Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marybeth Pysz"'
Autor:
Philip Vitorino, Alexander J. Bankovich, Monette Aujay, Zhaomei Zhang, Angeline T. Dang, Christina Lee, Dorothy French, Theodore Sullivan, Kumiko Isse, Monica You, Christine Gu, Marybeth Pysz, Hetal Sarvaiya, Xi Zhao, Alexander Schammel, Julia Gavrilyuk, Wolf R. Wiedemeyer
Supplementary Figure from ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e04dfbdd6edb05fe4f748df6a64c4e
https://doi.org/10.1158/1535-7163.22522480.v1
https://doi.org/10.1158/1535-7163.22522480.v1
Autor:
Philip Vitorino, Alexander J. Bankovich, Monette Aujay, Zhaomei Zhang, Angeline T. Dang, Christina Lee, Dorothy French, Theodore Sullivan, Kumiko Isse, Monica You, Christine Gu, Marybeth Pysz, Hetal Sarvaiya, Xi Zhao, Alexander Schammel, Julia Gavrilyuk, Wolf R. Wiedemeyer
In the past year, four antibody–drug conjugates (ADC) were approved, nearly doubling the marketed ADCs in oncology. Among other attributes, successful ADCs optimize targeting antibody, conjugation chemistry, and payload mechanism of action. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747b7f4105aad333d4f4a606f7dcdc81
https://doi.org/10.1158/1535-7163.c.6543391.v1
https://doi.org/10.1158/1535-7163.c.6543391.v1
Autor:
Scott J. Dylla, Hans-Peter Gerber, Puja Sapra, Hadi Falahatpisheh, Frank Barletta, Robert Stull, Johannes Hampl, Orit Foord, Kathryn Loving, Timothy Nichols, Justin Lucas, Judy Lucas, Erik Upeslacis, Wenyan Zhong, Marybeth Pysz, Jeffrey Bernstein, Paul Escarpe, Elana Ernstoff, Virginia Pulito, Kiran Khandke, Sarah Fong, Monette Aujay, Marianne Santaguida, Wade Anderson, Jorge Aguilar, Albert Park, Alexander Bankovich, Marc Damelin
Purpose: Triple-negative breast cancer (TNBC) and ovarian cancer each comprise heterogeneous tumors, for which current therapies have little clinical benefit. Novel therapies that target and eradicate tumor-initiating cells (TIC) are needed to signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ad6d27feffc9b7ae90f84aa16d05e
https://doi.org/10.1158/1078-0432.c.6523641.v1
https://doi.org/10.1158/1078-0432.c.6523641.v1
Autor:
Scott J. Dylla, Hans-Peter Gerber, Puja Sapra, Hadi Falahatpisheh, Frank Barletta, Robert Stull, Johannes Hampl, Orit Foord, Kathryn Loving, Timothy Nichols, Justin Lucas, Judy Lucas, Erik Upeslacis, Wenyan Zhong, Marybeth Pysz, Jeffrey Bernstein, Paul Escarpe, Elana Ernstoff, Virginia Pulito, Kiran Khandke, Sarah Fong, Monette Aujay, Marianne Santaguida, Wade Anderson, Jorge Aguilar, Albert Park, Alexander Bankovich, Marc Damelin
Supplementary Figures 1-4. Supplementary Figure 1. Analysis of EFNA4 copy number in breast and hepatocellular carcinoma. Supplementary Figure 2. Characterization of PF-06647263 conjugates. Supplementary Figure 3. Biomarkers of PF-06647263 activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d14fed96e16e890f6829719918e5df
https://doi.org/10.1158/1078-0432.22457655.v1
https://doi.org/10.1158/1078-0432.22457655.v1
Autor:
Wolf R. Wiedemeyer, Julia Gavrilyuk, Alexander Schammel, Xi Zhao, Hetal Sarvaiya, Marybeth Pysz, Christine Gu, Monica You, Kumiko Isse, Theodore Sullivan, Dorothy French, Christina Lee, Angeline T. Dang, Zhaomei Zhang, Monette Aujay, Alexander J. Bankovich, Philip Vitorino
Publikováno v:
Molecular cancer therapeutics. 21(6)
In the past year, four antibody–drug conjugates (ADC) were approved, nearly doubling the marketed ADCs in oncology. Among other attributes, successful ADCs optimize targeting antibody, conjugation chemistry, and payload mechanism of action. Here, w
Autor:
Subhrajit Rout, Kyriacos C. Nicolaou, Baiwei Lin, Marybeth Pysz, Emmanuel N. Pitsinos, Hanan Fernando, Christina E. Lee, Anukriti Dhar, Joseph Sandoval, Yong Lu, Stephan Rigol, Monette Aujay, Dane Holte, Nicole Taylor, Hetal Sarvaiya, Amanda M. Valdiosera, Dipendu Das, Alexander Schammel, Christine Gu, Julia Gavrilyuk, Holger Karsunky, Jose Trinidad, Nicole Barbour
Publikováno v:
Proc Natl Acad Sci U S A
Significance A number of antibody–drug conjugates (ADCs) with varying linkers carrying an uncialamycin analogue as payload were synthesized and tested for their cytotoxicity in vitro and in PDX mouse models. Importantly, a number of these enediyne-
Autor:
Scott J. Dylla, Zhaomei Zhang, Aaron Kempema, Sheila Bheddah, Laura Saunders, Shravanthi Madhavan, Christine Saechao, Sandro Vivona, Alina He, Marybeth Pysz, Monette Aujay, Alex Bankovich, Kimberly Walter, Erik Huntzicker, Xi Zhao, David Liu, Kristyn Hayashi, Julia Gavrilyuk, Vikram Natwarsinhji Sisodiya, Holger Karsunky, Dorothy French, Wolf R. Wiedemeyer, Johannes Hampl
Publikováno v:
Clinical Cancer Research. 25:NT-113
Disclosures: All authors are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the publication. Ovarian cancer d