Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marybeth Camboni"'
Autor:
Victoria M. Velazquez, Aaron S. Meadows, Ricardo J. Pineda, Marybeth Camboni, Douglas M. McCarty, Haiyan Fu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 159-168 (2017)
Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome pre-existing Abs. Given the complexity of Ab production, overcoming pre-existing Abs will require bro
Externí odkaz:
https://doaj.org/article/4cdfca763436483c990da691c72dee3a
Autor:
Marybeth Camboni, Chiou-Miin Wang, Carlos Miranda, Jung Hae Yoon, Rui Xu, Deborah Zygmunt, Brian K. Kaspar, Paul T. Martin
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 31-43 (2014)
Recent clinical and pre-clinical studies suggest that both active and passive immunization strategies targeting Aβ amyloid may have clinical benefit in Alzheimer's disease. Here, we demonstrate that vaccination of APPswePSEN1dE9 mice with SDPM1, an
Externí odkaz:
https://doaj.org/article/ea58be5f665549689ab0cfe161b984cc
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 409-422 (2010)
Vaccination has become an important therapeutic approach to the treatment of Alzheimer's disease (AD), however, immunization with Aβ amyloid can have unwanted, potentially lethal, side effects. Here we demonstrate an alternative peptide-mimotope vac
Externí odkaz:
https://doaj.org/article/e011341541e548d38efeaaa05a0a3207
Autor:
Paul T Martin, Bethannie Golden, Jonathan Okerblom, Marybeth Camboni, Kumaran Chandrasekharan, Rui Xu, Ajit Varki, Kevin M Flanigan, Joe N Kornegay
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88226 (2014)
The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice. Here, we describe the expression of these two glycans in sk
Externí odkaz:
https://doaj.org/article/a786211db0af4d3e8d907d3f3b518646
Autor:
Ricardo J. Pineda, Aaron S. Meadows, Douglas M. McCarty, Marybeth Camboni, Victoria Velazquez, Haiyan Fu
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 159-168 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 159-168 (2017)
Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome pre-existing Abs. Given the complexity of Ab production, overcoming pre-existing Abs will require bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757c1e2bddc2c3550cd7d723367c7aa1
http://europepmc.org/articles/PMC5363314
http://europepmc.org/articles/PMC5363314
Autor:
Douglas M. McCarty, Christopher Shilling, Brad Bolon, William G. Bremer, Christopher M. Walker, Kimberly Zaraspe, Aaron S. Meadows, Chrystal L. Montgomery, Haiyan Fu, Kevin M. Flanigan, F. Jason Duncan, Kathryn Waligura, Marybeth Camboni, Bartholomew J. Naughton, Kim L. McBride
Publikováno v:
Human Gene Therapy Clinical Development. 26:228-242
No treatment is currently available for mucopolysaccharidosis (MPS) IIIB, a neuropathic lysosomal storage disease due to defect in α-N-acetylglucosaminidase (NAGLU). In preparation for a clinical trial, we performed an IND-enabling GLP-toxicology st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1cdc642a089e4aa7179bc701b4ba04
https://doi.org/10.1089/humc.2015.132
https://doi.org/10.1089/humc.2015.132
Autor:
Rui Xu, Marybeth Camboni, Chiou-Miin Wang, Paul T. Martin, Brian K. Kaspar, Carlos Henrique Miranda, Deborah A. Zygmunt, Jung Hae Yoon
Publikováno v:
Neurobiology of Disease, Vol 62, Iss, Pp 31-43 (2014)
Recent clinical and pre-clinical studies suggest that both active and passive immunization strategies targeting Aβ amyloid may have clinical benefit in Alzheimer's disease. Here, we demonstrate that vaccination of APPswePSEN1dE9 mice with SDPM1, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434497354abaded58f8fb47331b29ee7
http://www.sciencedirect.com/science/article/pii/S0969996113002374
http://www.sciencedirect.com/science/article/pii/S0969996113002374
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 409-422 (2010)
Vaccination has become an important therapeutic approach to the treatment of Alzheimer's disease (AD), however, immunization with Abeta amyloid can have unwanted, potentially lethal, side effects. Here we demonstrate an alternative peptide-mimotope v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c63173241a943a4bd2b28d888b1bd1
http://www.sciencedirect.com/science/article/pii/S0969996110001646
http://www.sciencedirect.com/science/article/pii/S0969996110001646
Autor:
Rui Xu, Jerry R. Mendell, Kim Shontz, Louis G. Chicoine, Marybeth Camboni, K. Reed Clark, Paul T. Martin, Zarife Sahenk, Chrystal L. Montgomery, Elaine Oglesbay, Louise R. Rodino-Klapac, Paul M.L. Janssen
Publikováno v:
American Journal of Physiology-Cell Physiology. 296:C476-C488
The cytotoxic T cell (CT) GalNAc transferase, or Galgt2, is a UDP-GalNAc:β1,4- N-acetylgalactosaminyltransferase that is localized to the neuromuscular synapse in adult skeletal muscle, where it creates the synaptic CT carbohydrate antigen {GalNAcβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72dd499daf013a993010261aa5b070f
https://doi.org/10.1152/ajpcell.00456.2008
https://doi.org/10.1152/ajpcell.00456.2008
Autor:
Chrystal Mongomery, F. Jason Duncan, Brad Bolon, Christopher M. Walker, Marybeth Camboni, Kevin M. Flanigan, William G. Bremer, Haiyan Fu, Kathryn Waligura, Aaron S. Meadows, Douglas M. McCarty, Kim L. McBride
Publikováno v:
Molecular Therapy. 23
No treatment is currently available for mucopolysaccharidosis (MPS) IIIB, a neuropathic lysosomal storage disease due to autosomal recessive defect in α-N-acetylglucosaminidase (NAGLU). In preparation for a clinical trial, we performed an IND-enabli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f972065760b6c375a68559b88a3cb7e0