Výsledky vyhledávání - "Mary Rose Schwarb"

Allele-Specific Binding of Airway Nuclear Extracts to Polymorphic β2-Adrenergic Receptor 5′ Sequence

Autor: Clare B. Glinka, Mary Rose Schwarb, Alfredo Panebra, Stephen B. Liggett

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 36:654-660

Like other intronless G protein-coupled receptor genes, the beta(2)-adrenergic receptor (beta(2)AR) has minimal genetic space for population variability, and has attained such via multiple coding and noncoding polymorphisms. Yet most clinical studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab01039382eaf6395d9aea08424c85ce
https://doi.org/10.1165/rcmb.2006-0394oc

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Airway smooth muscle prostaglandin-EP1 receptors directly modulate 2-adrenergic receptors within a unique heterodimeric complex

Autor: Khalid F. Almoosa, Mary Rose Schwarb, Kathryn A. Mihlbachler, Kersten M. Small, Dennis W. McGraw, Stephen B. Liggett, Fahema F. Rahman

Publikováno v: Journal of Clinical Investigation. 116:1400-1409

Multiple and paradoxical effects of airway smooth muscle (ASM) 7-transmembrane-spanning receptors activated during asthma, or by treatment with bronchodilators such as beta(2)-adrenergic receptor (beta(2)AR) agonists, indicate extensive receptor cros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5f6ee145f23338c5472650b5552cbd
https://doi.org/10.1172/jci25840

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α2A- and α2C-Adrenergic Receptors Form Homo- and Heterodimers: The Heterodimeric State Impairs Agonist-Promoted GRK Phosphorylation and β-Arrestin Recruitment

Autor: Carrie A. Seman, Stephen B. Liggett, Mary Rose Schwarb, Kari M. Brown, Kersten M. Small, Cheryl T. Theiss, Clare B. Glinka

Publikováno v: Biochemistry. 45:4760-4767

Dimerization of seven transmembrane-spanning receptors diversifies their pharmacologic and physiologic properties. The alpha(2)-adrenergic receptor (alpha(2)AR) subtypes A and C are both expressed on presynaptic nerves and act to inhibit norepinephri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaf9a0f77fd4728f16621b507da0895
https://doi.org/10.1021/bi052074z

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Variable Length Poly-C Tract Polymorphisms of the β2-adrenergic Receptor 3′UTR Alter Expression and Agonist Regulation

Autor: Stephen B. Liggett, Steven M. Swift, Scott T. Weiss, Gregory A. Hawkins, Alfredo Panebra, Mary Rose Schwarb, Eugene R. Bleecker

β2-Adrenergic receptors (β2-AR) expressed on airway epithelial and smooth muscle cells regulate mucociliary clearance and relaxation and are the targets for β-agonists in the treatment of obstructive lung disease. However, the clinical responses d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df789bde8499934fc2b524e012c48574
https://europepmc.org/articles/PMC6092935/

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Heterogeneity of Transcription Factor Expression and Regulation in Human Airway Epithelial and Smooth Muscle Cells

Autor: Stephen B. Liggett, Alfredo Panebra, Mary Rose Schwarb, Clare B. Glinka

Transcription factors represent a major mechanism by which cells establish basal and conditional expression of proteins, the latter potentially being adaptive or maladaptive in disease. The complement of transcription factors in two major structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71eb3dfb470abc028793fe142f4ffce0
https://europepmc.org/articles/PMC6092943/

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