Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia

Autor: Karen Blindauer, Lauren Seeberger, Brian Wulbrecht, Joan Young, Victoria Hunt, Judith Dobson, Lisa Byder, Clifford W. Shults, Deborah Fontaine, William C. Nichols, P. Michael Conneally, Carolyn Peterson, Julie H. Carter, Hubert H. Fernandez, Margaret C. Lannon, William C. Koller, Joanne Wojcieszek, Lawrence Elmer, Jayaraman Rao, Mark Stacy, Jo Belden, Bala V. Manyam, Julie So, Theresa Shirley, Stephen G. Reich, Stephanie Thomas, John M. Bertoni, Peggy Gray, Marguerite Wieler, Anette Nieves, Rachel Saunders Pullman, Mayank Pathak, Kenneth Marek, Debra Berry, Holly Delgado, Christopher F. O'Brien, Anthony E. Lang, Karen Marder, Ali H. Rajput, Eric Siemers, Cheryl Halter, Michel Panisset, Galit Kleimer-Fisman, Kelly E. Lyons, Robyn Schacherer, Richard Camicioli, Tatiana Foroud, Alex Rajput, Carson Reider, Kathy Davis, Robert A. Hauser, Theresa A. Zesiewicz, Deborah Judd, Susan Mendick, Maryan De Angelis, Sandra Roque, Alice Rudolph, Becky Dunlop, An Tran, Maureen Cook, Christine Hunter, Daniel D. Truong, Stewart A. Factor, Michael J. Aminoff, David Oakes, Sharon Evans, Paul J. Tuite, Jean Hall, David Grimes, W.R. Wayne Martin, Magali Fernandez, Joanna Hamman, Francis O. Walker, Pam Andrews, Karyn Boyar, Juliette Harris, Tilak Mendis, Nathan Pankratz, Mariann DiMinno, Robert L. Rodnitzky, Rajesh Pahwa, Peter A. LeWitt, Jeannine Petit, William J. Weiner, Un Jung Kang, Joseph Jankovic, Ronald F. Pfeiffer, Aileen Shinaman, Jean P. Hubble, Mark Forrest Gordon, Danna Jennings, Joseph H. Friedman, Carmen Serrano Ramos, Roger Kurlan, Kelli Williamson, Brenda Pfeiffer, Frederick J. Marshall

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 21(1)

The epsilon4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dad4eef80e5b861c95a811d7fa272c1
https://pubmed.ncbi.nlm.nih.gov/16116614