Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mary X Ho"'
Autor:
Yu Zhang, David Degen, Mary X Ho, Elena Sineva, Katherine Y Ebright, Yon W Ebright, Vladimir Mekler, Hanif Vahedian-Movahed, Yu Feng, Ruiheng Yin, Steve Tuske, Herbert Irschik, Rolf Jansen, Sonia Maffioli, Stefano Donadio, Eddy Arnold, Richard H Ebright
Publikováno v:
eLife, Vol 3 (2014)
Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center ‘i’ and ‘i+1’ nucleotide binding sites, preven
Externí odkaz:
https://doaj.org/article/f4f3d502427d47b09fde0b71d754abf6
Publikováno v:
Current Opinion in Structural Biology. 19:715-723
Inhibition of bacterial RNA polymerase (RNAP) is an established strategy for antituberculosis therapy and broad-spectrum antibacterial therapy. Crystal structures of RNAP-inhibitor complexes are available for four classes of antibiotics: rifamycins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11e3356a557fdbc603947e0f94a60c4
https://doi.org/10.1016/j.sbi.2009.10.010
https://doi.org/10.1016/j.sbi.2009.10.010
Autor:
Yon W. Ebright, Vladimir Mekler, Rolf Jansen, Eddy Arnold, Ruiheng Yin, Yu Zhang, Richard H. Ebright, Herbert Irschik, Katherine Y. Ebright, Yu Feng, Hanif Vahedian-Movahed, Elena V. Sineva, Steve Tuske, Stefano Donadio, Mary X. Ho, Sonia I. Maffioli, David Degen
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center ‘i’ and ‘i+1’ nucleotide binding sites, preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d307835b91cb51d4efe8c0f4bd382a
https://doi.org/10.7554/elife.02450
https://doi.org/10.7554/elife.02450
Autor:
Richard H. Ebright, Sujoy Chatterjee, Yu Feng, Eddy Arnold, Yu Zhang, Steve Tuske, Mary X. Ho
Class II transcription activators function by binding to a DNA site overlapping a core promoter and stimulating isomerization of an initial RNA polymerase (RNAP)–promoter closed complex into a catalytically competent RNAP-promoter open complex. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061d8739305cf6eff72cf162025648de
https://europepmc.org/articles/PMC3593053/
https://europepmc.org/articles/PMC3593053/
