Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mary-Jo Staruch"'
Autor:
Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:447-451
Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058
https://doi.org/10.1016/j.bmcl.2004.10.058
Autor:
Maria L. Garcia, Frank Kayser, Peter J. Sinclair, Mary Jo Staruch, Andrew Kotliar, Nancy N. Tsou, William H. Parsons, Marty S. Springer, Gloria C. Koo, Kathleen M. Rupprecht, William A. Schmalhofer, Gregory J. Kaczorowski, Robert S. Slaughter, Joung L. Goulet, Kashmira Shah, Jianming Bao, Xingfang J. Hong, Frederick Wong, Shouwu Miao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1161-1164
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd33db6982167b726fc36794cabfa008
https://doi.org/10.1016/s0960-894x(03)00014-3
https://doi.org/10.1016/s0960-894x(03)00014-3
Autor:
Owen B. McManus, Gloria C. Koo, Mary Jo Staruch, Mary Matyskiela, Randal M. Bugianesi, Markus Hanner, John P. Felix, William A. Schmalhofer, Denise Wunderler, B G Green, Robert S. Slaughter, Ana-Rosa Linde-Arias, Cristiano G. Ponte, Gregory J. Kaczorowski, Lucia Velasco, Kathleen M. Rupprecht, William H. Parsons, Shouwu Miao, Maria L. Garcia, Jianming Bao
Publikováno v:
Biochemistry. 41:7781-7794
The voltage-gated potassium channel, K(v)1.3, is a novel target for development of immunosuppressants. Using a functional (86)Rb(+) efflux assay, a new class of high-affinity K(v)1.3 inhibitors has been identified. The initial active in this series,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12018acfcca94b56fc83951d2d375b4
https://doi.org/10.1021/bi025722c
https://doi.org/10.1021/bi025722c
Autor:
S Scott, Sandra L. Gould, Jayne Chin, Lorraine Malkowitz, Janet Lineberger, Salvatore J. Siciliano, Julie A. DeMartino, Hollis R. Williams, Lyndon J. Mitnaul, Michael D. Miller, Jerry DiSalvo, Mary Jo Staruch, Douglas W. Kawka, Irwin I. Singer, H J Zweerink, Martin S. Springer, Bruce L. Daugherty
Publikováno v:
Journal of Virology. 75:3779-3790
The chemokine receptors CCR5 and CXCR4 act synergistically with CD4 in an ordered multistep mechanism to allow the binding and entry of human immunodeficiency virus type 1 (HIV-1). The efficiency of such a coordinated mechanism depends on the spatial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd8dc807c3480fd27282da4d0af59a7
https://doi.org/10.1128/jvi.75.8.3779-3790.2001
https://doi.org/10.1128/jvi.75.8.3779-3790.2001
Autor:
Sam L. Koprak, Carolyn DaSilva, Sewell Tonya J, Mary Jo Staruch, Ramon E. Camacho, Gino Salituro, Francis J. Dumont
Publikováno v:
Immunopharmacology. 44:255-265
Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb+PMA and of human PBMC stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1bad61cf8d8e93f53d98bc52e15220
https://doi.org/10.1016/s0162-3109(99)00085-5
https://doi.org/10.1016/s0162-3109(99)00085-5
Autor:
Laurence B. Peterson, Gregory J. Wiederrecht, William H. Parsons, John G. Cryan, Mark A. Holmes, Peter J. Sinclair, Mary-Jo Staruch, Matthew J. Wyvratt, Ray Rosa, Mary Beth Wilusz, Frederick Wong, Mark T. Goulet, Helen M. Armstrong, Francis J. Dumont, Samuel Koprak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2089-2094
The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244384e2a1b2f1fb6064d8a50867dd8e
https://doi.org/10.1016/s0960-894x(99)00336-4
https://doi.org/10.1016/s0960-894x(99)00336-4
Publikováno v:
Cellular Immunology. 190:121-131
Calcineurin (CaN) controls the production of multiple cytokines, including IL-2 and TNF-alpha, during T cell activation. However, its role in chemokine production is unclear. Here, we used the CaN inhibitor FK506 to probe for the contribution of CaN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bde610c0f888e5ad31a80676534798
https://doi.org/10.1006/cimm.1998.1411
https://doi.org/10.1006/cimm.1998.1411
Autor:
Mary Jo Staruch, Salvatore J. Siciliano, Martin S. Springer, Sandra L. Gould, Kristine E. Waldburger, Bruce L. Daugherty, Anna Sirotina-Meisher, Julie A. DeMartino, Youmin Weng
Publikováno v:
Journal of Biological Chemistry. 273:18288-18291
IP10 and MIG are two members of the CXC branch of the chemokine superfamily whose expression is dramatically up-regulated by interferon (IFN)-gamma. The proteins act largely on natural killer (NK)-cells and activated T-cells and have been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36830260799cf0e48d53883728c57d54
https://doi.org/10.1074/jbc.273.29.18288
https://doi.org/10.1074/jbc.273.29.18288
Autor:
Mark T. Goulet, Hyun O. Ok, Mary Jo Staruch, Matthew J. Wyvratt, Francis J. Dumont, Thomas R. Beattie, John Szumiloski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2199-2204
Various C32-amino derivatives were investigated as replacements for the C32-hydroxyl group of ascomycin and its C24-deoxy analog. The syntheses of these amino derivatives and their biological evaluation are reported herein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b77112337017a5aa80d9b72dabe34c00
https://doi.org/10.1016/s0960-894x(97)00409-5
https://doi.org/10.1016/s0960-894x(97)00409-5
Autor:
Matthew J. Wyvratt, Peter J. Sinclair, Greg Wiederrecht, Frederick Wong, Mary Jo Staruch, William H. Parsons, Francis J. Dumont
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2193-2196
The synthesis of naphthyl- and indolyl-ethers of the immunosuppressive macrolide ascomycin using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported. The indole ether analogs show increased immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a25b3ebb53b659c8180d2c0297f39d20
https://doi.org/10.1016/0960-894x(96)00398-8
https://doi.org/10.1016/0960-894x(96)00398-8