Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Maryam Khoshouei"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J. Belousoff, Hari Venugopal, Tin T. Truong, Alisa Glukhova, Andrew N. Keller, Karen J. Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A. Reynolds, Peishen Zhao, Patrick M. Sexton, Denise Wootten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by
Externí odkaz:
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs comple
Externí odkaz:
https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Single particle cryo-EM is commonly used for the structure determination of large complexes. Here, the authors present the 3.2 Å resolution cryo-EM structure of human haemoglobin, which has a molecular weight of 64 kDa.
Externí odkaz:
https://doaj.org/article/901eebcd1f124312b1e5309b7dcbdef7
Autor:
Maryam Khoshouei, Mazdak Radjainia, Amy J. Phillips, Juliet A. Gerrard, Alok K. Mitra, Jürgen M. Plitzko, Wolfgang Baumeister, Radostin Danev
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Although the resolution achievable with cryo-EM can now rival crystallography, its application to small protein assemblies remains challenging. Here the authors demonstrate the use of the Volta phase plate for single particle analysis and its potenti
Externí odkaz:
https://doaj.org/article/3d06cce2b2344e8f80bcc7ebd49bfda0
Autor:
Lachlan Clydesdale, Hari Venugopal, Peishen Zhao, Patrick M. Sexton, Alisa Glukhova, Arthur Christopoulos, Christopher A. Reynolds, Yi Lynn Liang, Xin Zhang, Tin T. Truong, Andrew N. Keller, Maryam Khoshouei, Matthew J. Belousoff, Karen J. Gregory, Giuseppe Deganutti, Radostin Danev, Denise Wootten, Katie Leach
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications
Nature Communications
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5aa9dcac923a091ce55a4b69969de5
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
Madeleine M. Fletcher, Xin Zhang, Debbie L. Hay, Matthew J. Belousoff, Patrick M. Sexton, Giuseppe Deganutti, Arthur Christopoulos, Yi Lynn Liang, Denise Wootten, Maryam Khoshouei, Radostin Danev, Laurence J. Miller, Christopher A. Reynolds, Sebastian G.B. Furness, Cassandra Koole
Publikováno v:
ACS Pharmacology & Translational Science. 3:263-284
Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) receptors are critically important for metabolism, vascular tone, and inflammatory response. AM receptors are also required for normal lymphatic and blood vascular development and angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d626fd22ff4a442c70386d8f9b536b
https://doi.org/10.1021/acsptsci.9b00080
https://doi.org/10.1021/acsptsci.9b00080
Autor:
Arthur Christopoulos, Sebastian G.B. Furness, Yi Lynn Liang, Giuseppe Deganutti, Matthew J. Belousoff, Maoqing Dong, Christopher A. Reynolds, Alisa Glukhova, Sarah J. Piper, Radostin Danev, Patrick M. Sexton, Maryam Khoshouei, Denise Wootten, Kaleeckal G. Harikumar, Laurence J. Miller
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Molecular understanding of SecR binding and activation is important for its therapeutic exploitation. We co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095ff17c121c4e6cf026f4b65f53375
https://doi.org/10.1038/s41467-020-17791-4
https://doi.org/10.1038/s41467-020-17791-4
Autor:
Dimitar Angelov, Seyit Kale, Sunil Nahata, Stefan Dimitrov, Lorrie Ramos, Ali Hamiche, Maryam Khoshouei, Jan Bednar, Carlo Petosa, Radostin Danev, Ramachandran Boopathi
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (10), pp.5735-5748. ⟨10.1093/nar/gkaa246⟩
Nucleic Acids Research (London)
Nucleic Acids Research, 2020, 48 (10), pp.5735-5748. ⟨10.1093/nar/gkaa246⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (10), pp.5735-5748. ⟨10.1093/nar/gkaa246⟩
Nucleic Acids Research (London)
Nucleic Acids Research, 2020, 48 (10), pp.5735-5748. ⟨10.1093/nar/gkaa246⟩
The histone H3 variant CENP-A marks centromeres epigenetically and is essential for mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle (NCP) reconstituted with a human α-satellite DNA derivative revealed both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7286b67a827a8e6dd716a3bd7d0f250
https://hal.archives-ouvertes.fr/hal-03102278/document
https://hal.archives-ouvertes.fr/hal-03102278/document
