Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mary-Margaret O'Donnell"'
Autor:
Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe, Rebecca Cowling, Guixian Jin, Eric S. Manas, Kristi Y. Fan, Michael S. Malamas, Boyd L. Harrison, Steve Jacobsen, Rajiv Chopra, Peter A. Lohse, William J. Moore, Mary-Margaret O’Donnell, Yun Hu, Albert J. Robichaud, M. James Turner, Erik Wagner, Jonathan Bard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:767-771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa246612a7bf5b71fce9eca165375d2
https://doi.org/10.1016/j.bmcl.2007.11.043
https://doi.org/10.1016/j.bmcl.2007.11.043
Autor:
Christopher C. Chadwick, Mary-Margaret O’Donnell, Eugene John Trybulski, Douglas C. Harnish, Mark A. Ashwell, Moore William Jay, Joseph P. Sabatucci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:854-858
The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dafa8b767ce575a06811ad05cc34677
https://doi.org/10.1016/j.bmcl.2005.11.015
https://doi.org/10.1016/j.bmcl.2005.11.015
Autor:
Carmen M. Baldino, Toby J. Underwood, Grace Bi, Wenwei Huang, Mary-Margaret O’Donnell, Andrew Simon Bell, Libing Yu, Jifeng Liu
Publikováno v:
Tetrahedron Letters. 45:8511-8514
Olsson’s three-component reaction of cyclopropylketones, aldehydes, and primary amines was investigated for application to parallel synthesis. Using an excess of Et2AlI at elevated temperatures, pyrrolidines 4 , the initial products reported by Ols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998ad5530ee32caf7970fa66d702f5b1
https://doi.org/10.1016/j.tetlet.2004.09.116
https://doi.org/10.1016/j.tetlet.2004.09.116
Autor:
Christopher J. Verni, Robert J. Tarsa, Adrian Sheldon, David L. Coffen, Carmen M. Baldino, Gary Gustafson, Mary-Margaret O’Donnell
Publikováno v:
Tetrahedron. 54:4051-4065
A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd04f6c8d312812d1c8e6714ae0cbcb8
https://doi.org/10.1016/s0040-4020(98)00134-3
https://doi.org/10.1016/s0040-4020(98)00134-3
Autor:
Robert J. Tarsa, David L. Coffen, Gary Gustafson, Carmen M. Baldino, Christopher J. Verni, Mary-Margaret O’Donnell, Adrian Sheldon
Publikováno v:
ChemInform. 29
A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ffa0cee7d28a2a71de7f3ed9f9082a
https://doi.org/10.1002/chin.199830185
https://doi.org/10.1002/chin.199830185
Autor:
Lee D, Jennings, Derek C, Cole, Joseph R, Stock, Mohani N, Sukhdeo, John W, Ellingboe, Rebecca, Cowling, Guixian, Jin, Eric S, Manas, Kristi Y, Fan, Michael S, Malamas, Boyd L, Harrison, Steve, Jacobsen, Rajiv, Chopra, Peter A, Lohse, William J, Moore, Mary-Margaret, O'Donnell, Yun, Hu, Albert J, Robichaud, M James, Turner, Erik, Wagner, Jonathan, Bard
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The proteolytic enzyme beta-secretase (BACE-1) produces amyloid beta (Abeta) peptide, the primary constituent of neurofibrillary plaques, implicated in Alzheimer's disease, by cleavage of the amyloid precursor protein. A small molecule inhibitor of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f5a0cf47ded12464283a3e5c928baa5
https://pubmed.ncbi.nlm.nih.gov/18068983
https://pubmed.ncbi.nlm.nih.gov/18068983
Autor:
Rocio Palma, Alan Beresford, Mary-Margaret O’Donnell, Donglai Yang, Alex Porte, David Vensel, Manish Tandon, Mark A. Ashwell
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(7)
New arylpiperazines related to buspirone, gepirone and NAN-190 were designed and screened in silico for their 5-HT 1A affinity and potential sites of metabolism by human cytochrome P450 (CYP3A4). Modifications to these structures were assessed in sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d32641721cb8dfb0ddd3530d2cf88
https://pubmed.ncbi.nlm.nih.gov/15026055
https://pubmed.ncbi.nlm.nih.gov/15026055