Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25

Autor: Mélanie Etheve-Quelquejeu, Maria Chiara Dasso Lang, Maryse Jaouen, Emmanuelle Braud, Christiane Garbay, Marie-Odile Galcera, Gildas Bertho, Marie-Agnès Sari, Maria A. Miteva, Manal Sarkis

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 85:593-601

CDC25 phosphatases play a crucial role in cell cycle regulation. They have been found to be over-expressed in various human tumours and to be valuable targets for cancer treatment. Here, we report the first model of binding of the most potent CDC25 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a15b157b703142bc321572fa1062ef
https://doi.org/10.1002/prot.25236

Molecular characterization of a novel hepcidin (HepcD) fromCamelus dromedarius. Synthetic peptide forms exhibit antibacterial activity

Autor: Mohamed Boumaiza, Mohamed Nejib Marzouki, Aymen Ezzine, Marie-Agnès Sari, Maryse Jaouen

Publikováno v: Journal of Peptide Science. 20:680-688

Hepcidin is a cysteine-rich peptide widely characterized in immunological processes and antimicrobial activity in several vertebrate species. Obviously, this hormone plays a central role in the regulation of systemic iron homeostasis. However, its ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45815b21cdcd5d2416f2e6aa6b832463
https://doi.org/10.1002/psc.2644

Recombinant overexpression of camel hepcidin cDNA in Pichia pastoris: purification and characterization of the polyHis-tagged peptide HepcD-His

Autor: Mohamed Boumaiza, Haifa Chahed, Aymen Ezzine, Maryse Jaouen, Alessandra Gianoncelli, Giovanna Longhi, Fernando Carmona, Paolo Arosio, Marie-Agnès Sari, Mohamed Nejib Marzouki

Publikováno v: Journal of molecular recognition : JMR. 30(1)

Hepcidin, a liver-expressed antimicrobial peptide, has been demonstrated to act as an iron regulatory hormone as well as to exert a wide spectrum of antimicrobial activity. The aim of this work was the expression, as secreted peptide, purification, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05aaff80b1048bb6fa961abf9505dedc
https://pubmed.ncbi.nlm.nih.gov/29898257

Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1

Autor: Jean-Christophe Deschemin, Mohamed Nejib Marzouki, Aymen Ezzine, Noureddine Ben Khalaf, Sophie Vaulont, Maryse Jaouen, Marie Agnès Sari, Mohamed Boumaiza

Publikováno v: Protein Expression and Purification
Protein Expression and Purification, Elsevier, 2015, 115, pp.11-18. ⟨10.1016/j.pep.2015.04.016⟩
Protein Expression and Purification, 2015, 115, pp.11-18. ⟨10.1016/j.pep.2015.04.016⟩
Protein Expression and Purification, Elsevier, 2015, 115, pp.11-18. 〈10.1016/j.pep.2015.04.016〉

International audience; Hepcidin, a 25-amino-acid and highly disulfide bonded antimicrobial peptide, is the central regulator of iron homeostasis. This hormone is expressed in response to iron and inflammation and interacts with ferroportinl (FPN1),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d186469380cd44912338cdbb54a684
https://hal-riip.archives-ouvertes.fr/pasteur-01375021

Molecular characterization of a novel hepcidin (HepcD) from Camelus dromedarius. Synthetic peptide forms exhibit antibacterial activity

Autor: Mohamed, Boumaiza, Aymen, Ezzine, Maryse, Jaouen, Marie-Agnes, Sari, Mohamed Nejib, Marzouki

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 20(9)

Hepcidin is a cysteine-rich peptide widely characterized in immunological processes and antimicrobial activity in several vertebrate species. Obviously, this hormone plays a central role in the regulation of systemic iron homeostasis. However, its ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::000919401e2f81767901969eba706741
https://pubmed.ncbi.nlm.nih.gov/24895313