Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Mary-Ellen Cvijic"'
Autor:
Joanna M. Bilak, Gaurav S. Gulsin, Vasiliki Bountziouka, Kelly S. Parke, Emma Redman, Joseph Henson, Lei Zhao, Phillipe Costet, Mary Ellen Cvijic, Juan Maya, Ching-Pin Chang, Melanie J. Davies, Thomas Yates, Gerry P. McCann, Emer M. Brady
Publikováno v:
Hearts, Vol 5, Iss 1, Pp 165-181 (2024)
Background: This study assesses the temporal responses of cardiovascular function, fibro-inflammation, and glucometabolic profiles in asymptomatic adults with type 2 diabetes, following a low-energy meal replacement plan (MRP) or exercise training. M
Externí odkaz:
https://doaj.org/article/d1bb9c4412824338a137d2822d795b4f
Autor:
Abhishek Dattani, Emer M. Brady, Prathap Kanagala, Svetlana Stoma, Kelly S. Parke, Anna-Marie Marsh, Anvesha Singh, Jayanth R. Arnold, Alastair J. Moss, Lei Zhao, Mary Ellen Cvijic, Matthew Fronheiser, Shuyan Du, Philippe Costet, Peter Schafer, Leon Carayannopoulos, Ching-Pin Chang, David Gordon, Francisco Ramirez-Valle, Michael Jerosch-Herold, Christopher P. Nelson, Iain B. Squire, Leong L. Ng, Gaurav S. Gulsin, Gerry P. McCann
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) frequently co-exist. There is a limited understanding on whether this coexistence is associated with distinct alterations in myocardial remodellin
Externí odkaz:
https://doaj.org/article/4215841e5eec4d4b893e3592affdca59
Autor:
Chorom Pak, Kaylene J. Simpson, Andrea D. Weston, Mary Ellen Cvijic, Kenda Evans, Andrew D. Napper
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100146- (2024)
Here we offer perspectives on phenotypic screening based on a wide-ranging discussion entitled “Phenotypic screening, target ID, and multi-omics: enabling more disease relevance in early discovery?” at the Screen Design and Assay Technology Speci
Externí odkaz:
https://doaj.org/article/20c8abe6e30145868863ebbf40d2da1f
Autor:
David Gordon, Kai Hogrefe, Thomas Yates, Anvesha Singh, Leong L Ng, Gerry P McCann, Lei Zhao, Emer M Brady, Hui Xue, John Greenwood, Peter Kellman, Gaurav S Gulsin, Christopher D Steadman, Dana Dawson, Michael Jerosch-Herold, Aseel Alfuhied, Saadia Aslam, Damian Kelly, J Ranjit Arnold, Jian L Yeo, Abhishek Dattani, Marko Banovic, Philippe Costet, Mary Ellen Cvijic, Christina Ebert, Laura Liu, Kushan Gunawardhana, Ching-Pin Chang
Publikováno v:
Open Heart, Vol 10, Iss 2 (2023)
Objective To characterise cardiac remodelling, exercise capacity and fibroinflammatory biomarkers in patients with aortic stenosis (AS) with and without diabetes, and assess the impact of diabetes on outcomes.Methods Patients with moderate or severe
Externí odkaz:
https://doaj.org/article/386c4fdb14d840bdac0f54bac8a4553b
Autor:
E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
Publikováno v:
Journal of Medicinal Chemistry. 65:8843-8854
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92102691c8abe2b69e4c2ddc373e653f
https://doi.org/10.1021/acs.jmedchem.2c00359
https://doi.org/10.1021/acs.jmedchem.2c00359
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 1 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea96b450993c30817e08b09d67ecd09
https://doi.org/10.1158/0008-5472.22377966
https://doi.org/10.1158/0008-5472.22377966
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77108c0dff54d0d9d17df83470660395
https://doi.org/10.1158/0008-5472.22377963.v1
https://doi.org/10.1158/0008-5472.22377963.v1
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Figure and Table Legends 1-2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c30c0ceeb3ee6de838292a026446d0
https://doi.org/10.1158/0008-5472.22377969
https://doi.org/10.1158/0008-5472.22377969
Autor:
Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
Publikováno v:
Journal of Medicinal Chemistry. 64:15549-15581
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clinical compound BMS-986020 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256
https://doi.org/10.1021/acs.jmedchem.1c01256
Autor:
Anne Rose, Qihong Zhao, Kumaravel Selvakumar, Percy H. Carter, Prakash Anjanappa, Jing Chen, Sandhya Mandlekar, Mary Ellen Cvijic, Andrew J. Tebben, Songmei Xu, Gregory D. Brown, Venkatram Reddy Paidi, Arvind Mathur, Douglas G. Batt, Jian Pang, Joel C. Barrish, Robert J. Cherney, Melissa Yarde, Ragini Vuppugalla
Publikováno v:
ACS Med Chem Lett
[Image: see text] BMS-813160 (compound 3) was identified as a potent and selective CCR2/5 dual antagonist. Compound 3 displayed good permeability at pH = 7.4 in PAMPA experiments and demonstrated excellent human liver microsome stability. Pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0c6d25f05a8ec4cbd4e45bae9db09
https://doi.org/10.1021/acsmedchemlett.1c00373
https://doi.org/10.1021/acsmedchemlett.1c00373