Zobrazeno 1 - 10
of 541
pro vyhledávání: '"Mary-Jeanne Kreek"'
Autor:
Nathan Gaddis, Ravi Mathur, Jesse Marks, Linran Zhou, Bryan Quach, Alex Waldrop, Orna Levran, Arpana Agrawal, Matthew Randesi, Miriam Adelson, Paul W. Jeffries, Nicholas G. Martin, Louisa Degenhardt, Grant W. Montgomery, Leah Wetherill, Dongbing Lai, Kathleen Bucholz, Tatiana Foroud, Bernice Porjesz, Valgerdur Runarsdottir, Thorarinn Tyrfingsson, Gudmundur Einarsson, Daniel F. Gudbjartsson, Bradley Todd Webb, Richard C. Crist, Henry R. Kranzler, Richard Sherva, Hang Zhou, Gary Hulse, Dieter Wildenauer, Erin Kelty, John Attia, Elizabeth G. Holliday, Mark McEvoy, Rodney J. Scott, Sibylle G. Schwab, Brion S. Maher, Richard Gruza, Mary Jeanne Kreek, Elliot C. Nelson, Thorgeir Thorgeirsson, Kari Stefansson, Wade H. Berrettini, Joel Gelernter, Howard J. Edenberg, Laura Bierut, Dana B. Hancock, Eric Otto Johnson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling
Externí odkaz:
https://doaj.org/article/a256dcb979ab4a63979d66feec6d2efc
Autor:
Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek, Thomas E. Prisinzano
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)
Abstract Background One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingest
Externí odkaz:
https://doaj.org/article/0172c767eb1349eabd1061749c3e207b
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Several OPRD1 intronic variants were associated with opioid addiction (OD) in a population-specific manner. This follow-up study aims to further characterize the OPRD1 haplotype pattern of the risk variants in different populations and apply
Externí odkaz:
https://doaj.org/article/98434405f53646f1a4b8678c680653ae
Autor:
Alexandra Dolgetta, Megan Johnson, Kate Fruitman, Luke Siegel, Yan Zhou, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner
Publikováno v:
Neurobiology of Stress, Vol 17, Iss , Pp 100431- (2022)
Glutamate receptors have a key role in the neurobiology of opioid addiction. Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 w
Externí odkaz:
https://doaj.org/article/3b28b44451fd4c55ade536f5155b4a41
Autor:
Batsheva R. Rubin, Megan A. Johnson, Jared M. Berman, Ellen Goldstein, Vera Pertsovskaya, Yan Zhou, Natalina H. Contoreggi, Andreina G. Dyer, Jason D. Gray, Elizabeth M. Waters, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100236- (2020)
Following oxycodone (Oxy) conditioned place preference (CPP), delta opioid receptors (DORs) differentially redistribute in hippocampal CA3 pyramidal cells in female and male rats in a manner that would promote plasticity and opioid-associative learni
Externí odkaz:
https://doaj.org/article/5dbdbc6efce8429e9a258232eb7e0889
Autor:
Matthew Randesi, Yan Zhou, Sanoara Mazid, Shannon C. Odell, Jason D. Gray, J. Correa da Rosa, Bruce S. McEwen, Teresa A. Milner, Mary Jeanne Kreek
Publikováno v:
Neurobiology of Stress, Vol 8, Iss , Pp 33-41 (2018)
Opioid peptides and their receptors re-organize within hippocampal neurons of female, but not male, rats following chronic immobilization stress (CIS) in a manner that promotes drug-related learning. This study was conducted to determine if there are
Externí odkaz:
https://doaj.org/article/bee4934bb04d4c8596335143280989ce
Autor:
Matthew Randesi, Orna Levran, Joel Correa da Rosa, Julia Hankins, Jody Rule, Mary Jeanne Kreek, William M. Lee, Adrian Reuben, Robert J. Fontana, Timothy Davern, Brendan McGuire, R. Todd Stravitz, Valerie Durkalski, Iris Liou, Oren Fix, Michael Schilsky, Daniel Ganger, MD, Raymond T. Chung, David Koch, K. Rajender Reddy, Lorenzo Rossaro
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 3, Pp 500-505 (2017)
Background & Aims: Acetaminophen-related acute liver injury and liver failure (ALF) result from ingestion of supratherapeutic quantities of this analgesic, frequently in association with other forms of substance abuse including alcohol, opioids, and
Externí odkaz:
https://doaj.org/article/0f5d788d6c8f42959227c3811a47f447
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224399 (2019)
There is a reciprocal relationship between the circadian and the reward systems. Polymorphisms in several circadian rhythm-related (clock) genes were associated with drug addiction. This study aims to search for associations between 895 variants in 3
Externí odkaz:
https://doaj.org/article/42d7f83dbaad4d879601d0bbf7a3167e
Autor:
Andreas Zimmer, Nurulain Zaveri, Yung H. Wong, Hiroshi Ueda, John R. Traynor, Lawrence Toll, Eric J. Simon, Toni S. Shippenberg, Stefan Schulz, Philip S. Portoghese, Jean-Claude Meunier, Dominique Massot, Davide Malfacini, Lee-Yuan Liu-Chen, Mary-Jeanne Kreek, Ian Kitchen, Brigitte Kieffer, Eamonn Kelly, Stephen Husbands, Graeme Henderson, Volker Höllt, Christopher Evans, Lakshmi A. Devi, Brian M. Cox, Mark Connor, Olivier Civelli, MacDonald J. Christie, Charles Chavkin, Girolamo Caló, Michael Bruchas, Anna Borsodi
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn), nocice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9382e24df4bdd47b46cff68280622f
https://doi.org/10.2218/gtopdb/f50/2023.1
https://doi.org/10.2218/gtopdb/f50/2023.1
Autor:
Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek
Publikováno v:
ACS Chemical Neuroscience. 13:1849-1856
The kappa agonist structure-activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d260aea38567e0609818004c90e457dd
https://doi.org/10.1021/acschemneuro.2c00258
https://doi.org/10.1021/acschemneuro.2c00258