Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marynette Rihanek"'
Autor:
Zachary C. Stensland, Brianne M. Coleman, Marynette Rihanek, Ryan M. Baxter, Peter A. Gottlieb, Elena W.Y. Hsieh, Virginia D. Sarapura, Kimber M. Simmons, John C. Cambier, Mia J. Smith
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103626- (2022)
Summary: Autoimmune thyroid disease (AITD) is caused by aberrant activation of the immune system allowing autoreactive B and T cells to target the thyroid gland leading to disease. Although AITD is more frequently diagnosed in adults, children are al
Externí odkaz:
https://doaj.org/article/30cb121fcd7e4390ab3193f5172a949c
Autor:
Zachary C. Stensland, Christopher A. Magera, Hali Broncucia, Brittany D. Gomez, Nasha M. Rios-Guzman, Kristen L. Wells, Catherine A. Nicholas, Marynette Rihanek, Maya J. Hunter, Kevin P. Toole, Peter A. Gottlieb, Mia J. Smith
Publikováno v:
Journal of Experimental Medicine. 220
Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db6dce1c3d3ce1b7eefa7a639af6ff3
https://doi.org/10.1084/jem.20221604
https://doi.org/10.1084/jem.20221604
Autor:
Kathryn Haskins, Anita Hohenstein, Peter A. Gottlieb, Marynette Rihanek, Maki Nakayama, Aaron W. Michels, Rocky L. Baker, Thomas Delong
Publikováno v:
Diabetes
We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of organ donors with type 1 diabetes (T1D). Here, we investigate whether HIP-reactive T cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe0124f4295eef991419b0233dedc6
http://europepmc.org/articles/PMC6702640
http://europepmc.org/articles/PMC6702640
Autor:
Virginia D. Sarapura, Mia J. Smith, John C. Cambier, Marynette Rihanek, Peter A. Gottlieb, Brianne M. Coleman
Publikováno v:
Journal of Autoimmunity. 89:82-89
Autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), is the most common autoimmune disorder in the United States, affecting over 20 million people. At the time of diagnosis, both HD and GD are characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f4442092eed4956f338b4d568fe92e
https://doi.org/10.1016/j.jaut.2017.12.001
https://doi.org/10.1016/j.jaut.2017.12.001
Autor:
Peter A. Gottlieb, Clayton E. Mathews, Mia J. Smith, Mark A. Atkinson, Clive Wasserfall, Marynette Rihanek, John C. Cambier
Publikováno v:
Diabetes
Although B cells reactive with islet autoantigens are silenced by tolerance mechanisms in healthy individuals, they can become activated and contribute to the development of type 1 diabetes. We previously demonstrated that high-affinity insulin-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899a5f1d33a9bc63516c0c5ff9284d01
https://doi.org/10.2337/db17-0937
https://doi.org/10.2337/db17-0937
Autor:
Marynette Rihanek, Aimon K. Alkanani, Peter A. Gottlieb, Dan M. Waid, David H. Wagner, Gisela M. Vaitaitis
Publikováno v:
J Clin Endocrinol Metab
Context The incidence of type 1 diabetes (T1D) is increasing worldwide. The quest to understand T1D etiology and how to predict diabetes is ongoing; and, in many ways, those goals intertwine. Although genetic components associate with T1D, not all in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e21ba9d486a768eee8833fd3f4a6e9a
https://europepmc.org/articles/PMC6685715/
https://europepmc.org/articles/PMC6685715/
Autor:
Mia J Smith, Marynette Rihanek, Zachary Stensland, Virginia Sarapura, Peter Gottlieb, John C Cambier
Publikováno v:
The Journal of Immunology. 204:218.14-218.14
Background Development of autoimmunity requires the activation of autoantigen-reactive T and B cells that are normally silenced by immune tolerance mechanisms. Many potentially dangerous autoreactive B cells are silenced by anergy, wherein cells pers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ccd68241a821e200e15ad8f2de3d914
https://doi.org/10.4049/jimmunol.204.supp.218.14
https://doi.org/10.4049/jimmunol.204.supp.218.14
Autor:
Andrew Getahun, B Rhodes Ford, Peter A. Gottlieb, John C. Cambier, Marynette Rihanek, Brianne M. Coleman, Virginia D. Sarapura, Mia J. Smith
Publikováno v:
JCI insight. 4(3)
It has been reported that 2.5%–30% of human peripheral CD27(–) B cells are autoreactive and anergic based on unresponsiveness to antigen receptor (BCR) stimulation and autoreactivity of cloned and expressed BCR. The molecular mechanisms that main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad24b0f0b42d21c126cf80b7a11196fa
https://pubmed.ncbi.nlm.nih.gov/30728334
https://pubmed.ncbi.nlm.nih.gov/30728334
Autor:
Eddie A, James, Joana R F, Abreu, John W, McGinty, Jared M, Odegard, Yvonne E, Fillié, Claire N, Hocter, Slobodan, Culina, Kristin, Ladell, David A, Price, Aimon, Alkanani, Marynette, Rihanek, Lisa, Fitzgerald-Miller, Ania, Skowera, Cate, Speake, Peter, Gottlieb, Howard W, Davidson, F Susan, Wong, Bart, Roep, Roberto, Mallone
Publikováno v:
Diabetologia. 61(3)
Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance, few options exist for monitoring antigen-specific T cells. Previous reports described a combinatorial approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17cc2c815c8cecbb460f585597e01cff
https://pubmed.ncbi.nlm.nih.gov/29196783
https://pubmed.ncbi.nlm.nih.gov/29196783
Autor:
Thomas A. Packard, John C. Cambier, Shannon K. O’Neill, Peter A. Gottlieb, Mia J. Smith, Rochelle M. Hinman, Marynette Rihanek
B cells reactive with a specific antigen usually occur at a frequency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6422ec0876ae6c869011ea4860f252bf
https://europepmc.org/articles/PMC5409333/
https://europepmc.org/articles/PMC5409333/