Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marybeth HOWARD"'
Autor:
Marybeth Howard, Karen E. Iles, Jérémie Roux, Dale A. Dickinson, Arnaud Goolaerts, Sarah C. Christiaans, Jean-Francois Pittet, Byron Miyazawa, Michael A. Matthay, Naseem Anjum
Publikováno v:
Shock (Augusta, Ga.), vol 39, iss 2
Acute lung injury (ALI) is a clinical syndrome characterized by hypoxia, which is caused by the breakdown of the alveolar capillary barrier. Interleukin 1β (IL-1β), a cytokine released within the airspace in ALI, downregulates the α subunit of the
Autor:
Mitchell J. Cohen, José A. Fernández, Mathieu Lafargue, Michel Carles, Nastasha Bir, Arnaud Goolaerts, Karen E. Iles, Jean-Francois Pittet, Marybeth Howard, John H. Griffin, Jérémie Roux
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:632-641
Inhibition of the small GTPase RhoA attenuates the development of pulmonary edema and restores positive alveolar fluid clearance in a murine model of Pseudomonas aeruginosa pneumonia. Activated protein C (aPC) blocks the development of an unfavorably
Autor:
Marybeth Howard, John Swindle, Joe Hedgpeth, Yuanlin Song, Jérémie Roux, David Weston, Mathieu Lafargue, Michel Carles, Jean-Francois Pittet, Arnaud Goolaerts, Fanny Burel-Vandenbos
Publikováno v:
Anesthesiology. 113:1134-1143
Background Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe pneumonia in critically ill patients. We have reported previously that P. aeruginosa exotoxins S and T mediate in vitro the increase in protein permeability across l
Autor:
Marybeth Howard, Brian B. Chesebro, Walter E. Finkbeiner, Jérémie Roux, Kevan M. Shokat, Michael T. Ganter, Jean-Francois Pittet, Hidefumi Koh, Michel Carles, Arnaud Goolaerts, Michael A. Matthay, Benjamin T. Houseman, Agnes C. Paquet
Publikováno v:
Journal of Biological Chemistry. 285:4278-4290
Exogenous or endogenous beta(2)-adrenergic receptor agonists enhance alveolar epithelial fluid transport via a cAMP-dependent mechanism that protects the lungs from alveolar flooding in acute lung injury. However, impaired alveolar fluid clearance is
Autor:
Michael T. Ganter, Yoram Weiss, Marybeth Howard, Clifford S. Deutschman, Eric Kipnis, George Su, Susan V. Lynch, Sarah C. Christiaans, Byron Myazawa, Jean-Francois Pittet, Jérémie Roux, Jeanine P. Wiener-Kronish
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 40:108-118
Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe pneumonia associated with airspace flooding with protein-rich edema in critically ill patients. The type III secretion system is a major virulence factor and contributes to dis
Autor:
Yves Berthiaume, Jérémie Roux, George Su, Jean-Francois Pittet, Cecilia M. Canessa, André Dagenais, Xiaohui Fang, Hisaaki Kawakatsu, Marybeth Howard, Michael A. Matthay, James A. Frank, Dean Sheppard
Publikováno v:
Journal of Biological Chemistry. 278:43939-43950
Acute lung injury (ALI) is characterized by the flooding of the alveolar airspaces with protein-rich edema fluid and diffuse alveolar damage. We have previously reported that transforming growth factor-beta1 (TGF-beta1) is a critical mediator of ALI
Publikováno v:
Biochemical Journal. 354:561-572
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase (PKA)-activated chloride channel that is localized to the plasma membrane and endosomal compartment. Endosomal targeting of CFTR is attributed to the Ty
Publikováno v:
American Journal of Physiology-Cell Physiology. 273:C2080-C2089
We asked whether inclusion of the FLAG epitope in the fourth extracellular loop of the cystic fibrosis transmembrane conductance regulator (M2–901/CFTR), which permits detection of cell surface expression, affected CFTR’s biophysical properties o
Autor:
Jean-Francois Pittet, Yuanlin Song, Jérémie Roux, Mehrdad Arjomandi, Mathieu Lafargue, Karen E. Iles, Michel Carles, Arnaud Goolaerts, Byron Miyazawa, Dale A. Parks, Marybeth Howard
Publikováno v:
Thorax. 66(9)
Elevated plasma and bronchoalveolar lavage fluid plasminogen activator inhibitor 1 (PAI-1) levels are associated with adverse clinical outcome in patients with pneumonia caused by Pseudomonas aeruginosa. However, whether PAI-1 plays a pathogenic role
Autor:
Amanda J Howard, Byron Miyazawa, Marybeth Howard, Jae-Woo Lee, Michael A. Matthay, Jérémie Roux, Jean-Francois Pittet, Hyon Lee, Brandi Gartland, Michel Carles
Publikováno v:
Thorax. 65(4)
Background and aim Alveolar fluid clearance is impaired by inducible nitric oxide synthase (iNOS)/nitric oxide (NO)-dependent mechanisms in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The activation of the stress protein respo