Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mary S. Rosendahl"'
Autor:
Eliana B Gomez, Kevin Ebata, Hetal S Randeria, Mary S Rosendahl, Ernst Peder Cedervall, Tony H Morales, Lauren M Hanson, Nicholas E Brown, Xueqian Gong, Jennifer Rachelle Stephens, Wenjuan Wu, Isabel Lippincott, Karin S. Ku, Richard A Walgren, Paolo B Abada, Joshua A Ballard, Charles K Allerston, Barbara J Brandhuber
Publikováno v:
Blood.
Bruton tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a major therapeutic target for B-cell driven malignancies. However, approved covalent BTK inhibitors (cBTKi) are associated with treatment limitations due to off-target side effects, sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2333a010be3bb4fc08946997fe84cf
https://doi.org/10.1182/blood.2022018674
https://doi.org/10.1182/blood.2022018674
Publikováno v:
The Protein Journal. 39:160-173
Previously we reported that site-specific modification of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) A3C analog with polyethylene glycol (PEG) dramatically improved the pharmacokinetic properties of the protein in rats. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702e948f61c5439a879e090e1b2f888
https://doi.org/10.1007/s10930-020-09894-0
https://doi.org/10.1007/s10930-020-09894-0
Publikováno v:
Blood. 136:32-33
Introduction: Bruton's Tyrosine Kinase (BTK) is an essential component of normal and malignant B-cell receptor signaling. Covalent BTK inhibitors have transformed the treatment of B-cell malignancies. Despite the marked efficacy of covalent BTKi, tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734e28988bcc671a76166785f4be2f75
https://doi.org/10.1182/blood-2020-140581
https://doi.org/10.1182/blood-2020-140581
Publikováno v:
BioProcess international. 3(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::921711fa19d73e7db742ff60b4c2f374
https://pubmed.ncbi.nlm.nih.gov/29899681
https://pubmed.ncbi.nlm.nih.gov/29899681
Autor:
Amber Haynes Fradkin, Stephen P. Eisenberg, Mary S. Rosendahl, Carl S. Boand, Theodore W. Randolph
Publikováno v:
Biotechnology Progress. 26:743-749
We expressed recombinant murine growth hormone (rmGH) in E. coli as a cost-effective way to produce large quantities (gram scale) of the protein for use in murine studies of immunogenicity to therapeutic proteins. High hydrostatic pressure was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f4e76dda4f004432ef4ea94eb033e7
https://doi.org/10.1002/btpr.393
https://doi.org/10.1002/btpr.393
Publikováno v:
Current Pharmaceutical Biotechnology. 10:447-455
Non-denaturing pressures of around 2000 bar are effective for eliminating and refolding protein aggregates and may be applicable in various phases of protein manufacturing to decrease aggregate levels in products and improve process yields. Lower agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1270eb54bc2f002070ec756716ff56
https://doi.org/10.2174/138920109788488914
https://doi.org/10.2174/138920109788488914
Autor:
Christine M. Fam, Ji I Lee, Mary S. Rosendahl, Daniel H. Doherty, George N. Cox, Stacie J. Bell, Elizabeth A. Chlipala, Sharon J. Carlson
Publikováno v:
Bioconjugate Chemistry. 19:299-305
Recombinant interferon alpha-2 (IFN-alpha2) has proven useful for treating a variety of human cancers and viral diseases. IFN-alpha2 has a short circulating half-life in vivo, which necessitates daily or thrice weekly administration to patients. It i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5934f660ce29217defa4f1a64fcc1a8d
https://doi.org/10.1021/bc070131q
https://doi.org/10.1021/bc070131q
Autor:
Elizabeth A. Chlipala, Sharon J. Carlson, Mary S. Rosendahl, Darin J. Smith, George N. Cox, Daniel H. Doherty
Publikováno v:
Endocrinology. 148:1590-1597
Recombinant human Growth Hormone (GH) is used to treat growth hormone deficiency in children and adults, and wasting in AIDS patients. GH has a circulating half-life of only a few hours in humans and must be administered to patients by daily injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c1d9f464d3a5d5f7940d07c353d894
https://doi.org/10.1210/en.2006-1170
https://doi.org/10.1210/en.2006-1170
Autor:
Elizabeth A. Chlipala, Kurt Christensen, Mary S. Rosendahl, Daniel H. Doherty, Dean P. Edwards, George N. Cox, Dana L. Long, Darin J. Smith, Stephen P. Eisenberg
Publikováno v:
Experimental Hematology. 34:697-704
Objective Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b274e3397eaaa9f4a3ac06ffaf51fc8e
https://doi.org/10.1016/j.exphem.2006.02.011
https://doi.org/10.1016/j.exphem.2006.02.011
Autor:
George N. Cox, Christine M. Fam, Mary S. Rosendahl, Elizabeth A. Chlipala, Sharon J. Carlson, Stephen P. Eisenberg
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 34(10)
Interferon gamma (IFN-γ) is a 28 kDa homodimeric cytokine that exhibits potent immunomodulatory, anti-proliferative, and antiviral properties. The protein is used to treat chronic granulomatous disease and malignant osteopetrosis, and it is under in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03351d8e28c25d1f89bf6877431ffbe7
https://pubmed.ncbi.nlm.nih.gov/24841172
https://pubmed.ncbi.nlm.nih.gov/24841172