Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Maryam, Shoai"'
Autor:
Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, Ole A. Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J. Farrer, Michael A. Nalls, Andrew B. Singleton, Nigel M. Williams, Yoav Ben-Shlomo, John Hardy, Michele T. M. Hu, Donald G. Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R. Morris
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining
Externí odkaz:
https://doaj.org/article/b1dcf9f75c9e4bc4bc4699609e993749
Autor:
Alejandro Martinez-Carrasco, Raquel Real, Michael Lawton, Hirotaka Iwaki, Manuela M. X. Tan, Lesley Wu, Nigel M. Williams, Camille Carroll, Michele T. M. Hu, Donald G. Grosset, John Hardy, Mina Ryten, Tom Foltynie, Yoav Ben-Shlomo, Maryam Shoai, Huw R. Morris
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The genetic basis of levodopa-induced-dyskinesia (LiD) is poorly understood, and there have been few well-powered genome-wide studies. We performed a genome-wide survival meta-analyses to study the effect of genetic variation on the developm
Externí odkaz:
https://doaj.org/article/cec4d30a7b3a4bf787d978b96c439ea7
Autor:
Regina H. Reynolds, Aaron Z. Wagen, Frida Lona-Durazo, Sonja W. Scholz, Maryam Shoai, John Hardy, Sarah A. Gagliano Taliun, Mina Ryten
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Genetic correlation ( $$r_g$$ r g ) between traits can offer valuable insight into underlying shared biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often manifest comorbid neuropsychiatric symptoms. However
Externí odkaz:
https://doaj.org/article/b0e583f1318d4c5b8e09718abb18ca78
Autor:
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Qihao Guo, Kin Y. Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.
Externí odkaz:
https://doaj.org/article/1179b0a6657942b580123646d3f1699e
Autor:
Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0281440 (2023)
IntroductionBoth late-onset Alzheimer's disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated. Variability in the es
Externí odkaz:
https://doaj.org/article/51b3981e072d44fe9ab7932f0edb784c
Autor:
Atul Kumar, Maryam Shoai, Sebastian Palmqvist, Erik Stomrud, John Hardy, Niklas Mattsson-Carlgren, Oskar Hansson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cognitive decline in early-stage Alzheimer’s disease (AD) may depend on genetic variability. In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence, and educational attainment) to predict longitudinal cognitiv
Externí odkaz:
https://doaj.org/article/eca63dc7f9f04a0a98a3074419d85dc2
Autor:
Regina H. Reynolds, Aaron Z. Wagen, Frida Lona-Durazo, Sonja W. Scholz, Maryam Shoai, John Hardy, Sarah A. Gagliano Taliun, Mina Ryten
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2d9fc6d5119b495b8bffdef40665f386
Autor:
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Nicole C. H. Lai, Yolanda Y. T. Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Kit Cheung, Estella P. S. Tong, Ho Ko, Maryam Shoai, Kin Y. Mok, John Hardy, Vincent C. T. Mok, Timothy C. Y. Kwok, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Dozens of Alzheimer's disease (AD)‐associated loci have been identified in European‐descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population. Methods TaqMan array genot
Externí odkaz:
https://doaj.org/article/79ab601c621849de94302d253f43db99
Autor:
Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton, Matthew C Baker, Hannah L Macpherson, Raquel Real, Alexandra I Soto-Beasley, Kin Mok, Tamas Revesz, Thomas T Warner, Zane Jaunmuktane, Bradley F Boeve, Elizabeth A Christopher, Michael DeTure, Ranjan Duara, Neill R Graff-Radford, Keith A Josephs, David S Knopman, Shunsuke Koga, Melissa E Murray, Kelly E Lyons, Rajesh Pahwa, Joseph E Parisi, Ronald C Petersen, Jennifer Whitwell, Lea T Grinberg, Bruce Miller, Athena Schlereth, William W Seeley, Salvatore Spina, Murray Grossman, David J Irwin, Edward B Lee, EunRan Suh, John Q Trojanowski, Vivianna M Van Deerlin, David A Wolk, Theresa R Connors, Patrick M Dooley, Matthew P Frosch, Derek H Oakley, Iban Aldecoa, Mircea Balasa, Ellen Gelpi, Sergi Borrego-Écija, Rosa Maria de Eugenio Huélamo, Jordi Gascon-Bayarri, Raquel Sánchez-Valle, Pilar Sanz-Cartagena, Gerard Piñol-Ripoll, Laura Molina-Porcel, Eileen H Bigio, Margaret E Flanagan, Tamar Gefen, Emily J Rogalski, Sandra Weintraub, Javier Redding-Ochoa, Koping Chang, Juan C Troncoso, Stefan Prokop, Kathy L Newell, Bernardino Ghetti, Matthew Jones, Anna Richardson, Andrew C Robinson, Federico Roncaroli, Julie Snowden, Kieren Allinson, Oliver Green, James B Rowe, Poonam Singh, Thomas G Beach, Geidy E Serrano, Xena E Flowers, James E Goldman, Allison C Heaps, Sandra P Leskinen, Andrew F Teich, Sandra E Black, Julia L Keith, Mario Masellis, Istvan Bodi, Andrew King, Safa-Al Sarraj, Claire Troakes, Glenda M Halliday, John R Hodges, Jillian J Kril, John B Kwok, Olivier Piguet, Marla Gearing, Thomas Arzberger, Sigrun Roeber, Johannes Attems, Christopher M Morris, Alan J Thomas, Bret M. Evers, Charles L White, Naguib Mechawar, Anne A Sieben, Patrick P Cras, Bart B De Vil, Peter Paul P.P. De Deyn, Charles Duyckaerts, Isabelle Le Ber, Danielle Seihean, Sabrina Turbant-Leclere, Ian R MacKenzie, Catriona McLean, Matthew D Cykowski, John F Ervin, Shih-Hsiu J Wang, Caroline Graff, Inger Nennesmo, Rashed M Nagra, James Riehl, Gabor G Kovacs, Giorgio Giaccone, Benedetta Nacmias, Manuela Neumann, Lee-Cyn Ang, Elizabeth C Finger, Cornelis Blauwendraat, Mike A Nalls, Andrew B Singleton, Dan Vitale, Cristina Cunha, Agostinho Carvalho, Zbigniew K Wszolek, Huw R Morris, Rosa Rademakers, John A Hardy, Dennis W Dickson, Jonathan D Rohrer, Owen A Ross
Publikováno v:
medRxiv
BackgroundPick’s disease (PiD) is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. PiD is pathologically defined by argyrophilic inclusion Pick bodies and ballooned neurons in the frontal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb436da4c7362a38f76655e19fddf0a
https://europepmc.org/articles/PMC10168402/
https://europepmc.org/articles/PMC10168402/
Autor:
Erik Stomrud, John Hardy, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Oskar Hansson, Atul Kumar, Maryam Shoai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Cognitive decline in early-stage Alzheimer’s disease (AD) may depend on genetic variability. In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence, and educational attainment) to predict longitudinal cognitive change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a57b0845386b0c9725b59ca97657f9b
https://doaj.org/article/eca63dc7f9f04a0a98a3074419d85dc2
https://doaj.org/article/eca63dc7f9f04a0a98a3074419d85dc2