Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Marysia Placzek"'
Publikováno v:
Engineered Regeneration, Vol 5, Iss 1, Pp 11-20 (2024)
Tanycytes are stem/progenitor cells that reside in the hypothalamus of the adult vertebrate brain. Tanycytes can be cultured as free-floating neurospheres in vitro but tend to spontaneously differentiate over time. Here we asked whether morphological
Externí odkaz:
https://doaj.org/article/0804a89eb9974436b0a9cafc007430eb
Autor:
Sofia Sedas Perez, Caitlin McQueen, Holly Stainton, Joseph Pickering, Kavitha Chinnaiya, Patricia Saiz-Lopez, Marysia Placzek, Maria A. Ros, Matthew Towers
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Complex signalling between the apical ectodermal ridge (AER - a thickening of the distal epithelium) and the mesoderm controls limb patterning along the proximo-distal axis (humerus to digits). However, the essential in vivo requirement for
Externí odkaz:
https://doaj.org/article/e210d06c502c48f095a84e784793b84f
Autor:
Kavitha Chinnaiya, Marysia Placzek
Publikováno v:
Bio-Protocol, Vol 13, Iss 23 (2023)
The hypothalamus is an evolutionarily ancient part of the vertebrate ventral forebrain that integrates the dialogue between environment, peripheral body, and brain to centrally govern an array of physiologies and behaviours. Characterizing the mechan
Externí odkaz:
https://doaj.org/article/3de15d025cde4481b74f286149aadb2b
Autor:
Helen Eachus, Lara Oberski, Jack Paveley, Irina Bacila, John-Paul Ashton, Umberto Esposito, Fayaz Seifuddin, Mehdi Pirooznia, Eran Elhaik, Marysia Placzek, Nils P. Krone, Vincent T. Cunliffe
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/aa67d866b66e45b491817fdc22250015
Autor:
Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers, Seth Blackshaw, Marysia Placzek
Publikováno v:
eLife, Vol 12 (2023)
The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its fundamental role, the cells and signalling pathways that specify this unique region of the central nervous system in embryogenesis are poorly characterised. Here
Externí odkaz:
https://doaj.org/article/e0d60551b44541ac9d345002d2655bed
Autor:
Sarah J. Brown, Ibrahim Boussaad, Javier Jarazo, Julia C. Fitzgerald, Paul Antony, Marcus Keatinge, Janna Blechman, Jens C. Schwamborn, Rejko Krüger, Marysia Placzek, Oliver Bandmann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Recent evidence suggests neurogenesis is on-going throughout life but the relevance of these findings for neurodegenerative disorders such as Parkinson’s disease (PD) is poorly understood. Biallelic PINK1 mutations cause early onset, Mende
Externí odkaz:
https://doaj.org/article/f403a11711ed4072a52f7d7dcbd0861e
Autor:
Alex Moore, Kavitha Chinnaiya, Dong Won Kim, Sarah Brown, Iain Stewart, Sarah Robins, Georgina K. C. Dowsett, Charlotte Muir, Marco Travaglio, Jo E. Lewis, Fran Ebling, Seth Blackshaw, Andrew Furley, Marysia Placzek
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expressed in adult
Externí odkaz:
https://doaj.org/article/0e9d8e72a36a4c9a9569ef25f2a81562
Autor:
Christine M Tait, Kavitha Chinnaiya, Elizabeth Manning, Mariyam Murtaza, John-Paul Ashton, Nicholas Furley, Chris J Hill, C Henrique Alves, Jan Wijnholds, Kai S Erdmann, Andrew Furley, Penny Rashbass, Raman M Das, Kate G Storey, Marysia Placzek
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000470 (2020)
In the spinal cord, the central canal forms through a poorly understood process termed dorsal collapse that involves attrition and remodelling of pseudostratified ventricular layer (VL) cells. Here, we use mouse and chick models to show that dorsal v
Externí odkaz:
https://doaj.org/article/f8b3e06e128a4e3d929b8ac00ab8d735
Autor:
Thomas JR Frith, Ilaria Granata, Matthew Wind, Erin Stout, Oliver Thompson, Katrin Neumann, Dylan Stavish, Paul R Heath, Daniel Ortmann, James OS Hackland, Konstantinos Anastassiadis, Mina Gouti, James Briscoe, Valerie Wilson, Stuart L Johnson, Marysia Placzek, Mario R Guarracino, Peter W Andrews, Anestis Tsakiridis
Publikováno v:
eLife, Vol 7 (2018)
The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell types in an axial position-dependent manner. The production of NC cells from human pluripotent stem cells (hPSCs) is a valuable approach to study human NC b
Externí odkaz:
https://doaj.org/article/637c69b4425440b4993a8b7a27e2654f
Autor:
Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers, Seth Blackshaw, Marysia Placzek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39171f2f60f562f153f0a2d2ea20148
https://doi.org/10.7554/elife.83133.sa2
https://doi.org/10.7554/elife.83133.sa2
