Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Maryon Hardie"'
Autor:
R. Morrison, Edgar Braendle, Carla Heise, Felix Garzon, Priska Butzberger-Zimmerli, Judith A. Fox, Debashis Sarker, Dalal Jadayel, T.R. Jeffrey Evans, R. Molife, Johann S. de Bono, Sharianne Louie, C. Marriott, Natasha Aziz, Ian Judson, Maryon Hardie, Glenn C. Michelson
Publikováno v:
Clinical Cancer Research. 14:2075-2081
Purpose: To determine the maximum tolerated dose (MTD) dose-limiting toxicity, and pharmacokinetic and pharmacodynamic profile of TKI258 (formerly CHIR-258). Experimental Design: A phase I dose escalating trial in patients with advanced solid tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6887928bac5968eb4cea1962f1c2fe9f
https://doi.org/10.1158/1078-0432.ccr-07-1466
https://doi.org/10.1158/1078-0432.ccr-07-1466
Publikováno v:
Nature Clinical Practice Oncology. 1:88-96
Untangling the complex pathways underlying the major cancer phenotypes remains a significant challenge, but deregulated expression of a single multi-component enzyme, telomerase, is implicated as a causative factor for immortalization in the vast maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2593aaec5ac2edbf9c957f141a6a5b2b
https://doi.org/10.1038/ncponc0044
https://doi.org/10.1038/ncponc0044