OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases

Autor: Kate J. Heesom, Punyawee Dulyayangkul, Naphat Satapoomin, Matthew B. Avison, Maryam Alzayn

Cefalexin is a widely used 1st generation cephalosporin, and resistance in Escherichia coli is caused by Extended-Spectrum (e.g. CTX-M) and AmpC β-lactamase production and therefore frequently coincides with 3rd generation cephalosporin resistance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27b61f859db0345801c87a83c8a83d95
https://doi.org/10.1101/2021.05.16.444350

Characterization of AmpC-hyperproducing Escherichia coli from humans and dairy farms collected in parallel in the same geographical region

Autor: David C Barrett, Oliver Mounsey, Virginia C. Gould, Maryam Alzayn, Matthew B. Avison, Katy Turner, Kate J. Heesom, Jacqueline Findlay, Hannah Schubert, Kristen K. Reyher

Publikováno v: Alzayn, M, Findlay, J, Schubert, H, Mounsey, O, Gould, V C, Heesom, K J, Turner, K M, Barrett, D C, Reyher, K K & Avison, M B 2020, ' Characterization of AmpC-hyperproducing Escherichia coli from humans and dairy farms collected in parallel in the same geographical region ', Journal of Antimicrobial Chemotherapy, vol. 75, no. 9, dkaa207, pp. 2471-2479 . https://doi.org/10.1093/jac/dkaa207

ObjectivesTo characterize putative AmpC-hyperproducing third-generation cephalosporin-resistant E. coli from dairy farms and their phylogenetic relationships; to identify risk factors for their presence; and to assess evidence for their zoonotic tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e9eddef0a676f5664e789e55f76479
https://pubmed.ncbi.nlm.nih.gov/32542329