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pro vyhledávání: '"MaryKay Shaw Hes"'
Autor:
R. L. Stanfield, K. L. Hamelehle, Brian R. Krause, Bharat K. Trivedi, A. D. Essenburg, Ann Holmes, Terri S. Purchase, MaryKay Shaw Hes
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:739-747
Our continued interest in developing novel, potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, and our discovery of several active series of disubstituted urea ACAT inhibitors, have led us to investigate a series of trisubstituted ureas t
Autor:
R. L. Stanfield, Bharat K. Trivedi, Brian R. Krause, A. D. Essenburg, K. L. Hamelehle, Terri S. Purchase, Ann Holmes, MaryKay Shaw Hes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2229-2234
A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylureas has been synthesized and evaluated as potential ACAT inhibitors. Most of these analogs are potent inhibitors of ACAT in vitro and lower plasma cholesterol i