Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Mary Shago"'
Autor:
Samuele Renzi, Fatimah Algawahmed, Scott Davidson, Karin P. S. Langenberg, Fabio Fuligni, Salah Ali, Nathaniel Anderson, Ledia Brunga, Jack Bartram, Mohamed Abdelhaleem, Ahmed Naqvi, Kassa Beimnet, Andre Schuh, Anne Tierens, David Malkin, Adam Shlien, Mary Shago, Anita Villani
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 5946-5952 (2023)
ETV6-ABL1 gene fusion is a rare genetic rearrangement in a variety of malignancies, including myeloproliferative neoplasms (MPN), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). Here, we report the case of a 16-year-old male dia
Externí odkaz:
https://doaj.org/article/a592fb16ae0b494781fe3064b7d6424d
Autor:
Mary E. McQuaid, Kashif Ahmed, Stephanie Tran, Justine Rousseau, Ranad Shaheen, Kristin D. Kernohan, Kyoko E. Yuki, Prerna Grover, Ema S. Dreseris, Sameen Ahmed, Lucie Dupuis, Jennifer Stimec, Mary Shago, Zuhair N. Al-Hassnan, Roch Tremblay, Philipp G. Maass, Michael D. Wilson, Eyal Grunebaum, Kym M. Boycott, François-Michel Boisvert, Sateesh Maddirevula, Eissa A. Faqeih, Fahad Almanjomi, Zaheer Ullah Khan, Fowzan S. Alkuraya, Philippe M. Campeau, Peter Kannu, Eric I. Campos, Hugo Wurtele
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
The eukaryotic CDC45/MCM2-7/GINS (CMG) helicase unwinds the DNA double helix during DNA replication. The GINS subcomplex is required for helicase activity and is, therefore, essential for DNA replication and cell viability. Here, we report the identi
Externí odkaz:
https://doaj.org/article/3826d777770e43a3ada9bdd9c34ba315
Autor:
Ana S. Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E. Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K. Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R. Boué, Jonathan L. Finlay, Scott L. Coven, Inmaculada de Prada, Marta Perez-Somarriba, Claudia C. Faria, Michael A. Grotzer, Elisabeth Rushing, David Sumerauer, Josef Zamecnik, Lenka Krskova, Miguel Garcia Ariza, Ofelia Cruz, Andres Morales La Madrid, Palma Solano, Keita Terashima, Yoshiko Nakano, Koichi Ichimura, Motoo Nagane, Hiroaki Sakamoto, Maria Joao Gil-da-Costa, Roberto Silva, Donna L. Johnston, Jean Michaud, Bev Wilson, Frank K. H. van Landeghem, Angelica Oviedo, P. Daniel McNeely, Bruce Crooks, Iris Fried, Nataliya Zhukova, Jordan R. Hansford, Amulya Nageswararao, Livia Garzia, Mary Shago, Michael Brudno, Meredith S. Irwin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet, Michael D. Taylor, Uri Tabori, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.
Externí odkaz:
https://doaj.org/article/1dd77b35b12f4fbfa3be4dbd3feb1c2b
Autor:
Yiqiao Wang, Andre Le, Dina El Demellawy, Mary Shago, Michael Odell, Stephanie Johnson-Obaseki
Publikováno v:
Journal of Otolaryngology - Head and Neck Surgery, Vol 48, Iss 1, Pp 1-7 (2019)
Abstract Background Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Divided into non- and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly,
Externí odkaz:
https://doaj.org/article/dd4fb83c6d6d4b18b5cf1a932853c87b
Autor:
Nicolas Waespe, Santhosh Dhanraj, Manju Wahala, Elena Tsangaris, Tom Enbar, Bozana Zlateska, Hongbing Li, Robert J. Klaassen, Conrad V. Fernandez, Geoff D. E. Cuvelier, John K. Wu, Yves D. Pastore, Mariana Silva, Jeffrey H. Lipton, Joseé Brossard, Bruno Michon, Sharon Abish, MacGregor Steele, Roona Sinha, Mark J. Belletrutti, Vicky R. Breakey, Lawrence Jardine, Lisa Goodyear, Liat Kofler, Michaela Cada, Lillian Sung, Mary Shago, Stephen W. Scherer, Yigal Dror
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-8 (2017)
Blood disorders: impact of genomic structural variation Copy number variation in patients with inherited bone marrow failure syndromes (IBMFSs) is associated with more severe clinical symptoms. In addition to persistently low levels of red blood cell
Externí odkaz:
https://doaj.org/article/fab055366f7246f79c31483ee2eaa142
Autor:
