PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Autor: Christopher R. S. Banerji, Maryna Panamarova, Husam Hebaishi, Robert B. White, Frédéric Relaix, Simone Severini, Peter S. Zammit

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxid

Externí odkaz: https://doaj.org/article/e4c41a2342de44989834fb0cef7eaaf9

Biocompatible magnetic conjugated polymer nanoparticles for optical and lifetime imaging applications in the first biological window

Autor: Struan Bourke, Federico Donà, Yurema Teijeiro Gonzalez, Basma Qazi Chaudhry, Maryna Panamarova, Eirinn Mackay, Peter S. Zammit, Lea Ann Dailey, Ulrike S. Eggert, Klaus Suhling, Mark A. Green

Publikováno v: Bourke, S, Dona, F, Teijeiro Gonzalez, Y, Qazi Chaudhry, B, Panamarova, M, Mackay, E, Zammit, P S, Dailey, L A, Eggert, U S, Suhling, K & Green, M A 2022, ' Biocompatible magnetic conjugated polymer nanoparticles for optical and lifetime imaging applications in the first biological window ', ACS Applied Polymer Materials, vol. 4, no. 11, pp. 8193–8202 . https://doi.org/10.1021/acsapm.2c01153

Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation of the bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)fluorenylene}-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd4747e3d55fa3f8025787fea6e1587
https://kclpure.kcl.ac.uk/ws/files/188038183/Biocompatible_Magnetic_Conjugated_Polymer_BOURKE_Publishedonline12October2022_GOLD_VoR_CC_BY_.pdf

Cellular imaging using emission-tuneable conjugated polymer nanoparticles

Autor: Mark Green, Maryna Panamarova, Yurema Teijeiro Gonzalez, Ulrike S. Eggert, Struan Bourke, Lea Ann Dailey, Klaus Suhling, Peter S. Zammit, Federico Donà

Publikováno v: Bourke, S, Teijeiro Gonzalez, Y, Dona, F, Panamarova, M, Suhling, K, Eggert, U, Dailey, L A, Zammit, P & Green, M A 2019, ' Cellular imaging using emission-tuneable conjugated polymer nanoparticles ', RSC Advances, vol. 9, no. 65, pp. 37971–37976 . https://doi.org/10.1039/C9RA07983A

New materials that exhibit tuneable optical properties, notable emission across the visible spectrum, are of immense interest to biologists as they present a broad palette of colours from a single imaging agent that can be utilised in biological dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f843bd38dac2d9d11899840170b8078
https://pubmed.ncbi.nlm.nih.gov/35541819

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis

Autor: Louise A. Moyle, Christopher R. S. Banerji, Silvère M. van der Maarel, Paul Knopp, Maryna Panamarova, Bianca den Hamer, Peter S. Zammit, Yvonne D. Krom

Publikováno v: Journal of Cell Science, 129(20), 3816-3831
Journal of Cell Science
Knopp, P, Krom, Y D, Banerji, C R S, Panamarova, M, Moyle, L A, den Hamer, B, van der Maarel, S M & Zammit, P S 2016, ' DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis ', Journal of Cell Science, vol. 129, no. 20, pp. 3816-3831 . https://doi.org/10.1242/jcs.180372

Skeletal muscle wasting in facioscapulohumeral muscular dystrophy (FSHD) results in substantial morbidity. On a disease-permissive chromosome 4qA haplotype, genomic and/or epigenetic changes at the D4Z4 macrosatellite repeat allows transcription of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7527185b6db1c69f8b1bbaa2e249197
http://hdl.handle.net/1887/113797

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

Autor: Aliaksandra Radzisheuskaya, Vincent Pasque, Maryna Panamarova, Richard P. Halley-Stott, Magdalena Zernicka-Goetz, Astrid Gillich, José C. R. Silva, M. Azim Surani

Publikováno v: Journal of Cell Science

How cell fate becomes restricted during somatic cell differentiation is a long-lasting question in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during embryonic development are expected to stabilize the differentiated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc5739c0e4590f92bd6e78f5914cfd3
https://doi.org/10.1242/jcs.113019