Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Mary-Lou Pardue"'
Autor:
Institute of Medicine, Board on Health Sciences Policy, Committee on Understanding the Biology of Sex and Gender Differences, Mary-Lou Pardue, Theresa M. Wizemann
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such
Autor:
Mary Lou Pardue, P. G. DeBaryshe
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20317-20324
Reverse transcriptases have shaped genomes in many ways. A remarkable example of this shaping is found on telomeres of the genus Drosophila , where retrotransposons have a vital role in chromosome structure. Drosophila lacks telomerase; instead, thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd248b9caae08c05ba527c9e922ecd9f
https://doi.org/10.1073/pnas.1100278108
https://doi.org/10.1073/pnas.1100278108
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5064-5069
The non-LTR retrotransposons forming Drosophila telomeres constitute a robust mechanism for telomere maintenance, one which has persisted since before separation of the extant Drosophila species. These elements in D. melanogaster differ from nontelom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb6e2a0dd518c03e06618c0346d07b3
https://doi.org/10.1073/pnas.1000612107
https://doi.org/10.1073/pnas.1000612107
Autor:
P. G. DeBaryshe, Mary Lou Pardue
Publikováno v:
Fly. 2:101-110
In Drosophila, the role of telomerase is carried out by three specialized retrotransposable elements, HeT-A, TART and TAHRE. Telomeres contain long tandem head-to-tail arrays of these elements. Within each array, the three elements occur in random, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a6bf9656480e7d9c9fd2ec6a7289b0
https://doi.org/10.4161/fly.6393
https://doi.org/10.4161/fly.6393
Autor:
Mary Lou Pardue
Publikováno v:
Annual Review of Cell and Developmental Biology. 23:1-22
I have been fascinated by chromosomes for longer than I care to mention; their beautiful structure, cell-type-specific changes in morphology, and elegant movements delight me. Shortly before I began graduate study, the development of nucleic acid hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db000833a7f6874c06e227fa4f779bb
https://doi.org/10.1146/annurev.cellbio.23.090506.123459
https://doi.org/10.1146/annurev.cellbio.23.090506.123459
Publikováno v:
Proceedings of the National Academy of Sciences. 104:8391-8396
The retrotransposons that maintain telomeres in Drosophila melanogaster have unique features that are shared across all Drosophila species but are not found in other retrotransposons. Comparative analysis of these features provides insight into their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aa8435b536e7129a2872492ddd8ef0
https://doi.org/10.1073/pnas.0702566104
https://doi.org/10.1073/pnas.0702566104
Publikováno v:
Genome Research. 16:1231-1240
Telomeres of the genus Drosophila, like those of other eukaryotes, are made up of tandem arrays of nucleotide repeats copied from an RNA template. The distinctive feature of Drosophila telomeres lies in the sequence repeats themselves. In all other s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc160336df5e73ad5ec546f896221e3d
https://doi.org/10.1101/gr.5348806
https://doi.org/10.1101/gr.5348806
Autor:
P. G. DeBaryshe, Mary Lou Pardue
Publikováno v:
Annual Review of Genetics. 37:485-511
▪ Abstract Telomere molecular biology is far more complex than originally thought. Understanding biological systems is aided by study of evolutionary variants, and Drosophila telomeres are remarkable variants. Drosophila lack telomerase and the arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4c735a4d1c9e3298b2e30d0a4d094b
https://doi.org/10.1146/annurev.genet.38.072902.093115
https://doi.org/10.1146/annurev.genet.38.072902.093115
Autor:
Elena Casacuberta, Mary Lou Pardue
Publikováno v:
Genetics. 161:1113-1124
As in other eukaryotes, telomeres in Drosophila melanogaster are composed of long arrays of repeated DNA sequences. Remarkably, in D. melanogaster these repeats are produced, not by telomerase, but by successive transpositions of two telomere-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af890ee11bb7e093b190cae994f3e103
https://doi.org/10.1093/genetics/161.3.1113
https://doi.org/10.1093/genetics/161.3.1113