Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Mary S Leffell"'
Autor:
Andrea A. Zachary, Mary S Leffell
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression. Mismatches are attended by more frequent rejection ep
Externí odkaz:
https://doaj.org/article/298f735b2bfe4633a26ddabd54a1c83f
Autor:
Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy
Publikováno v:
PLoS Genetics, Vol 3, Iss 6, p e103 (2007)
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the pro
Externí odkaz:
https://doaj.org/article/b95e2c17c8d74b7e8a44a4306cbe19db
Autor:
Robert A. Montgomery, Michelle A. Evans, David F. Pinelli, Ashley Vo, Erik N. Chatroop, Stanley C. Jordan, John J. Friedewald, Mary S. Leffell, David W. Gjertson, Anat R. Tambur, Andrea A. Zachary
Publikováno v:
American Journal of Transplantation. 19:381-390
Currently, the ability to predict or monitor the efficacy of HLA antibody-removal therapies is deficient. We previously reported that titration studies are a consistent and accurate means of assessing antibody strength. To test whether titration stud
Autor:
Annette M. Jackson, Mary S. Leffell, Duska Dragun, Robert A. Montgomery, Serena M. Bagnasco, Edward S. Kraus, Andrea A. Zachary, Mary Carmelle Philogene
Publikováno v:
Transplantation
Background This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). Methods Non-HLA antibo
Publikováno v:
Nature reviews. Nephrology. 14(9)
The human major histocompatibility complex is a family of genes that encodes HLAs, which have a crucial role in defence against foreign pathogens and immune surveillance of tumours. In the context of transplantation, HLA molecules are polymorphic ant
Autor:
Annette M. Jackson, Serena M. Bagnasco, Mary S. Leffell, Robert A. Montgomery, Edward S. Kraus, Bonnie E. Lonze, Sheng Zhou, Mary Carmelle Philogene, Sami Alasfar, Andrea A. Zachary
Publikováno v:
Human immunology. 79(4)
Retrospective studies of angiotensin II type 1 receptor antibodies (AT1R-Ab) and anti-endothelial cell antibodies (AECA) have linked these antibodies to allograft injury. Because rising healthcare costs dictate judicious use of laboratory testing, we
Publikováno v:
Transplantation
Background Information about differences in immunogenicity of various HLA antigens may help guide donor selection and identify mismatches to avoid for patients likely to need retransplantation. To date, antibody responses to a wide array of individua
Autor:
Andrea A. Zachary, Mary S. Leffell
Publikováno v:
Immunological Reviews
Desensitization protocols are being used worldwide to enable kidney transplantation across immunologic barriers, i.e. antibody to donor HLA or ABO antigens, which were once thought to be absolute contraindications to transplantation. Desensitization
Autor:
Christopher D. Blosser, Sommer E. Gentry, Dorry L. Segev, Francis L. Delmonico, R. Leishman, Mary S. Leffell, Alan B. Leichtman, Sandy Feng, Greg Knoll, Lee Ann Baxter-Lowe, Michael A. Rees, Elaine F. Reed, David Serur, Peter Nickerson, James R. Rodrigue, Stefan G. Tullius, D. A. Mast, Edward Y. Zavala, Marc L. Melcher
Publikováno v:
American Journal of Transplantation. 13:851-860
While kidney paired donation (KPD) enables the utilization of living donor kidneys from healthy and willing donors incompatible with their intended recipients, the strategy poses complex challenges that have limited its adoption in United States and
Autor:
Mary S. Leffell, Richard J. Jones, Robert A. Brodsky, Douglas E. Gladstone, Andrea A. Zachary, Leo Luznik, Ephraim J. Fuchs, Yvette L. Kasamon, Karen E. King Karen E. King
Publikováno v:
Biology of Blood and Marrow Transplantation. 19:647-652
The presence of donor human leukocyte antigen (HLA)-specific antibodies (DSA) increases engraftment failure risk in partially HLA-mismatched, or HLA-haploidentical, allogeneic marrow (alloBMT) transplantation. As pre-existing sensitization to HLA ant