Výsledky vyhledávání - "Marycarmen Arévalo-Martínez"

Akademický článek

Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

Autor: Marycarmen Arévalo Martínez, Olivia Ritsvall, Joakim Armstrong Bastrup, Selvi Celik, Gabriel Jakobsson, Fatima Daoud, Christopher Winqvist, Anders Aspberg, Catarina Rippe, Lars Maegdefessel, Alexandru Schiopu, Thomas A. Jepps, Johan Holmberg, Karl Swärd, Sebastian Albinsson

Publikováno v: JCI Insight, Vol 8, Iss 17 (2023)

Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs). Here, we identified r

Externí odkaz: https://doaj.org/article/67045162d4754a58bf9c3dedcded4eaf

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Elastin-like recombinamer-based devices releasing Kv1.3 blockers for the prevention of intimal hyperplasia: An in vitro and in vivo study

Autor: F. Javier Arias, Mercedes Santos, M. Teresa Pérez-García, Pilar Cidad, Sofía Serrano, Marycarmen Arévalo-Martínez, Sara Moreno-Estar, José R. López-López

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Coronary artery disease (CAD) is the most common cardiovascular disorder. Vascular surgery strategies for coronary revascularization (either percutaneous or open) show a high rate of failure because of restenosis of the vessel, due to phenotypic swit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb3baae241743045d2a7d1330f6fa85
https://doi.org/10.1016/j.actbio.2020.07.053

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miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Autor: José R. López-López, Pilar Cidad, Mirella Fernández, Sebastian Albinsson, Sara Moreno-Estar, M. Teresa Pérez-García, Irene Cózar-Castellano, Marycarmen Arévalo-Martínez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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UVaDOC. Repositorio Documental de la Universidad de Valladolid
Molecular Metabolism, Vol 53, Iss, Pp 101306-(2021)
Molecular Metabolism

Producción Científica
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbcc347fd83fc9d342ee5c3f4b295be
http://hdl.handle.net/10261/260813

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Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation

Autor: Miguel Angel de la Fuente, Enrique Calvo, Esperanza Alonso, José R. López-López, Pilar Cidad, Marycarmen Arévalo-Martínez, M. Teresa Pérez-García

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d494a1663e25328a29f1175ccb7ada
https://pubmed.ncbi.nlm.nih.gov/33230847

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Use of Kv1.3 channel blockers for the prevention of restenosis in human vessels: Mechanisms and outcomes in diabetic patients

Autor: Marycarmen Arévalo Martínez

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
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Vascular smooth muscle cells (VSMCs) can undergo phenotypic modulation (PM) to a dedifferentiated state, which contributes to angiogenesis and vessel repair. PM is triggered by vascular surgeries such as those directed to unclog obstructed vessels. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1bb947080459b3c4e7803703fd90d8
https://doi.org/10.35376/10324/43490

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Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ Culture

Autor: Pilar Cidad, Mirella Fernández, Sara Moreno-Estar, M. Teresa Pérez-García, Miguel Angel de la Fuente, José R. López-López, Nadia García-Mateo, Julia Serna, Marycarmen Arévalo-Martínez, María Simarro, Karl Swärd

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Arterioscler Thromb Vasc Biol
Digital.CSIC. Repositorio Institucional del CSIC

[Objective]: We have previously described that changes in the expression of Kv channels associate to phenotypic modulation (PM), so that Kv1.3/Kv1.5 ratio is a landmark of vascular smooth muscle cells phenotype. Moreover, we demonstrated that the Kv1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc9ff8ee5dda5e54c4f9a96b24c77fd
https://doi.org/10.1161/atvbaha.119.313492

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Akademický článek

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Autor: Marycarmen Arevalo-Martinez, Pilar Cidad, Sara Moreno-Estar, Mirella Fernández, Sebastian Albinsson, Irene Cózar-Castellano, José R. López-López, M. Teresa Pérez-Garcia

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101306- (2021)

Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patien

Externí odkaz: https://doaj.org/article/e00a9e75cdf44eabb6c98499dacf5b54

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