Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Mary-Ellen Harper"'
Autor:
Michel N. Kanaan, Chantal A. Pileggi, Charbel Y. Karam, Luke S. Kennedy, Claire Fong-McMaster, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103213- (2024)
Cysteine, the rate-controlling amino acid in cellular glutathione synthesis is imported as cystine, by the cystine/glutamate antiporter, xCT, and subsequently reduced to cysteine. As glutathione redox is important in muscle regeneration in aging, we
Externí odkaz:
https://doaj.org/article/d63665a9bcdb4a1697b39515309c5096
Autor:
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn
Externí odkaz:
https://doaj.org/article/a0cf0ed0ee2143f0a980d7d5a5c6d50a
Autor:
Bao Kong, Chae Young Han, Se Ik Kim, David A. Patten, Youngjin Han, Euridice Carmona, Dar-Bin Shieh, Annie C. Cheung, Anne-Marie Mes-Masson, Mary-Ellen Harper, Yong Sang Song, Benjamin K. Tsang
Publikováno v:
Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-19 (2022)
Abstract Background Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a di
Externí odkaz:
https://doaj.org/article/323660989fd84e64a77ec0eb5badd778
Autor:
Alexandria Béland-Millar, Alexia Kirby, Yen Truong, Julie Ouellette, Sozerko Yandiev, Khalil Bouyakdan, Chantal Pileggi, Shama Naz, Melissa Yin, Micaël Carrier, Pavel Kotchetkov, Marie-Kim St-Pierre, Marie-Ève Tremblay, Julien Courchet, Mary-Ellen Harper, Thierry Alquier, Claude Messier, Adam J. Shuhendler, Baptiste Lacoste
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112485- (2023)
Summary: Neurovascular abnormalities in mouse models of 16p11.2 deletion autism syndrome are reminiscent of alterations reported in murine models of glucose transporter deficiency, including reduced brain angiogenesis and behavioral alterations. Yet,
Externí odkaz:
https://doaj.org/article/80b98b8bcdd8414481360ac28e85ff5a
Autor:
Chantal A. Pileggi, Gaganvir Parmar, Hussein Elkhatib, Corina M. Stewart, Irina Alecu, Marceline Côté, Steffany A.L. Bennett, Jagdeep K. Sandhu, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100112- (2023)
SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence suggests that SARS-CoV-2 can alter mitochondrial metabolism, suggesting that changes in brain metabolism may contribute to the development of a
Externí odkaz:
https://doaj.org/article/a8e55941bb8b418f8beb33198757c62a
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Autor:
Hang Cheng, Rajaa Sebaa, Nikita Malholtra, Baptiste Lacoste, Ziyad El Hankouri, Alexia Kirby, Nigel C. Bennett, Barry van Jaarsveld, Daniel W. Hart, Glenn J. Tattersall, Mary-Ellen Harper, Matthew E. Pamenter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adi
Externí odkaz:
https://doaj.org/article/a160ac2d7e3742ccace85151b74f2388
Autor:
Ava Liaghati, Chantal A. Pileggi, Gaganvir Parmar, David A. Patten, Nina Hadzimustafic, Alexanne Cuillerier, Keir J. Menzies, Yan Burelle, Mary-Ellen Harper
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Glutathione is an important antioxidant that regulates cellular redox status and is disordered in many disease states. Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that plays a pivotal role in redox control by catalyzing reversible
Externí odkaz:
https://doaj.org/article/b9ee757afd6042619bdf440302b6f161
Autor:
Rajaa Sebaa, Jeff Johnson, Chantal Pileggi, Michaela Norgren, Jian Xuan, Yuka Sai, Qiang Tong, Izabella Krystkowiak, Emma Bondy-Chorney, Norman E. Davey, Nevan Krogan, Michael Downey, Mary-Ellen Harper
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 35-49 (2019)
Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a
Externí odkaz:
https://doaj.org/article/afe2fd5e16c047dbb8b785f6f7720c7f
Autor:
Armand Valsesia, Qiao-Ping Wang, Nele Gheldof, Jérôme Carayol, Hélène Ruffieux, Teleri Clark, Victoria Shenton, Lisa J. Oyston, Gregory Lefebvre, Sylviane Metairon, Christian Chabert, Ondine Walter, Polina Mironova, Paulina Lau, Patrick Descombes, Nathalie Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim H. Saris, Robert Dent, Greg G. Neely, Jörg Hager
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for
Externí odkaz:
https://doaj.org/article/69e3b05bacbb4d4db475ac38f90a9bda
Autor:
Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M. Wishart, Thomas H. Gillingwater, Bernard L. Schneider, Mary-Ellen Harper, Simon H. Parson, Rashmi Kothary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take
Externí odkaz:
https://doaj.org/article/17bff1dec6fd49edbbb066b4aa9e5172