Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Mary Treinen-Moslen"'
Autor:
Mary F. Kanz, Mary Treinen-Moslen
Publikováno v:
Pharmacology & Therapeutics. 112:649-667
Drug secretion into bile is typically considered a safe route of clearance. However, biliary delivery of some drugs or their reactive metabolites to the intestinal tract evokes adverse consequences due to direct toxic actions or indirect disruption o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327e7ba9197dbef41e0c863e50b25456
https://doi.org/10.1016/j.pharmthera.2006.05.007
https://doi.org/10.1016/j.pharmthera.2006.05.007
Publikováno v:
Journal of Chromatography B. 830:231-237
A rapid and sensitive high-performance liquid chromatographic method was developed for determination of diclofenac and its major metabolite, 4'-hydroxydiclofenac, in serum from rats treated with diclofenac. The method is simple with a one-step extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0f4cd265b17b8ee6d12aa833ec1154
https://doi.org/10.1016/j.jchromb.2005.10.045
https://doi.org/10.1016/j.jchromb.2005.10.045
Autor:
Veronica Ramirez-Alcantara, Gilberto Castañeda-Hernández, Mary Treinen-Moslen, Bill A. Rampy, Judith F. Aronson
Publikováno v:
Drug Development Research. 64:19-27
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) widely prescribed for pain and inflammation. Theoretically, the gastrointestinal (GI) complications of diclofenac could be minimized by administering a diclofenac resinate formulation, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c8a034a90255d78afc3763f7c0067d
https://doi.org/10.1002/ddr.10417
https://doi.org/10.1002/ddr.10417
Publikováno v:
Chemical Research in Toxicology. 16:1306-1317
A proteome profiling approach was used to compare effects of two toxicants, 1,1-dicloroethylene (DCE) and diclofenac, which covalently adduct hepatic proteins. Bile was examined as a potential source of protein alterations since both toxicants target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbf3fb2377611b0667adfd7cb141f61
https://doi.org/10.1021/tx0340807
https://doi.org/10.1021/tx0340807
Publikováno v:
Comments on Toxicology. 9:229-249
MRP2, a multidrug resistance-associated protein, helps to maintain mammalian homeostasis by exporting bilirubin conjugates and many xenobiotics into bile or urine. Experiments with two mutant rat strains, namely TR− and EHBR which have a functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d42f739b5e9bf33d19a67ff7945a56
https://doi.org/10.1080/08865140390427454
https://doi.org/10.1080/08865140390427454
Autor:
Davis H. Daiker, Jonathan B. Ward, Shipp Bk, Schoenfeld Ha, Mary Treinen Moslen, Gisela Witz, Klimpel Gr
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 59:181-196
Potential additive effects of ethanol consumption, a common life-style factor, and low-level benzene exposure, a ubiquitous environmental pollutant, were investigated. Ethanol is a potent inducer of the cytochrome P-450 2E1 (CYP2E1) enzyme, which bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a375bf6242dff49525372af8ee1588
https://doi.org/10.1080/009841000156961
https://doi.org/10.1080/009841000156961
Publikováno v:
International Journal of Toxicology. 18:327-335
Although the CD-1 mouse strain has been used to investigate the toxicity of numerous substrates of Cyp2e1, limited information is available about responses of this strain to ethanol, a potent and clinically relevant inducer of this cytochrome P450 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a66574cb55b611fc8a1f686299b1500
https://doi.org/10.1080/109158199225242
https://doi.org/10.1080/109158199225242
Publikováno v:
Toxicology. 96:217-224
Biotransformation of 2-methoxyethanol (2-ME) by alcohol and aldehyde dehydrogenases is an established factor in the toxicity of this useful solvent. Little is known about potential capacity for 2-ME biotransformation by testis or other target tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9409f2b0ce549c66e736519073becd29
https://doi.org/10.1016/0300-483x(94)02921-g
https://doi.org/10.1016/0300-483x(94)02921-g
Autor:
Mary Treinen-Moslen, Justin C. Frey, Paul J. Boor, Arun Balakumaran, Joshua K. Salabei, Daniel J. Conklin
Publikováno v:
Toxicology and applied pharmacology. 262(3)
Calcium channel blockers (CCBs) are important in the management of hypertension and limit restenosis. Although CCB efficacy could derive from decreased blood pressure, other mechanisms independent of CCB activity also can contribute to antiproliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254d6870500ad5063775a35f6a525c72
https://pubmed.ncbi.nlm.nih.gov/22627060
https://pubmed.ncbi.nlm.nih.gov/22627060
Publikováno v:
Experimental and Molecular Pathology. 61:1-15
We studied the effects of a transient elevation in biliary pressure on biliary glutathione and amino acids in rats. Other biliary solutes monitored were total bile salt, Pi, which is a putative marker of paracellular leakage, and glucose, which is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e6143d94228aff137b207d32edbcc
https://doi.org/10.1006/exmp.1994.1021
https://doi.org/10.1006/exmp.1994.1021