Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mary Waltner-Law"'
Publikováno v:
Journal of Ethnopharmacology. 96:295-301
Insulin action is impaired in diabetic patients, which leads to increased hepatic glucose production. Plants and herbs have been used for medicinal purposes, including the treatment of diabetes, for centuries. Since dietary management is a starting p
Autor:
Marc C. Daniels, Birger Herzog, Xiaohui L. Wang, Ratna Prasad, Daryl K. Granner, David T. Duong, Mary Waltner-Law
Publikováno v:
Journal of Biological Chemistry. 278:10427-10435
Although many genes are regulated by the concerted action of several hormones, hormonal signaling to gene promoters has generally been studied one hormone at a time. The phosphoenolpyruvate carboxykinase (PEPCK) gene is a case in point. Transcription
Autor:
Cassondra Covington, Anna Chytil, Harold L. Moses, Nancy Dumont, Mary Aakre, Elizabeth G. Hamilton, Brian K. Law, Mary Waltner-Law
Publikováno v:
Molecular and Cellular Biology. 22:8184-8198
Transforming growth factor beta (TGF-beta) induces cell cycle arrest of most nontransformed epithelial cell lines. In contrast, many human carcinomas are refractory to the growth-inhibitory effect of TGF-beta. TGF-beta overexpression inhibits tumorig
Autor:
Mary Waltner-Law, Masao Nawano, Robert K. Hall, Brian K. Law, Daryl K. Granner, Xiaohui L. Wang
Publikováno v:
Journal of Biological Chemistry. 277:34933-34940
Herbs have been used for medicinal purposes, including the treatment of diabetes, for centuries. Plants containing flavonoids are used to treat diabetes in Indian medicine and the green tea flavonoid, epigallocatechin gallate (EGCG), is reported to h
Publikováno v:
Journal of Biological Chemistry. 277:32234-32242
Hormones regulate glucose homeostasis, in part, by controlling the expression of gluconeogenic enzymes, such as phosphoenolpyruvate carboxykinase (PEPCK). Insulin and glucocorticoids reciprocally regulate PEPCK expression primarily at the level of ge
Publikováno v:
Journal of Biological Chemistry. 277:26098-26102
Glucocorticoids cause a 10-fold increase in hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene transcription through two low affinity glucocorticoid receptor (GR) binding sites and a complex array of accessory factor DNA elements and associated p
Publikováno v:
Protein Science. 11:1026-1035
Most mitochondrial matrix space proteins are synthesized as a precursor protein, and the N-terminal extension of amino acids that served as the leader sequence is removed after import by the action of a metalloprotease called mitochondrial processing
Publikováno v:
Journal of Biological Chemistry. 276:3811-3819
In the liver, glucocorticoids induce a 10-15-fold increase in the rate of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene, which encodes a key gluconeogenic enzyme. This induction requires a multicomponent glucocorticoid response
Autor:
Peter Nørgaard, Mary Waltner-Law, Anna Chytil, Mary Aakre, Brian K. Law, Amelia J. Entingh, Harold L. Moses
Publikováno v:
Journal of Biological Chemistry. 275:38261-38267
Salicylate and its pro-drug form aspirin are widely used medicinally for their analgesic and anti-inflammatory properties, and more recently for their ability to protect against colon cancer and cardiovascular disease. Despite the wide use of salicyl
Publikováno v:
Journal of Biological Chemistry. 275:31847-31856
Transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene is regulated by a variety of agents. Glucocorticoids, retinoic acid, and glucagon (via its second messenger, cAMP) stimulate PEPCK gene transcription, whereas insulin, phorbol esters