Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mary V. Nekola"'
Publikováno v:
Biochemical and Biophysical Research Communications. 124:217-222
The aim of this study was to investigate whether anterior pituitary responsiveness to human pancreatic growth hormone-releasing factor containing 29 amino acids (GRF-29) can be modulated by GRF-29 itself. Male rats were injected (sc) daily for 3 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0079d5903b5ade92cbc04b8f240364
https://doi.org/10.1016/0006-291x(84)90939-2
https://doi.org/10.1016/0006-291x(84)90939-2
Publikováno v:
Biology of Reproduction. 24:505-511
Immature female rats were treated with D-Trp’-LHRH to determine if the delay in vaginal opening induced by the superactive agonist of LHRH could be correlated with changes in ACTH, prolactin, or corticosterone levels. The rats were injected daily f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9f4532f951352f1fa63c7cdc73807c
https://doi.org/10.1095/biolreprod24.3.505
https://doi.org/10.1095/biolreprod24.3.505
Autor:
Mary V. Nekola
Publikováno v:
Biology of Reproduction. 23:988-993
The capacity of rat oocytes to mature in vitro was studied in relationship to the stages of the 4and 5-day estrous cycles and to the time of day. Antral oocytes obtained from animals on regular 4- and 5-day cycles were placed in culture under standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a65f1444609d5a26b2d53ce37230eb
https://doi.org/10.1095/biolreprod23.5.988
https://doi.org/10.1095/biolreprod23.5.988
Publikováno v:
International Archives of Allergy and Immunology. 84:316-320
The cutaneous anaphylactoid test was evaluated as a screen for assessing mast cell mediator-releasing (MCMR) activity of luteinizing hormone-releasing hormone (LHRH) peptides. As expected, LHRH and D-Trp6-LHRH, an agonist of LHRH, were nonreactive at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3245b59897d9145a7eafedd2e75fc20
https://doi.org/10.1159/000234441
https://doi.org/10.1159/000234441
Publikováno v:
Journal of Medicinal Chemistry. 31:1820-1824
The effect of the CH2NH and CH2NAc peptide bond isosteres on the antagonistic and histamine releasing activities of the LH-RH antagonist [N-Ac-D-Nal1,D-Phe2,3,D-Arg6,Phe7,D-Ala10] LH-RH was investigated. The moieties were introduced by facile, racemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce3f236f246d13ced6d3cbf253dd78b
https://doi.org/10.1021/jm00117a024
https://doi.org/10.1021/jm00117a024
Autor:
Judit Erchegyi, Mary V. Nekola, Esther J. Coy, Aniko Horvath, David H. Coy, Andrew V. Schally
Publikováno v:
Endocrinology. 110:1445-1447
It has been assumed, usually with good reason, that D-amino acids with large aromatic side-chains must be present in position 6 of both LH-RH superagonists and antagonists for the highest levels of biological activity to be reached. However, using on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa24d55b947a6b7a85ec35dd972cee
https://doi.org/10.1210/endo-110-4-1445
https://doi.org/10.1210/endo-110-4-1445
Publikováno v:
Peptides. 3:969-971
As part of our studies on the design of more potent antagonists of the LH-RH (luteinizing hormone-releasing hormone) decapeptide, twelve new highly soluble D-Arg 6 -analogs have been synthesized. These peptides contain modifications in position 1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1cbcfb40a207a29d46f208fa8cf577
https://doi.org/10.1016/0196-9781(82)90066-3
https://doi.org/10.1016/0196-9781(82)90066-3
Publikováno v:
Journal of medicinal chemistry. 30(4)
The reductive alkylation of the D-Lys side chain in position 6 of the LH-RH antagonist [N-Ac-D-Nal1,D-Phe2,3,D-Arg6,Phe7,D-Ala10]LH-RH was investigated in an attempt to reduce the histamine-releasing activity inherent to most potent antagonists while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b187940849d926097b1511c8977108
https://pubmed.ncbi.nlm.nih.gov/2435906
https://pubmed.ncbi.nlm.nih.gov/2435906
Autor:
Mary V. Nekola, Dianne Moore Smith
Publikováno v:
The Journal of experimental zoology. 194(3)
In sufficient concentration, dibutyryl cAMP (DBC) prevents the spontaneous in vitro maturation of mouse oocytes. The effects of luteinizing hormone (LH) and follicle stimulating hormone (FSH) on this inhibition were tested in an oil-free chamber-slid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7ca4121ac5a335f1c5df74c10b4b0c
https://pubmed.ncbi.nlm.nih.gov/172590
https://pubmed.ncbi.nlm.nih.gov/172590
Publikováno v:
Journal of medicinal chemistry. 30(4)
The structure-activity relationship of the hydrophobic amino terminal region of the antagonist [N-Ac-D-Nal1,D-pClPhe2,D-Trp3,D-Arg6,Phe7,D-Ala10]-LH- RH has been investigated by the incorporation of a variety of amino acids with emphasis on positions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f359b1118322381f101323279878c42
https://pubmed.ncbi.nlm.nih.gov/3550087
https://pubmed.ncbi.nlm.nih.gov/3550087