Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation

Autor: Maryline Abrial, Sandeep Basu, Mengmeng Huang, Vincent Butty, Asya Schwertner, Spencer Jeffrey, Daniel Jordan, Caroline E. Burns, C. Geoffrey Burns

Publikováno v: Disease Models & Mechanisms, Vol 15, Iss 3 (2022)

Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages o

Externí odkaz: https://doaj.org/article/560982aa1f5a477990b4927c8afac99d

Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and Desflurane

Autor: Pauline Sueur, Rania Harisseh, Michel Ovize, Pascal Chiari, Abdallah Gharib, Maryline Abrial, Camille Villedieu, Jean-Luc Fellahi

Publikováno v: Journal of Cardiovascular Pharmacology
12. International Symposium for Mechanisms of Vasodilatation
12. International Symposium for Mechanisms of Vasodilatation, Nov 2016, Rochester, United States. ⟨10.1097/FJC.0000000000000479⟩
12. International Symposium for Mechanisms of Vasodilatation, Nov 2016, Rochester United States. ⟨10.1097/FJC.0000000000000479⟩

Background: Volatile anesthetics are known to limit myocardial ischemia-reperfusion injuries. Mitochondria were shown to be major contributors to cardioprotection. Cyclophilin D (CypD) is one of the main regulators of mitochondria-induced cell death.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19181329993416b1fe62e188b202a619
https://doi.org/10.1097/fjc.0000000000000479

A modified calcium retention capacity assay clarifies the roles of extra- and intracellular calcium pools in mitochondrial permeability transition pore opening

Autor: Rania, Harisseh, Maryline, Abrial, Pascal, Chiari, Ribal, Al-Mawla, Camille, Villedieu, Nolwenn, Tessier, Gabriel, Bidaux, Michel, Ovize, Abdallah, Gharib

Publikováno v: J Biol Chem

Calcium homeostasis is essential for cell survival and is precisely controlled by several cellular actors such as the sarco/endoplasmic reticulum and mitochondria. Upon stress induction, Ca(2+) released from sarco/endoplasmic reticulum stores and fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fff662f62981e67296930f0c1cd5454
https://pubmed.ncbi.nlm.nih.gov/31434742

Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition

Autor: Abdallah Gharib, Annie Varennes, Thomas Bochaton, Vincent Jahandiez, Laurent Argaud, Martin Cour, Michel Ovize, Joseph Loufouat, Maryline Abrial

Publikováno v: Basic Research in Cardiology
Basic Research in Cardiology, Springer Verlag, 2017, 112 (4), ⟨10.1007/s00395-017-0624-3⟩

The opening of the mitochondrial permeability transition pore (PTP), which is regulated by the matrix protein cyclophilin D (CypD), plays a key role in the pathophysiology of post-cardiac arrest (CA) syndrome. We hypothesized that therapeutic hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cead9d272dcd3e4c4801b354f9abffe2
https://doi.org/10.1007/s00395-017-0624-3

Cardiac fibroblasts protect cardiomyocytes against lethal ischemia–reperfusion injury

Autor: Lionel Augeul, Geoffrey Teixeira, René Ferrera, Régine Cartier, Denis Angoulvant, Claire Crola Da Silva, Bruno Pillot, Fabrice Ivanes, Michel Ovize, Maryline Abrial

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2014, 68, pp.56-65. ⟨10.1016/j.yjmcc.2014.01.005⟩

International audience; Roles of cardiac fibroblasts (CFs) in the regulation of myocardial structure and function have been emphasized in the last decade. Their implications in pathophysiological aspects of chronic heart diseases such as myocardial r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01910af0af565610b6be11ed5d377e4d
https://doi.org/10.1016/j.yjmcc.2014.01.005