Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mary W, Walker"'
Autor:
Gamini Chandrasena, J. John Mann, Jaya Prabhakaran, Mathivanan Packiarajan, Vrej Jubian, J. S. Dileep Kumar, Mali Pratap, Ramin V. Parsey, Mary W. Walker
Publikováno v:
ACS chemical neuroscience. 7(5)
Neuropeptide Y receptor type 5 (NPY5R) is a G-protein coupled receptor (GPCR) that belongs to the subfamily of neuropeptide receptors (NPYR) that mediate the action of endogenous neuropeptide Y (NPY). Animal models and preclinical studies indicate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5450a282121e7e2c6ba51dcc88d3df94
https://pubmed.ncbi.nlm.nih.gov/26886507
https://pubmed.ncbi.nlm.nih.gov/26886507
Autor:
Laxminarayan G. Hegde, Mary W. Walker, Vrej Jubian, Mariusz Papp, Mohammad R. Marzabadi, Douglas A. Craig, Christophe P. G. Gerald, David H. Overstreet, Silke Miller, Gamini Chandrasena, Huailing Zhong, Toni D. Wolinsky, Douglas A. Marsteller, Xinyan Huang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:900-911
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y1, Y2, Y4, Y5, and y6). The Y5 receptor is well known for its role in appetite. Based on expression in the limbic system, we hypothesized that the Y5 receptor might also m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152b8da161e9f077a50457dd9cc641dc
https://doi.org/10.1124/jpet.108.144634
https://doi.org/10.1124/jpet.108.144634
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1771-1774
A series of sulfonamide neuropeptide Y Y5 antagonists was optimized by preparation of sets of analogues using high-throughput synthesis and purification techniques. Testing of these compounds for their ability to bind to the human NPY Y5 receptor rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4548bebe4333f09c318e11afcd90295
https://doi.org/10.1016/s0960-894x(02)00288-3
https://doi.org/10.1016/s0960-894x(02)00288-3
Autor:
Christophe P. G. Gerald, Kelli E. Smith, Theresa Branchek, Eric L. Gustafson, Mary W. Walker, Margaret M. Durkin
Publikováno v:
Experimental Neurology. 165:90-100
Our group has reported on the cloning of a novel rat neuropeptide Y (NPY) receptor involved in NPY-induced food intake, the Y5 receptor. The distribution in rat brain of the mRNA encoding this receptor has been determined by in situ hybridization his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c5d13130d8466127aa3b4fe85e6108
https://doi.org/10.1006/exnr.2000.7446
https://doi.org/10.1006/exnr.2000.7446
Autor:
Dale Dhanoa, Pascal Rigollier, Tibur Schmidlin, Imadul Islam, Mary W. Walker, Walter Schilling, Heinrich Rueeger, Michele Chiesi, Steven Whitebread, Jack Zhang, Yasuchika Yamaguchi, Charles Gluchowski, Leoluca Criscione
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1175-1179
The design of a novel series of NPY-Y5 receptor antagonists is described. Key elements for the design were the identification of weak Y5 hits from a Y1 program, results from a combinatorial approach and database mining. This led to the discovery of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a78386bd5b5a50ca962cbfb418b445
https://doi.org/10.1016/s0960-894x(00)00177-3
https://doi.org/10.1016/s0960-894x(00)00177-3
Publikováno v:
Annals of the New York Academy of Sciences. 863:94-107
Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to galanin and galanin-like peptides in vitro and in vivo. The recent application of molecular biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9588c12156f337fb9411a7d4e26d248
https://doi.org/10.1111/j.1749-6632.1998.tb10687.x
https://doi.org/10.1111/j.1749-6632.1998.tb10687.x
Autor:
Pierre J.-J. Vaysse, Jonathan A. Bard, Wen-Jeng Yao, Christophe P. G. Gerald, Roman Artymyshyn, Beth Borowsky, Kelli E. Smith, Joseph A. Tamm, Theresa Branchek, Mary W. Walker, Kenneth A. Jones
Publikováno v:
Journal of Biological Chemistry. 273:23321-23326
The neuropeptide galanin has been implicated in the regulation of processes such as nociception, cognition, feeding behavior, and hormone secretion. Multiple galanin receptors are predicted to mediate its effects, but only two functionally coupled re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bd37bf546696b371e37cc270d74773
https://doi.org/10.1074/jbc.273.36.23321
https://doi.org/10.1074/jbc.273.36.23321
Autor:
Christophe P. G. Gerald, Jonathan A. Bard, Kelli E. Smith, Beth Borowsky, Kenneth A. Jones, Ling-Yan Huang, Mary W. Walker, Theresa Branchek
Publikováno v:
Peptides. 19:1771-1781
We present the molecular cloning and characterization of the human galanin receptor, hGALR2. hGALR2 shares 85%, 39%, and 57% amino acid identities to rGALR2, hGALR1, and hGALR3, respectively. hGALR2, along with rGALR2, can be distinguished from the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247edf96a3c90cbf25ef537d1d4f1282
https://doi.org/10.1016/s0196-9781(98)00133-8
https://doi.org/10.1016/s0196-9781(98)00133-8
Autor:
Carlos Forray, Jonathan A. Bard, Joseph A. Tamm, Mary W. Walker, David L. Linemeyer, Kelli E. Smith, Kenneth A. Jones, Theresa Branchek, Christophe P. G. Gerald
Publikováno v:
Journal of Biological Chemistry. 272:24612-24616
The neuropeptide galanin is widely distributed throughout the central and peripheral nervous systems and participates in the regulation of processes such as nociception, cognition, feeding behavior, and insulin secretion. Multiple galanin receptors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aabb2a0028703beeebd34d802d6d7cf
https://doi.org/10.1074/jbc.272.39.24612
https://doi.org/10.1074/jbc.272.39.24612
Autor:
Jonathan A. Bard, Sherif Daouti, Pierre J.-J. Vaysse, Kelli E. Smith, Theresa Branchek, Mary W. Walker, Richard L. Weinshank, Christophe P. G. Gerald
Publikováno v:
Peptides. 18:609-612
We cloned and expressed the rat Y4 receptor for pancreatic polypeptide (PP). Structure-activity profiles derived from 125I-PP binding assays and [cAMP] radioimmunoassays reveal a selective receptor interaction with rat PP vs. neuropeptide Y (NPY) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fad780476a62e6267acb68f309c2711
https://doi.org/10.1016/s0196-9781(97)00070-3
https://doi.org/10.1016/s0196-9781(97)00070-3