Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Maryam, Clausen"'
Autor:
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)
Abstract Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liv
Externí odkaz:
https://doaj.org/article/6ef35220f5cb430495895d01dab6b095
Autor:
Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of
Externí odkaz:
https://doaj.org/article/140262651e644238bf169dc86b4b8869
Autor:
Tomasz Kostrzewski, Sophie Snow, Anya Lindström Battle, Samantha Peel, Zahida Ahmad, Jayati Basak, Manasa Surakala, Aurelie Bornot, Julia Lindgren, Maria Ryaboshapkina, Maryam Clausen, Daniel Lindén, Christian Maass, Lucy May Young, Adam Corrigan, Lorna Ewart, David Hughes
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the m
Externí odkaz:
https://doaj.org/article/2fe033487d4045ff86e6fb36c7f3e8b7
Autor:
Nikki Carter, Maryam Clausen, Rebecca A. Halpin, Colin Blackmore, Kang Cai, Oona Delpuech, Alexander Kohlmann, Otto Magnusson, Ruth March, Daniel O’Neill, Kasthuri Prakash, James Sherwood, Tabetha Sundin, Jason Swift, Azar Tarakameh, Marilou Wijdicks, Daniel Wise, Mark Fidock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca have also prioritised
Externí odkaz:
https://doaj.org/article/cd949d71d09d40a391ffbdef580d8d56
Autor:
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be
Externí odkaz:
https://doaj.org/article/8d05a4aa843b419591409ca746b331db
Autor:
Muhammad Arif, Martina Klevstig, Rui Benfeitas, Stephen Doran, Hasan Turkez, Mathias Uhlén, Maryam Clausen, Johannes Wikström, Damla Etal, Cheng Zhang, Malin Levin, Adil Mardinoglu, Jan Boren
Publikováno v:
eLife, Vol 10 (2021)
Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in
Externí odkaz:
https://doaj.org/article/3773ce265234459eb41aa49c78f1ab73
Autor:
Susan Monkley, Jayendra Kumar Krishnaswamy, Melker Göransson, Maryam Clausen, Johan Meuller, Kristofer Thörn, Ryan Hicks, Stephen Delaney, Louise Stjernborg
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243807 (2020)
Induced pluripotent stem cells (iPSC) offer the possibility to generate diverse disease-relevant cell types, from any genetic background with the use of cellular reprogramming and directed differentiation. This provides a powerful platform for diseas
Externí odkaz:
https://doaj.org/article/8866dc9e7d7c4d558c5325042769e7f8
Autor:
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Publikováno v:
Molecular Metabolism, Vol 10, Iss , Pp 74-86 (2018)
Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pa
Externí odkaz:
https://doaj.org/article/68b32ae0380845d7a7bc838551e3e8a7
Autor:
Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, Anna Falk
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1030-1045 (2018)
Summary: In vivo studies of human brain cellular function face challenging ethical and practical difficulties. Animal models are typically used but display distinct cellular differences. One specific example is astrocytes, recently recognized for con
Externí odkaz:
https://doaj.org/article/744833d558064ed48a43910333ebf5f2
Autor:
Mikael Bjursell, Michelle J. Porritt, Elke Ericson, Amir Taheri-Ghahfarokhi, Maryam Clausen, Lisa Magnusson, Therese Admyre, Roberto Nitsch, Lorenz Mayr, Leif Aasehaug, Frank Seeliger, Marcello Maresca, Mohammad Bohlooly-Y, John Wiseman
Publikováno v:
EBioMedicine, Vol 29, Iss , Pp 104-111 (2018)
α1-antitrypsin (AAT) is a circulating serine protease inhibitor secreted from the liver and important in preventing proteolytic neutrophil elastase associated tissue damage, primarily in lungs. In humans, AAT is encoded by the SERPINA1 (hSERPINA1) g
Externí odkaz:
https://doaj.org/article/5cdfb46980354003a31f9eadc1ae3710