Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

Autor: Marycarmen Arévalo Martínez, Olivia Ritsvall, Joakim Armstrong Bastrup, Selvi Celik, Gabriel Jakobsson, Fatima Daoud, Christopher Winqvist, Anders Aspberg, Catarina Rippe, Lars Maegdefessel, Alexandru Schiopu, Thomas A. Jepps, Johan Holmberg, Karl Swärd, Sebastian Albinsson

Publikováno v: JCI Insight, Vol 8, Iss 17 (2023)

Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs). Here, we identified r

Externí odkaz: https://doaj.org/article/67045162d4754a58bf9c3dedcded4eaf

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Autor: José R. López-López, Pilar Cidad, Mirella Fernández, Sebastian Albinsson, Sara Moreno-Estar, M. Teresa Pérez-García, Irene Cózar-Castellano, Marycarmen Arévalo-Martínez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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UVaDOC. Repositorio Documental de la Universidad de Valladolid
Molecular Metabolism, Vol 53, Iss, Pp 101306-(2021)
Molecular Metabolism

Producción Científica
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbcc347fd83fc9d342ee5c3f4b295be
http://hdl.handle.net/10261/260813

Use of Kv1.3 channel blockers for the prevention of restenosis in human vessels: Mechanisms and outcomes in diabetic patients

Autor: Marycarmen Arévalo Martínez

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname

Vascular smooth muscle cells (VSMCs) can undergo phenotypic modulation (PM) to a dedifferentiated state, which contributes to angiogenesis and vessel repair. PM is triggered by vascular surgeries such as those directed to unclog obstructed vessels. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1bb947080459b3c4e7803703fd90d8
https://doi.org/10.35376/10324/43490