Simultaneous inhibition of aryl hydrocarbon receptor (AhR) and Src abolishes androgen receptor signaling.

Autor: Maryam Ghotbaddini, Keyana Cisse, Alexis Carey, Joann B Powell

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0179844 (2017)

Altered c-Src activity has been strongly implicated in the development, growth, progression, and metastasis of human cancers including prostate cancer. Src is known to regulate several biological functions of tumor cells, including proliferation. The

Externí odkaz: https://doaj.org/article/c1b2af0f6b76413797504c8fcda5dff0

10th Royan Institute's International Summer School on 'Molecular Biomedicine: From Diagnostics to Therapeutics'

Autor: Arezoo Rasti, Saeed Mohebbi, Piter J. Bosma, Parisa Torabi, Jafar Kiani, Mehdi Shamsara, Maryam Ghotbaddini, Sadegh Babashah, Farnoush Faridbod, Samira Gholami, Hamid Sadeghi-Abandansari, Vahid Khoddami, Morteza Hosseini, Sara Amjadian, Faezeh Shekari, Mohammad Kazemi-Ashtiani, Sharif Moradi

Publikováno v: BioEssays, 42(6):2000042. John Wiley and Sons Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0fe59666eaa4d460d9a3a58019fab8
http://www.scopus.com/inward/record.url?scp=85083492335&partnerID=8YFLogxK

The AhR Ligand, TCDD, Regulates Androgen Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells

Autor: Maryam Ghotbaddini, Joann B. Powell

Publikováno v: International Journal of Environmental Research and Public Health, Vol 12, Iss 7, Pp 7506-7518 (2015)
International Journal of Environmental Research and Public Health
Volume 12
Issue 7
Pages 7506-7518

The reported biological effects of TCDD include induction of drug metabolizing enzymes, wasting syndrome and tumor promotion. TCDD elicits most of its effects through binding the aryl hydrocarbon receptor (AhR). TCDD induced degradation of AhR has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5603aea458b6aab04ad466ee8a90511
http://www.mdpi.com/1660-4601/12/7/7506

Abstract 2629: Constitutive AhR signaling enhances androgen receptor signaling and growth in prostate cancer cells

Autor: Maryam Ghotbaddini, Sakura McLaughlin, Kailen Turner, Devyn Pirtle, Joann B. Powell

Publikováno v: Cancer Research. 79:2629-2629

The aryl hydrocarbon receptor (AhR) has been reported to interact with multiple signaling pathways during prostate cancer progression to castration resistant prostate cancer (CRPC) including the androgen receptor. Previously published data from our l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f9f93ed2e1aae20e9ba79609c7d1a10
https://doi.org/10.1158/1538-7445.am2019-2629

The Aryl Hydrocarbon Receptor Is Constitutively Active in Advanced Prostate Cancer Cells

Autor: Maryam Ghotbaddini, Alice Walker, Oliver Richmond, Cidney J. Allen, Shokouh Taghipour Zahir, Joann B. Powell

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95058 (2014)

Background Distant prostate cancers are commonly hormone refractory and exhibit increased growth no longer inhibited by androgen deprivation therapy. Understanding all molecular mechanisms contributing to uncontrolled growth is important to obtain ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df80b314fce7a5b634055d2f3f9421
http://europepmc.org/articles/PMC3995675