Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mary Woodall Jappe"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionRegulatory T cell (Treg)-targeting cancer immunotherapy aims to transiently deplete Treg cells in the tumor microenvironment, without affecting effector T cells (Teff), thus both enhancing anti-tumor activity and avoiding autoimmunity. Th
Externí odkaz:
https://doaj.org/article/c25ee8c9bb24464ebab7d9dc7200886e
Autor:
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging a
Externí odkaz:
https://doaj.org/article/0260063af8414162a61d45c6971191f1
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/7a133fa480894f00b51d476c3ad34212
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c65eb6f8b62874049a2fbbb2e9b798
https://doi.org/10.1158/1535-7163.22504099.v1
https://doi.org/10.1158/1535-7163.22504099.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702da5e1eb71b2ce4a697dd456e12e0
https://doi.org/10.1158/1535-7163.c.6537622.v1
https://doi.org/10.1158/1535-7163.c.6537622.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f53f6e76b6cb66b04a95e5af1c1cb98
https://doi.org/10.1158/1535-7163.22504102
https://doi.org/10.1158/1535-7163.22504102
Autor:
Diana I. Albu, Zichun Wang, Kuan-Chun Huang, Jiayi Wu, Natalie Twine, Sarah Leacu, Christy Ingersoll, Lana Parent, Winnie Lee, Diana Liu, Renee Wright-Michaud, Namita Kumar, Galina Kuznetsov, Qian Chen, Wanjun Zheng, Kenichi Nomoto, Mary Woodall-Jappe, Xingfeng Bao
Publikováno v:
OncoImmunology, Vol 6, Iss 8 (2017)
Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived suppressor cells (MDSC), and regulatory T cells (Tregs), represents a promising strategy for de
Externí odkaz:
https://doaj.org/article/0ad9b21d212e459193839200090fcdbd
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Regulatory T cell (Tregs) inhibit activity of anti-tumor T cells, and have been shown to limit checkpoint inhibitor effectiveness. Depletion of Tregs seems desirable during immunotherapy, but chronic Treg depletion with antibody therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f453a606159fe5d180c787f9f2473c4
https://doaj.org/article/7a133fa480894f00b51d476c3ad34212
https://doaj.org/article/7a133fa480894f00b51d476c3ad34212
Autor:
Kenichi Nomoto, Kuo Ming Wu, Xiaojie Zhu, Sergei Agoulnik, Donna Kolber-Simonds, Kuan-Chun Huang, Steven Mathieu, Toshimitsu Uenaka, Sandeep Akare, Yongchun Shen, Yoshihiko Kotake, William H. Gerwick, Zhihong Chen, Hyeong-Wook Choi, Karen TenDyke, Yimin Jiang, Krista Condon, Mary Woodall-Jappe, Hajime Shimizu
Publikováno v:
Molecular Cancer Therapeutics. 15:1208-1216
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5b7bfdb06dfb6c13edeb29b73304c4
https://doi.org/10.1158/1535-7163.mct-15-0648
https://doi.org/10.1158/1535-7163.mct-15-0648
Publikováno v:
Cancer Research. 80:5522-5522
Eribulin, a synthetic analog of the marine sponge natural product halichondrin B, is approved in the US for certain patients with advanced breast cancer or liposarcoma. Its mechanisms of action include both cytotoxic, antimitotic effects as well as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0afb330c35a8b2fb03ec82ba2e57b85a
https://doi.org/10.1158/1538-7445.am2020-5522
https://doi.org/10.1158/1538-7445.am2020-5522