Výsledky vyhledávání

The roles of twoC. elegansHOX co-factor orthologs in cell migration and vulva development

Autor: Mary Sym, Lucie Yang, Cynthia Kenyon

Publikováno v: Development. 132:1413-1428

Anteroposterior cell migration and patterning in C. elegans are governed by multiple, interacting signaling pathways and transcription factors. In this study, we have investigated the role of ceh-20, the C. elegans ortholog of the HOX co-factor Extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3a2b19fd75d34ae929db1e968a4fac
https://doi.org/10.1242/dev.01569

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Publikováno v: Developmental Cell. 3(1):85-97

Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11bca1732c82c37329da15ad8aa1ce

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MIG-13 Positions Migrating Cells along the Anteroposterior Body Axis of C. elegans

Autor: Naomi Robinson, Mary Sym, Cynthia Kenyon

Publikováno v: Cell. 98:25-36

The C. elegans Q neuroblasts and their descendants migrate along the anteroposterior (A/P) body axis to positions that are not associated with any obvious landmarks. We find that a novel protein, MIG-13, is required to position these cells correctly.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5b28c4d0bcd2143615b59ecb427238
https://doi.org/10.1016/s0092-8674(00)80603-0

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ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis

Autor: G. Shirleen Roeder, JoAnne Engebrecht, Mary Sym

Publikováno v: Cell. 72:365-378

ZIP1 is a novel meiosis-specific gene required for chromosome synapsis and cell cycle progression in S. cerevisiae. zip1 strains undergo homologous chromosome pairing, but are defective in synaptonemal complex (SC) formation. The zip1 mutation confer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309c74e3970b7d649d1e19fcad301e86
https://doi.org/10.1016/0092-8674(93)90114-6

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A model for Niemann–Pick type C disease in the nematode Caenorhabditis elegans

Autor: Michael Basson, Carl Hirschie Johnson, Mary Sym

Publikováno v: Current Biology. (9):527-530

Niemann–Pick type C (NP-C) disease is a progressive neurodegenerative disorder characterized by the inappropriate accumulation of unesterified cholesterol in lysosomes [1]. NP-C patients show various defects including hepatosplenomegaly, ataxia, dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5dd2e2251f014cf385557140c4db3e

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Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans

Autor: Yung S Lie, Quee-Lim Ch'ng, Lisa Williams, Jennifer Whangbo, Mary Sym, Cynthia Kenyon

Publikováno v: Europe PubMed Central
Scopus-Elsevier

In C. elegans, cells of the QL and QR neuroblast lineages migrate with left-right asymmetry; QL and its descendants migrate posteriorly whereas QR and its descendants migrate anteriorly. One key step in generating this asymmetry is the expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96bc076113e5b63c0fe2c44c6bdb771
http://europepmc.org/abstract/med/12930745

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