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Autor:
Mary S. Rosendahal, Lippincott Isabel, Barb J. Brandhuber, Eliana B. Gomez, Andrews Steven W, Stephen M. Rothenberg
Publikováno v:
Blood. 134:4644-4644
Introduction: Bruton's Tyrosine Kinase (BTK) is an essential component of normal and malignant B-cell receptor signaling. Covalent BTK inhibitors have transformed the treatment of B-cell malignancies but are limited by off-target toxicity and acquire