Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Autor: Stein Hallan, Maryam Afkarian, Leila R. Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H. de Boer

Publikováno v: EBioMedicine, Vol 26, Iss C, Pp 68-77 (2017)

Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCM

Externí odkaz: https://doaj.org/article/a4d0f131e2714adf87397a4be51fc2bb

Spatial proteomics of human diabetic kidney disease, from health to class III

Autor: Ayano Kondo, Monee McGrady, Dhiraj Nallapothula, Hira Ali, Alexandro E. Trevino, Amy Lam, Ryan Preska, H. Blaize D’Angio, Zhenqin Wu, Lauren Lopez, Harshanna Kaur Badhesha, Chenoa Rochel Vargas, Achyuta Ramesh, Nasim Wiegley, Seung Seok Han, Marc Dall’Era, Kuang-Yu Jen, Aaron T. Mayer, Maryam Afkarian

Aims/HypothesisDiabetic kidney disease (DKD) remains a significant cause of morbidity and mortality in people with diabetes. Though animal models have taught us much about the molecular mechanisms of DKD, translating these findings to human disease r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7cbc886ec46791369929a21d929de6b
https://doi.org/10.1101/2023.04.12.534028

Diabetic kidney disease in children and adolescents: an update

Autor: Lauren N. Lopez, Weijie Wang, Lindsey Loomba, Maryam Afkarian, Lavjay Butani

Publikováno v: Pediatric nephrology (Berlin, Germany), vol 37, iss 11

Diabetic kidney disease (DKD), previously encountered predominantly in adult patients, is rapidly gaining center stage as a childhood morbidity and one that pediatric nephrologists are likely to encounter with increasing frequency. This is in large p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fee9456c420e021c513e8a45b79b63
https://escholarship.org/uc/item/6vt482g8

Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Autor: J. S. Haw, Michael Mauer, Janet B. McGill, Jill P. Crandall, Bruce A. Perkins, Ruth S. Weinstock, Katherine R. Tuttle, Afshin Parsa, Tom Elliott, Peter Rossing, Amy B. Karger, Amisha Wallia, Cathie Spino, Mark E. Molitch, I. H. de Boer, Maryam Afkarian, David Z.I. Cherney, Sylvia E. Rosas, Irl B. Hirsch, Sarit Polsky, Allison B. Goldfine, Andrzej T. Galecki, Guillermo E. Umpierrez, Ronald J. Sigal, Marlon Pragnell, Ildiko Lingvay, M. L. Caramori, Rodica Pop-Busui, Ronnie Aronson, William N. Robiner, Chun Yi Wu, David M. Maahs, Peter A. Senior, Alessandro Doria

Publikováno v: N Engl J Med

BACKGROUND: Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1 diabetes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6ef2b59ae2513d4a7415a3b5af846c
https://doi.org/10.1056/nejmoa1916624

Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study

Autor: Katherine A Sauder, Jeanette M Stafford, Elizabeth J Mayer-Davis, Elizabeth T Jensen, Sharon Saydah, Amy Mottl, Lawrence M Dolan, Richard F Hamman, Jean M Lawrence, Catherine Pihoker, Santica Marcovina, Ralph B D'Agostino, Dana Dabelea, Maryam Afkarian, James Amrhein, Natalie Beauregard, Ronny Bell, Anna Bellatorre, Clifford A. Bloch, Deborah Bowlby, Ralph D'Agostino, Stephen Daniels, Jasmin Divers, Lawrence M. Dolan, Vinod P. Gaur, Maureen T. Goldstein, Carla Greenbaum, Richard F. Hamman, Jessica Harting, Leora Henkin, Irl Hirsch, Kim Holmquist, Giuseppina Imperatore, Scott Isom, Malaka Jackson, Michael G. Kahn, Sue Kearns, Grace Kim, Georgeanna J. Klingensmith, Mary Klingsheim, Lisa Knight, Corinna Koebnick, Jean M. Lawrence, Xia Li, Angela D. Liese, Barbara Linder, Lenna L. Liu, Beth Loots, Kathy Love-Osborne, David Maahs, Santica M. Marcovina, Elizabeth J. Mayer-Davis, Anwar Merchant, Lina Merjaneh, Timothy Morgan, Debika Nandi-Munshi, John Neff, Bryce Nelson, Michael Pascual, David J. Pettitt, June Pierce, Jeffrey Powell, Beth Reboussin, Marian J. Rewers, Kristi Reynolds, Sharon H. Saydah, Jeanette Stafford, Debra A. Standiford, Greg Strylewicz, Craig Taplin, Lisa Testaverde, Joan Thomas, Paul Wadwa, Lynne E. Wagenknecht, Greta Wilkening, Carrie Williams, Davene Wright, Joyce Yi-Frazier

Publikováno v: The Lancet Child & Adolescent Health. 3:35-43

Summary Background One in three adolescents and young adults with type 1 diabetes have at least one early diabetes-related complication or comorbidity. We aimed to examine the prevalence and pattern of co-occurring complications in this population, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de00152f61bca414d6b55fb65c10f80
https://doi.org/10.1016/s2352-4642(18)30309-2