Výsledky vyhledávání - "Mary S. Rackley"

Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression

Autor: Terrence X. O'Brien, Brett S. Harris, D. Woodrow Benson, Robert G. Gourdie, Mary S. Rackley, Laura Spruill, Angela M. Edmonson

Publikováno v: Developmental Dynamics. 235:38-49

Nkx2-5 gene mutations cause cardiac abnormalities, including deficits of function in the atrioventricular conduction system (AVCS). In the chick, Nkx2-5 is elevated in Purkinje fiber AVCS cells relative to working cardiomyocytes. Here, we show that N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42c5bd25c1b3ca89a270a5f023c4704
https://doi.org/10.1002/dvdy.20580

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Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC

Autor: Patrick Y. Jay, Seigo Izumo, Terrence X. O'Brien, Robert G. Gourdie, Brett S. Harris, Mary S. Rackley

Publikováno v: The Anatomical Record. :1036-1045

The development of the complex network of specialized cells that form the atrioventricular conduction system (AVCS) during cardiac morphogenesis occurs by progressive recruitment within a multipotent cardiomyogenic lineage. Understanding the molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f9e2985b378be0e8427c8f132a6f52e
https://doi.org/10.1002/ar.a.20101

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Remodeling of the peripheral cardiac conduction system in response to pressure overload

Autor: Harinath Kasiganesan, Brett S. Harris, Lucile Miquerol, Daniel Gros, Mary S. Rackley, Terrence X. O'Brien, Dimitri Scholz, Rupak Mukherjee, Nicole Haghshenas, Catalin F. Baicu

Publikováno v: AJP-Heart and Circulatory Physiology
AJP-Heart and Circulatory Physiology, American Physiological Society, 2012, 302 (8), pp.H1712-25. ⟨10.1152/ajpheart.00621.2011⟩
AJP-Heart and Circulatory Physiology, 2012, 302 (8), pp.H1712-25. ⟨10.1152/ajpheart.00621.2011⟩

How chronic pressure overload affects the Purkinje fibers of the ventricular peripheral conduction system (PCS) is not known. Here, we used a connexin (Cx)40 knockout/enhanced green fluorescent protein knockin transgenic mouse model to specifically l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512e6c9e7077ea2ed3eef18c65ec2c01
https://hal.archives-ouvertes.fr/hal-00839105

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Abstract 1404: How Peripheral Cardiac Conduction Cells Adapt to Pressure Overload

Autor: Brett S Harris, Dimitri Scholz, Catalin F Baicu, Patrick Y Jay, Mary S Rackley, Terrence X O’Brien

Publikováno v: Circulation. 116

The ventricular peripheral conduction system (PCS) is composed of unique cardiomyocytes responsible in health for the coordinated contraction of every working cardiomyoctye. Although isolated PCS cells have been studied extensively, in vivo study has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f5cf409d8d4e52153cbb61884a01fd6
https://doi.org/10.1161/circ.116.suppl_16.ii_288-c

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Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor

Autor: Seigo Izumo, Tim C. McQuinn, Donald R. Menick, Hideko Kasahara, Joachim G. Müller, Angela M. Edmonson, Jerry T. Thompson, Mary S. Rackley, Terrence X. O'Brien

Publikováno v: Journal of molecular and cellular cardiology. 34(7)

J. G. Muller, J. T. Thompson, A. M. Edmonson, M. S. Rackley, H. Kasahara, S. Izumo, T. C. Mcquinn, D. R. Menick and T. X. O'Brien. Differential Regulation of the Cardiac Sodium Calcium Exchanger Promoter in Adult and Neonatal Cardiomyocytes by Nkx2.5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba243b43b63838c3452e925220617bc
https://pubmed.ncbi.nlm.nih.gov/12099720

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F1-ATP synthase beta-subunit and cytochrome c transcriptional regulation in right ventricular hemodynamic overload and hypertrophically stimulated cardiocytes

Autor: Gregg T. Schuyler, Jerry T. Thompson, Terrence X. O'Brien, Mary S. Rackley

Publikováno v: Journal of molecular and cellular cardiology. 31(1)

Cardiac hypertrophic growth secondary to hemodynamic pressure overload causes changes in energy requirements that may involve the transcriptional upregulation of oxidative phosphorylation genes. Therefore, two representative nuclear-encoded genes, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4248f7a1e4a6e23d9b740ed62eebcf1
https://pubmed.ncbi.nlm.nih.gov/10072725

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Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload

Autor: Jerry T. Thompson, Mary S. Rackley, Terrence X. O'Brien

Publikováno v: The American journal of physiology. 274(5)

The recent characterization of the cardiac-specific homeobox gene Nkx2–5 (or CSX) and its detection in normal adult heart tissue raises the possibility of a role in adult hypertrophy. Using pressure overload as a primary stimulus, we used a feline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eca6f1f35b209ff1f8a89fe674d4bb
https://pubmed.ncbi.nlm.nih.gov/9612365

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