Výsledky vyhledávání - "Maryam Zamiri"

2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing

Autor: Zabrina L. Brumme, Mark A. Brockman, Peter Cheung, Benoit Chabot, David S. Grierson, Alan Cochrane, Maryam Zamiri

Publikováno v: ACS Med Chem Lett

[Image: see text] The observation that stilbene 3 (5350150) blocks HIV replication through its impact on HIV mRNA processing prompted a program to develop non-cytotoxic analogues that maintain its mechanism of action. This initially involved replacem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a5d9aa2a55dda934e453039796d201
https://europepmc.org/articles/PMC8591739/

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The Reaction of N-Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides

Autor: Maryam Zamiri, Ana Koperniku, David S. Grierson

Publikováno v: Synthesis. 51:1779-1790

The S-benzyl thioester and methyl ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situ from the N-trimethylsilyl d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62e6e6a303ba0086eb5e8bdda3167ebe
https://doi.org/10.1055/s-0037-1611435

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A Trimethylsilylamine-Acyl Fluoride Amide Bond Forming Protocol for Weakly Nucleophilic Amines that is Amenable to the Parallel Synthesis of Di(hetero)arylamides

Autor: David S. Grierson, Maryam Zamiri

Publikováno v: Synthesis. 49:571-578

The reaction of a 2-pyridinone-based acid fluoride with the N–TMS derivatives of different weakly nucleophilic heteroaryl/arylamines in acetonitrile containing catalytic fluoride ion provides a clean, efficient and simple means to access a diverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8042afb4aab297b18a186ada6e269743
https://doi.org/10.1055/s-0036-1588603

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A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing

Autor: Stoyan K. Karagiosov, Safwat M. Rabea, David S. Grierson, P. Richard Harrigan, Steven McArthur, Mitra Matloobi, Maryam Zamiri, Benoit Chabot, Laura E. Bandy, Peter K. Cheung, David Horhant

Publikováno v: Journal of Medicinal Chemistry. 59:1869-1879

A 256-compound library was evaluated in an anti-HIV screen to identify structural "mimics" of the fused tetracyclic indole compound 1 (IDC16) that conserve its anti-HIV activity without associated cytotoxicity. Four diheteroarylamide-type compounds,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0228199419d5a412ac288b5f65b8755f
https://doi.org/10.1021/acs.jmedchem.5b01357

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Akademický článek

The Reaction of N -Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides.

Autor: Koperniku, Ana, Zamiri, Maryam, Grierson, David S.

Publikováno v: Synthesis; 2019, Vol. 51 Issue 8, p1779-1790, 12p

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Akademický článek

A Trimethylsilylamine-Acyl Fluoride Amide Bond Forming Protocol for Weakly Nucleophilic Amines that is Amenable to the Parallel Synthesis of Di(hetero)arylamides.

Autor: Zamiri, Maryam, Grierson, David S.

Publikováno v: Synthesis; 2017, Vol. 49 Issue 3, p571-578, 8p, 3 Diagrams, 1 Chart

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