Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mary W, Burney"'
Autor:
Rhonda M Lachance, Stephen R. Rapp, John J. Parlow, Peter Harris, Rita M. Huff, Case Brenda, Mary W. Burney, Thomas J. Girard, Deborah A. Mischke, Ennis Michael D, Rhonda S. Woerndle, Kerri A. Hall, Ronald R. Hiebsch
Publikováno v:
Journal of Medicinal Chemistry. 53:2010-2037
Polymer-assisted solution-phase (PASP) parallel library synthesis was used to discover a piperazinyl glutamate pyridine as a P2Y(12) antagonist. Exploitation of this lead provided compounds with excellent inhibition of platelet aggregation as measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f6174166fe97444d9135003e4fe44c
https://doi.org/10.1021/jm901518t
https://doi.org/10.1021/jm901518t
Autor:
John J, Parlow, Mary W, Burney, Brenda L, Case, Thomas J, Girard, Kerri A, Hall, Peter K, Harris, Ronald R, Hiebsch, Rita M, Huff, Rhonda M, Lachance, Deborah A, Mischke, Stephen R, Rapp, Rhonda S, Woerndle, Michael D, Ennis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1388-1394
Efforts to refine the SAR of the piperazinyl-glutamate-pyridines for more potent analogs with improved pharmacokinetic profiles are described. Exploring substituted piperidines and other ring systems at the 4-pyridyl position led to compounds with im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa8e3393275c3b43dc35183d05b48db
https://doi.org/10.1016/j.bmcl.2009.12.110
https://doi.org/10.1016/j.bmcl.2009.12.110
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation
Autor:
Kerri A. Hall, Rita M. Huff, Rhonda M. Lachance, Ennis Michael D, Rhonda S. Woerndle, Ronald R. Hiebsch, John J. Parlow, Stephen R. Rapp, Deborah A. Mischke, Brenda L. Case, Mary W. Burney, Thomas J. Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6148-6156
Piperazinyl-glutamate-pyrimidines were prepared with oxygen, nitrogen, and sulfur substitution at the 4-position of the pyrimidine leading to highly potent P2Y 12 antagonists. In particular, 4-substituted piperidine-4-pyrimidines provided compounds w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da90bff048b77255c54d7a7a094fdeb9
https://doi.org/10.1016/j.bmcl.2009.09.017
https://doi.org/10.1016/j.bmcl.2009.09.017
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 282:E650-E656
Anorexia and weight loss are frequent complications of acute and chronic infections and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. Selective attenuation of the hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1c87f59a1ca2b051f63e30b6f47910
https://doi.org/10.1152/ajpendo.00388.2001
https://doi.org/10.1152/ajpendo.00388.2001
Publikováno v:
Journal of Virology. 73:3682-3691
Human cytomegalovirus (HCMV) infection of immunocompromised people or neonates can cause significant morbidity and mortality, while infection of normal hosts typically causes asymptomatic, although lifelong, infection (18, 45, 47, 54). The ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6021cfcfddfb186a162113c208ab59e6
https://doi.org/10.1128/jvi.73.5.3682-3691.1999
https://doi.org/10.1128/jvi.73.5.3682-3691.1999
Autor:
Mary W. Burney, Ted Baginski, Fei Shih, Stephen R. Rapp, Holly Meade, Kimberly Shevlin, Dean Welsch, Mike Baratta, Deborah Knoerzer, Sharon Rouw
Publikováno v:
D61. ANIMAL MODELS OF PULMONARY ARTERIAL HYPERTENSION: NEW IDEAS AND INSIGHTS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5414e4bc5fd49777a15cc7eedb5c7bb4
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6308
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6308
Autor:
Dean Welsch, Mary W. Burney, Stephen R. Rapp, Deborah Knoerzer, Ted Baginski, Kimberly Wade, Connie Fan, Joe Palandra, Karen Regina, Fei Shih, Sharon Rouw
Publikováno v:
A58. ANIMAL MODELS OF PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5d57f0fdf5727927767ec8af8d8795
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2000
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2000
Autor:
Ted Baginski, Connie Fan, Fei Shih, Deborah Knoerzer, Stephen R. Rapp, Karen Regina, Sharon Rouw, Kimberly Wade, Mary W. Burney, Dean Welsch
Publikováno v:
A58. ANIMAL MODELS OF PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89021b31f353c924ac942bbb33e58b08
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2001
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2001
Autor:
Peter Harris, Kerri A. Hall, Mary W. Burney, Thomas J. Girard, Stephen R. Rapp, Rita M. Huff, Ronald R. Hiebsch, Rhonda M Lachance, Case Brenda, Ennis Michael D, Rhonda S. Woerndle, Deborah A. Mischke, John J. Parlow
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Polymer-assisted solution-phase (PASP) parallel library synthesis was used to discover a piperazinyl glutamate pyridine as a P2Y12 antagonist. Exploitation of this lead provided compounds with excellent inhibition of platelet aggregation as measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af70aba9ebebe44b65412105d0dcebc
https://pubmed.ncbi.nlm.nih.gov/19604694
https://pubmed.ncbi.nlm.nih.gov/19604694
Publikováno v:
Biochemical and biophysical research communications. 302(2)
3T3-L1 adipocytes have proven difficult to transfect with plasmid-encoded cDNAs or even infect with virally-derived cDNAs. We have developed and characterized a 3T3-L1 adipocyte cell line stably expressing the truncated receptor for coxsackievirus an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b95157de14a5c5e0fde7c778473102
https://pubmed.ncbi.nlm.nih.gov/12604354
https://pubmed.ncbi.nlm.nih.gov/12604354