Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maryam Abdussamad"'
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101939- (2023)
Summary: CD8 T and NK cells mediate killing by delivery of perforin and granzyme B (GZB) stored in lysosome-like granules. We present a flow-cytometry-based protocol combined with a redirected killing assay to evaluate granule exocytosis and the cyto
Externí odkaz:
https://doaj.org/article/0c2eab04221c472c987215773bcb0981
Autor:
Maryam AbdusSamad, Tong Li, Joseph Timpone, Jai Kumar, Princy Kumar, Ryan C Hunt, Marta Catalfamo
Publikováno v:
The Journal of Immunology. 208:161.16-161.16
SARS-CoV-2 is one of the leading causes of mortality worldwide with rising death toll over 5.4 million. The severe presentation of the disease is associated with systemic inflammation, activation of the coagulation cascade and immunological dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22a59383587b918fcd532d093d42ca0
https://doi.org/10.4049/jimmunol.208.supp.161.16
https://doi.org/10.4049/jimmunol.208.supp.161.16
Autor:
You-Shin Chen, Sivanesan Dakshanamurthy, Anirudh Gaur, Dean S. Rosenthal, Emanuel F. Petricoin, John L. Zapas, Michael B. Atkins, Hong-Bin Fang, Stephen W. Byers, Hengbo Zhou, Valerie S. Calvert, Cynthia M. Simbulan-Rosenthal, Maryam AbdusSamad
Publikováno v:
Oncotarget
// Cynthia M. Simbulan-Rosenthal 1,* , Sivanesan Dakshanamurthy 1,2,* , Anirudh Gaur 1 , You-Shin Chen 1 , Hong-Bin Fang 3 , Maryam Abdussamad 4 , Hengbo Zhou 4 , John Zapas 4 , Valerie Calvert 5 , Emanuel F. Petricoin 5 , Michael B. Atkins 2 , Steph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc26ccc0cb58dcae5cef492822be9a4
http://europepmc.org/articles/PMC5355037
http://europepmc.org/articles/PMC5355037
Autor:
Sahar Vakili, Cynthia M. Simbulan-Rosenthal, Anirudh Gaur, Leala Aljehane, Qing Qin, Maryam AbdusSamad, Kumari Karna, Dean S. Rosenthal, Ryan Dougherty, Li-Wei Kuo, Havens Clark, Edward C. McCarron, Hengbo Zhou
Publikováno v:
Journal of Oncology, Vol 2019 (2019)
Journal of Oncology
Journal of Oncology
FDA-approved kinase inhibitors are now used for melanoma, including combinations of the MEK inhibitor trametinib, and BRAF inhibitor dabrafenib for BRAFV600 mutations. NRAS-mutated cell lines are also sensitive to MEK inhibitionin vitro, and NRAS-mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba3cc85454464d78f1d72a85bdec42
https://doaj.org/article/4bc1a2ea927b4c6980ad111513c16496
https://doaj.org/article/4bc1a2ea927b4c6980ad111513c16496
Autor:
Jonathan Krakoff, Yunhua L. Muller, Clifton Bogardus, Meghan Mullins, John Tran, William C. Knowler, Maryam Abdussamad, Robert L. Hanson, Leslie J. Baier, Marie S. Thearle
Publikováno v:
Diabetes
Features of melanocortin-4 receptor (MC4R) deficiency have been observed to be more pronounced in childhood. Longitudinal data from a population-based study were used to separate the phenotypic effects of MC4R deficiency during childhood and adulthoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fd6e14b238a754e47799a007188023
https://doi.org/10.2337/db11-0708
https://doi.org/10.2337/db11-0708
Autor:
Matthias Kretzler, William C. Knowler, Tennille Leak-Johnson, Maryam Abdussamad, Yunhua L. Muller, Shujera Bhutta, Paolo Piaggi, E. Jennifer Weil, Robert G. Nelson, Sayuko Kobes, Clifton Bogardus, Leslie J. Baier, Robert L. Hanson, Ke Huang
Publikováno v:
Human molecular genetics. 24(10)
A prior genome-wide association study (GWAS) in Pima Indians identified a variant within PFKFB2 (rs17258746) associated with body mass index (BMI). PFKFB2 encodes 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase isoform 2, which plays a role in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78e2524b55f92a98efacf5ad85fe32a
https://pubmed.ncbi.nlm.nih.gov/25662186
https://pubmed.ncbi.nlm.nih.gov/25662186
Autor:
Robert L. Hanson, Nellie A. McLean, Sayuko Kobes, Paolo Piaggi, Maryam Abdussamad, Robert G. Nelson, William C. Knowler, Leslie J. Baier, Yunhua L. Muller, E. Jennifer Weil, Jeffrey M. Curtis, Anup K. Nair
Publikováno v:
Diabetologia
Aim/hypothesis A recent genome-wide trans-ancestry meta-analysis identified seven new loci associated with type 2 diabetes. We assessed the replication of the seven lead single nucleotide polymorphisms (SNPs) and evaluated these loci for additional s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97d424015408c788b9dd5f63e10a9a5
http://hdl.handle.net/11568/925428
http://hdl.handle.net/11568/925428
Autor:
Leslie J. Baier, Ke Huang, V. Ossowski, Li Bian, Jeff Sutherland, Maryam Abdussamad, Christopher Wiedrich, Robert L. Hanson, Yunhua L. Muller, E. Jennifer Weil, Clifton Bogardus, Darin Mahkee, Tingwei Guo, Sayuko Kobes, Robert G. Nelson, Michael Traurig, Peter H. Bennett, Kim Wiedrich, William C. Knowler
Publikováno v:
Diabetes
Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM in American Indians. Participants were sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d03aefb3543bba6461ff7c5bae8a7a
https://pubmed.ncbi.nlm.nih.gov/24101674
https://pubmed.ncbi.nlm.nih.gov/24101674
Autor:
Maryam AbdusSamad, Cynthia M. Simbulan-Rosenthal, Anirudh Gaur, Dean S. Rosenthal, Edward C. McCarron
Publikováno v:
Cancer Research. 76:2501-2501
Melanoma is an aggressive and lethal form of cancer with increasing incidence worldwide. In recent years, the FDA approved several promising treatments for malignant melanoma. However, treatment often fails due to the survival and regrowth of drug-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14652e9068c953f7b98c8b7677a34a7c
https://doi.org/10.1158/1538-7445.am2016-2501
https://doi.org/10.1158/1538-7445.am2016-2501
Autor:
Hengbo Zhou, Dean S. Rosenthal, Anirudh Gaur, Cynthia M. Simbulan-Rosenthal, Maryam AbdusSamad, Edward C. McCarron, John L. Zapas
Publikováno v:
Cancer Research. 75:4224-4224
Melanoma is an aggressive and lethal form of cancer, responsible for 9,710 deaths in the US every year, as indicated by the Surveillance Epidemiology and End Results (SEER) program. Although early stages are surgically treatable, the advanced or meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948aacf7bc5f2814f250075b515ca022
https://doi.org/10.1158/1538-7445.am2015-4224
https://doi.org/10.1158/1538-7445.am2015-4224