Michaela Cada, Catherin I. Segbefia, Robert Klaassen, Conrad V. Fernandez, Rochelle A. Yanofsky, John Wu, Yves Pastore, Mariana Silva, Jeffrey H. Lipton, Josee Brossard, Bruno Michon, Sharon Abish, MacGregor Steele, Roona Sinha, Mark Belletrutti, Vicky Breakey, Lawrence Jardine, Lisa Goodyear, Lillian Sung, Mary Shago, Joseph Beyene, Preeti Sharma, Bozana Zlateska, Yigal Dror
Publikováno v:
Haematologica, Vol 100, Iss 5 (2015)
Inherited bone marrow failure syndromes are a group of rare, heterogeneous genetic disorders with a risk of clonal and malignant myeloid transformation including clonal marrow cytogenetic abnormalities, myelodysplastic syndrome and acute myeloid leuk
Externí odkaz:
https://doaj.org/article/f54fe41b7fba481f91c0c91d5b820ffa
Autor:
Samuel Levy, Granger Sutton, Pauline C Ng, Lars Feuk, Aaron L Halpern, Brian P Walenz, Nelson Axelrod, Jiaqi Huang, Ewen F Kirkness, Gennady Denisov, Yuan Lin, Jeffrey R MacDonald, Andy Wing Chun Pang, Mary Shago, Timothy B Stockwell, Alexia Tsiamouri, Vineet Bafna, Vikas Bansal, Saul A Kravitz, Dana A Busam, Karen Y Beeson, Tina C McIntosh, Karin A Remington, Josep F Abril, John Gill, Jon Borman, Yu-Hui Rogers, Marvin E Frazier, Stephen W Scherer, Robert L Strausberg, J Craig Venter
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e254 (2007)
Presented here is a genome sequence of an individual human. It was produced from approximately 32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled into 4,528 scaffolds, comprising 2,810 million bases (Mb) of contiguo
Externí odkaz:
https://doaj.org/article/1ebc1b9d3b354a3c848c72f1b19274b6
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
Autor:
Anita Villani, Scott Davidson, Nisha Kanwar, Winnie W. Lo, Yisu Li, Sarah Cohen-Gogo, Fabio Fuligni, Lisa-Monique Edward, Nicholas Light, Mehdi Layeghifard, Ricardo Harripaul, Larissa Waldman, Bailey Gallinger, Federico Comitani, Ledia Brunga, Reid Hayes, Nathaniel D. Anderson, Arun K. Ramani, Kyoko E. Yuki, Sasha Blay, Brittney Johnstone, Cara Inglese, Rawan Hammad, Catherine Goudie, Andrew Shuen, Jonathan D. Wasserman, Rosemarie E. Venier, Marianne Eliou, Miranda Lorenti, Carol Ann Ryan, Michael Braga, Meagan Gloven-Brown, Jianan Han, Maria Montero, Famida Spatare, James A. Whitlock, Stephen W. Scherer, Kathy Chun, Martin J. Somerville, Cynthia Hawkins, Mohamed Abdelhaleem, Vijay Ramaswamy, Gino R. Somers, Lianna Kyriakopoulou, Johann Hitzler, Mary Shago, Daniel A. Morgenstern, Uri Tabori, Stephen Meyn, Meredith S. Irwin, David Malkin, Adam Shlien
Publikováno v:
Nature Cancer. 4:203-221
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300 mostly previously treated children and adolescents/young adults with cancer of poor prognosis or with r
Autor:
Alaa Koleilat, James B. Smadbeck, Cinthya J. Zepeda‐Mendoza, Cynthia M. Williamson, Beth A. Pitel, Crystal L. Golden, Xinjie Xu, Patricia T. Greipp, Rhett P. Ketterling, Nicole L. Hoppman, Jess F. Peterson, Christine J. Harrison, Yassmine M. N. Akkari, Karen D. Tsuchiya, Mary Shago, Linda B. Baughn
Publikováno v:
Genes, Chromosomes and Cancer. 61:710-719
Acute lymphoblastic leukemia (B-ALL) with intrachromosomal amplification of chromosome 21 (iAMP21-ALL) represents a recurrent high-risk cytogenetic abnormality and accurate identification is critical for appropriate clinical management. Identificatio
Autor:
Zhenhua Li, Ti-Cheng Chang, Jacob J Junco, Meenakshi Devidas, Yizhen Li, Wenjian Yang, Xin Huang, Dale J Hedges, Zhongshan Cheng, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie M Gastier-Foster, Brent L. Wood, Michael J. Borowitz, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Eleanor Feingold, Tracie C. Rosser, Stephanie L. Sherman, Mignon L. Loh, Charles G. Mullighan, Jiyang Yu, Gang Wu, Philip J Lupo, Karen R Rabin, Jun J. Yang
Publikováno v:
Blood.
Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic leukemia (ALL) during childhood and results in distinctive leukemia biology.