mechanism and physiological functions of the most ancient and highly conserved basic amino acid-specific proprotein convertase 7 (PC7) are not known. Herein, we characterized the biosynthesis, subcellular localization, and traf
Publikováno v:
Experimental Cell Research. 315:240-247
Most soluble lysosomal hydrolases are sorted in the trans-Golgi network (TGN) and delivered to the lysosomes by the mannose 6-phosphate receptor (M6PR). However, the non-enzymic sphingolipid activator protein (SAP), prosaposin, as well as certain sol
Autor:
Stéphane Carpentier, Stéphanie Durand, Roy A. Gravel, Claudia Zwingmann, Feng Liang, Jacques L. Michaud, Karine Landry, Jibin Zeng, Aurore Caqueret, Thierry Levade, Sergio Marchesini, Alexey V. Pshezhetsky, Maryssa Canuel, Carlos R. Morales, Volkan Seyrantepe
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 2008, 17 (11), pp.1556-68. ⟨10.1093/hmg/ddn043⟩
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (11), pp.1556-68. ⟨10.1093/hmg/ddn043⟩
Human Molecular Genetics, 2008, 17 (11), pp.1556-68. ⟨10.1093/hmg/ddn043⟩
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (11), pp.1556-68. ⟨10.1093/hmg/ddn043⟩
International audience; Mammalian sialidase Neu4, ubiquitously expressed in human tissues, is located in the lysosomal and mitochondrial lumen and has broad substrate specificity against sialylated glycoconjugates. To investigate whether Neu4 is invo
Autor:
Yves Jacob, Johann Guillemot, Steve Poirier, Gaétan Mayer, Ann Chamberland, Rachid Essalmani, Nabil G. Seidah, Maryssa Canuel, Chutikarn Butkinaree, Josée Hamelin, Suzanne Benjannet, Sangram S. Sisodia, Anna Roubtsova, Annik Prat, Jadwiga Marcinkiewicz, Marie-Claude Asselin
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2015, 290 (30), pp.18609-18620. ⟨10.1074/jbc.M115.647180⟩
Journal of Biological Chemistry, 2015, 290 (30), pp.18609-18620. ⟨10.1074/jbc.M115.647180⟩
International audience; Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprotein convertase subtilisin/kexin type 9 (PCSK9) and regulate its activity on the low-density lipoprotein receptor (LDLR). The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dfea10e67e53e089a8ae1b56bc846c
https://hal.science/hal-03890285/document
https://hal.science/hal-03890285/document
Autor:
Maryssa Canuel, Roxane Desjardins, Robert Day, Nabil G. Seidah, Yascara Grisel Luna Saavedra, Josée Hamelin, Janice Mayne, Kévin Ly, Sophie Routhier, Claude Lazure
Publikováno v:
The Journal of biological chemistry. 289(25)
Annexin A2 (AnxA2) was reported to be an extracellular endogenous inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) activity on cell-surface LDL receptor degradation. In this study, we investigated the effect of silencing the express
Publikováno v:
Histology and histopathology. 24(4)
The delivery of soluble lysosomal proteins to the lysosomes is dependent primarily on the mannose 6-phosphate receptor (MPR). The MPR has been demonstrated to attain the early endosomes via a process that requires the interaction of its cytosolic dom
Publikováno v:
Biochemical and biophysical research communications. 373(2)
Delivery of soluble lysosomal proteins to the lysosomes is dependent primarily on the mannose 6-phosphate receptor (M6PR). However, in I-cell disease (ICD), in which the M6PR pathway is non-functional, some soluble lysosomal proteins continue to traf