Reversal of Right Ventricular Hypertrophy and Dysfunction by Prostacyclin in a Rat Model of Severe Pulmonary Arterial Hypertension

Autor: Rebecca R. Vanderpool, Anastasia Gorelova, Yiran Ma, Mohammad Alhamaydeh, Jeffrey Baust, Sruti Shiva, Stevan P. Tofovic, Jian Hu, Seyed Mehdi Nouraie, Mark T. Gladwin, Maryam Sharifi-Sanjani, Imad Al Ghouleh

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5426 (2022)

Prostacyclin analogs are among the most effective and widely used therapies for pulmonary arterial hypertension (PAH). However, it is unknown whether they also confer protection through right ventricle (RV) myocardio-specific mechanisms. Moreover, th

Externí odkaz: https://doaj.org/article/ba858a8e30fd46d98b5344b4e5303627

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

Autor: Elisia D. Tichy, David K. Sidibe, Matthew T. Tierney, Michael J. Stec, Maryam Sharifi-Sanjani, Harish Hosalkar, Scott Mubarak, F. Brad Johnson, Alessandra Sacco, Foteini Mourkioti

Publikováno v: Stem Cell Reports, Vol 9, Iss 4, Pp 1328-1341 (2017)

Muscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, m

Externí odkaz: https://doaj.org/article/53d32f4122614c7e89b36de0894eaa3d

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

Autor: Anastasia Gorelova, Mariah Berman, Maryam Sharifi-Sanjani, Andres Pulgarin Rocha, Anas Alsuraimi, Patricia Riva, Vinny Negi, Thomas Bertero, Dmitry Goncharov, Tatiana Kudryashova, Atinuke Dosunmu-Ogunbi, Arun Rajaratnam, Lloyd Harvey, Mehdi Nouraie, Jeffrey Baust, Timothy Bachman, Andrea Sebastiani, John Sembrat, Sara O. Vargas, Aaron B. Waxman, Rajan Saggar, Rahul Kumar, Brian Graham, Adam C. Straub, Elena A. Goncharova, Ana Mora, Stephen Y. Chan, Imad Al Ghouleh

ObjectivePulmonary hypertension (PH) is a cardiopulmonary disease manifesting in increased pulmonary arterial pressure and right ventricular dysfunction. PH pathogenesis involves extensive pulmonary vascular remodeling precipitated, at least in part,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53447361f5aac8c3c0c74d31db8f28cc
https://doi.org/10.1101/2022.05.31.494181

Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation

Autor: Christine S. Moravec, Maryam Sharifi-Sanjani, T. Avolio, Mohammad AlHamaydeh, Mark A. Ross, Baojun Chang, Mariah Berman, Claudette M. St. Croix, Seyed Mehdi Nouraie, Imad Al Ghouleh, Jeffrey J. Baust, Dmitry A. Goncharov, Ahasanul Kobir, Charles F. McTiernan, Elena A. Goncharova

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6164, p 6164 (2021)
International journal of molecular sciences, vol 22, iss 11
International Journal of Molecular Sciences
Volume 22
Issue 11

Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the downstream effector

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c8cb82c3939c52dcf7889489887393
https://www.mdpi.com/1422-0067/22/11/6164

Role and Contribution of A2 Adenosine Receptors in the Regulation of Coronary Flow

Autor: Maryam Sharifi Sanjani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0df0ec466c276a9887cb5d0236aa9bbc
https://doi.org/10.33915/etd.4788