Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Mary Sundsmo"'
1
Characterization of the human α-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphisms1
Autor: Eliezer Masliah, Kenji Uéda, Tsunao Saitoh, Robert Katzman, Makoto Hashimoto, Chris Conrad, Leigh J. Hsu, Leon J. Thal, Mary Sundsmo, Yu Xia, Makoto Yoshimoto, Xiaohua Chen, Seigo Tanaka
Publikováno v: Journal of Alzheimer's Disease. 3:485-494
The human NACP/alpha-synuclein gene has been cloned. This gene consists of 6 exons ranging in size from 42 to 1110 bp. The translation start codon ATG is encoded by exon 2 and the stop codon TAA is encoded by exon 6. The non-Abeta component of Alzhei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c781ef713061f7f88785b0a855176a78
https://doi.org/10.3233/jad-2001-3508
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2
Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro
Autor: Eliezer Masliah, Leigh J. Hsu, Mary Sundsmo, Yu Xia, Ayako Takeda, Makoto Hashimoto, Abbyann Sisk
Publikováno v: NeuroReport. 10:717-721
The precursor of non-amyloid beta protein component of Alzheimer's disease amyloid (NACP/alpha-synuclein), found in Lewy bodies of Parkinson's disease (PD), is a presynaptic protein genetically linked to some familial types PD. Mechanisms of abnormal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16f3a1dadb15c10756c642dfba78a72
https://doi.org/10.1097/00001756-199903170-00011
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3
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease
Autor: Eliezer Masliah, Kunihiro Ueda, John Q. Trojanowski, Robert Katzman, R. G. Thomas, Yu Xia, Naomi Matoh, David E. Kang, Mary Sundsmo, Leon J. Thal, Xu Chen, Tsunao Saitoh, Seigo Tanaka
Publikováno v: Neurology. 50:1556-1562
To examine the genetic association of CYP2D6 locus with Lewy body variant (LBV) and Parkinson's disease (PD).Allelic association was studied in patients with pure AD, LBV, and PD by using the CYP2D microsatellite, the (dG-dT)n dinucleotide repeat (n=
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01ddc69cf0e7b4a1507164eba882d72
https://doi.org/10.1212/wnl.50.6.1556
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4
Defective neurite extension is caused by a mutation in amyloid ?/A4 (A?) protein precursor found in Familial Alzheimer's Disease
Autor: Deborah A. C. Otero, Jean-Marc Roch, Sangram S. Sisodia, Mary Sundsmo, Hai Ling Li, Tsunao Saitoh, Ronald G. Thomas
Publikováno v: Journal of Neurobiology. 32:469-480
Clonal central nervous system neuronal cells, B103, do not synthesize detectable endogenous APP or APLP. B103 cells transfected with both wild-type (B103/APP) and mutant APP construct (B103/APP delta NL) secreted comparable amounts of soluble forms o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::067d7b04e48fdf2b5e81782a789a6dc5
https://doi.org/10.1002/(sici)1097-4695(199705)32:5<469::aid-neu3>3.0.co
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5
Genetic studies in Alzheimer's disease with an NACP/?-synuclein polymorphism
Autor: Robert Katzman, Mary Sundsmo, Larry H. Yamaoka, Ronald G. Thomas, H.A.Rohan de Silva, Margaret A. Pericak-Vance, J. B. Rimmler, Tsunao Saitoh, B.L. Rosi, Akihiko Iwai, Leon J. Thal, Xiaohua Chen, Ethan Gregory, Eliezer Masliah, Lawrence A. Hansen, C. Richard Hofstetter, Yu Xia, Richard DeTeresa, Allen D. Roses
Publikováno v: Annals of Neurology. 40:207-215
The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5b05338003ddafadb1bc90313f81d1
https://doi.org/10.1002/ana.410400212
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6
Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease
Autor: Margaret Mallory, Tsunao Saitoh, D. Iimoto, Eliezer Masliah, Richard DeTeresa, Mary Sundsmo, A. Sobel, N. Mori, Lee-Way Jin
Publikováno v: Neurobiology of Aging. 17:331-341
Stathmin (p19), a 19-kDa cytosolic phosphoprotein, plays a key role in converting extracellular signals into intracellular biochemical changes. Antibodies and cDNA specific for stathmin were used to study its levels and localization in normal and Alz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437ff44bf826c602b019df78f265c918
https://doi.org/10.1016/0197-4580(96)00021-8
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7
The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease
Autor: Richard DeTeresa, Mary Sundsmo, Eliezer Masliah, Tsunao Saitoh, Margaret Mallory, David P. Salmon, Akihiko Iwai
Publikováno v: Brain Research. 720:230-234
NACP, the precursor of non-A beta component of Alzheimer's disease (AD) amyloid (NAC), is a synaptic protein that could potentially be involved in AD. We studied, by dot-blot, NACP levels in the frontal cortex of AD cases staged according to severity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d1ffac5b45e6e938c4fb4cf5a98099
https://doi.org/10.1016/0006-8993(96)00014-5
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8
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor
Autor: Eliezer Masliah, Anne-Catherine Roch-Levecq, Tsuano Saitoh, Isaac Veinbergs, Deborah A. C. Otero, Mary Sundsmo, Jean-Marc Roch
Publikováno v: Proceedings of the National Academy of Sciences. 91:7450-7454
The secreted form (sAPP) of the Alzheimer amyloid beta/A4 protein precursor (APP) has been shown to be involved in the in vitro regulation of fibroblast growth and neurite extension from neuronal cells. The active site of sAPP responsible for these f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d899aad9b524349d1591780591074a0
https://doi.org/10.1073/pnas.91.16.7450
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9
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth
Autor: Tsunao Saitoh, Dennis C. Otero, Jean-Marc Roch, H. Ninomiya, Mary Sundsmo
Publikováno v: The Journal of Cell Biology
The growth of A-1 fibroblasts depends on exogenous amyloid beta/A4 protein precursor (APP), providing a simple bioassay to study the function of APP. Our preliminary study, testing the activity of a series of fragments derived from the secreted form
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f501a1bd8bb8302cc5a1778b8d26323e
https://doi.org/10.1083/jcb.121.4.879
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10
Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor
Autor: Dennis C. Otero, Tsunao Saitoh, Jean-Marc Roch, I. P. Shapiro, L. M. Refolo, N. K. Robakis, Mary Sundsmo
Publikováno v: Journal of Biological Chemistry. 267:2214-2221
The secreted form of Alzheimer amyloid beta/A4 protein precursor (APP) has been shown to be involved in cell growth regulation (Saitoh, T., Sundsmo, M., Roch, J.-M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., and Schenk, D.B. (1989) Cell 58,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d18635127e89caa21d838e3e0da0edd9
https://doi.org/10.1016/s0021-9258(18)45864-4
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