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Autor:
John Erickson, David J. Neidhart, John VanDrie, Dale J. Kempf, Xiu Chun Wang, Daniel W. Norbeck, Jacob J. Plattner, Judith W. Rittenhouse, Mary Turon, Norman Wideburg, William E. Kohlbrenner, Robert Simmer, Rosalind Helfrich, Deborah A. Paul, Mark Knigge
Publikováno v:
Science. 249:527-533
A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and