Zobrazeno 1 - 10
of 31
pro vyhledávání: '"MaryPeace McRae"'
Autor:
Michael Ohene-Nyako, Sara R. Nass, Hope T. Richard, Robert Lukande, Melanie R. Nicol, MaryPeace McRae, Pamela E. Knapp, Kurt F. Hauser
Publikováno v:
ASN Neuro, Vol 15 (2023)
Aberrant phosphorylation and subsequent aggregation of the trans-activation response (TAR) element DNA binding protein 43 (TDP-43) is a common feature of multiple neurodegenerative disorders and contributes to disease severity. Here, we investigated
Externí odkaz:
https://doaj.org/article/40944578bd644a5e9ee9fadf91aff448
Publikováno v:
Journal of the International Association of Providers of AIDS Care, Vol 10 (2011)
Background: KP-1461 is a prodrug to KP-1212. KP-1212 is a viral mutagen designed to increase viral error rate. Methods: We describe 2 phase I studies: KP1461-101 (double-blind, placebo-controlled, single, escalating doses, 100 to 1600 mg study in 42
Externí odkaz:
https://doaj.org/article/b76a22c5e2e1494d8ad4f7b5f41ccc78
Publikováno v:
Journal of Neuroimmune Pharmacology
With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS). Recent advances in experimental mod
Autor:
Crystal R, Leibrand, Jason J, Paris, Austin M, Jones, Michael, Ohene-Nyako, Kara M, Rademeyer, Sara R, Nass, Woong-Ki, Kim, Pamela E, Knapp, Kurt F, Hauser, MaryPeace, McRae
Publikováno v:
Neuroscience Letters. 788:136852
Despite advances in the treatment of human immunodeficiency virus (HIV), approximately one-half of people infected with HIV (PWH) experience neurocognitive impairment. Opioid use disorder (OUD) can exacerbate the cognitive and pathological changes se
Autor:
Patricia W. Slattum, Mohamad M. Kronfol, Matthew S. Halquist, Sara Abudahab, Fay M. Jahr, Elvin T. Price, MaryPeace McRae, Joseph L. McClay, Dayanjan S. Wijesinghe, Mikhail G. Dozmorov
Publikováno v:
Pharmacogenet Genomics
Objectives Phase II drug metabolism is poorly studied in advanced age and older adults may exhibit significant variability in their expression of phase II enzymes. We hypothesized that age-related changes to epigenetic regulation of genes involved in
Autor:
Pamela E. Knapp, Jason J. Paris, Matthew S. Halquist, Woong-Ki Kim, Quamrun N. Masuda, Austin M Jones, Kurt F. Hauser, Angela D. M. Kashuba, Crystal R. Leibrand, MaryPeace McRae
Publikováno v:
J Neurovirol
Poor antiretroviral penetration may contribute to human immunodeficiency virus (HIV) persistence within the brain and to neurocognitive deficits in opiate abusers. To investigate this problem, HIV-1 Tat protein and morphine effects on blood-brain bar
Autor:
Matthew S. Halquist, Fay M. Jahr, Elvin T. Price, Mohamad M. Kronfol, Patricia W. Slattum, MaryPeace McRae, Mikhail G. Dozmorov, Joseph L. McClay, Dayanjan S. Wijesinghe
Phase II drug metabolism is poorly studied in advanced age and older adults may exhibit significant variability in their expression of phase II enzymes. We hypothesized that age-related changes to epigenetic regulation of genes involved in phase II d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55e55f74f721b5d0d237c48b305f445
https://doi.org/10.1101/2020.09.17.300657
https://doi.org/10.1101/2020.09.17.300657
Autor:
Philip M. Gerk, Fay M. Jahr, Karolina A. Aberg, Mikhail G. Dozmorov, Elvin T. Price, Patricia W. Slattum, Palak S. Phansalkar, Joseph L. McClay, Mohamad M. Kronfol, Lin Y. Xie, MaryPeace McRae
Publikováno v:
GeroScience
Aging is associated with reduced liver function that may increase the risk for adverse drug reactions in older adults. We hypothesized that age-related changes to epigenetic regulation of genes involved in drug metabolism may contribute to this effec
Autor:
Katherine Henderson, Teresa M. Salgado, Amy L. Pakyz, Leticia R. Moczygemba, Julie A. Patterson, Benjamin W. Van Tassell, Kai I. Cheang, Jeremy S. Stultz, MaryPeace McRae
Publikováno v:
American journal of pharmaceutical education. 83(8)
Objective. To compare educational outcomes between two iterations of a scholarship and research course for Doctor of Pharmacy (PharmD) students at Virginia Commonwealth University’s School of Pharmacy. Methods. The first iteration of a course inten
Autor:
Matthew S. Halquist, Jakob Green, Xiang-Yang Wang, Shijun Zhang, Chunqing Guo, Yuqi Jiang, Jürgen Venitz, Liu He, Sulay H. Patel, Hallie Blevins, MaryPeace McRae
NLRP3 inflammasomes have recently emerged as an attractive drug target for neurodegenerative disorders. In our continuing studies, a new chemical scaffold was designed as selective inhibitors of NLRP3 inflammasomes. Initial characterization of the le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd697c610d57b5d44ae33c55bee8c2a
https://europepmc.org/articles/PMC6856409/
https://europepmc.org/articles/PMC6856409/