Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Mary R. Avarbock"'
Autor:
Eoin C. Whelan, Fan Yang, Mary R. Avarbock, Megan C. Sullivan, Daniel P. Beiting, Ralph L. Brinster
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular biopsy prior
Externí odkaz:
https://doaj.org/article/92e0bc0a69a34c57a84f10e28e68e73c
Publikováno v:
Stem Cells International, Vol 2016 (2016)
The chemokine (C-X-C) receptor type 4 (CXCR4) is an early marker of primordial germ cells (PGCs) essential for their migration and colonization of the gonads. In spermatogonial stem cells (SSCs), the expression of CXCR4 is promoted by the self-renewa
Externí odkaz:
https://doaj.org/article/2c8d9dd98f7a4f3ca1376586bc876c1f
Autor:
John W. Tobias, Mary R. Avarbock, Nilam Sinha, Eoin C Whelan, Ralph L. Brinster, Darko Stefanovski
Publikováno v:
Biology of Reproduction. 105:503-518
Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it operates remains largely unknown. We developed a germ cell culture assay system to study genes involved in spermatogonial differentiation triggered by RA. Stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479efbd2c5d4d942519cdd7343468326
https://doi.org/10.1093/biolre/ioab093
https://doi.org/10.1093/biolre/ioab093
Autor:
Eoin C. Whelan, Fan Yang, Mary R. Avarbock, Megan C. Sullivan, Daniel P. Beiting, Ralph L. Brinster
Publikováno v:
PLoS biology. 20(5)
Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular biopsy prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30d4047317552614162499bd62824f3
https://pubmed.ncbi.nlm.nih.gov/35536782
https://pubmed.ncbi.nlm.nih.gov/35536782
Autor:
Bingquan Deng, Ralph L. Brinster, Fan Yang, Jiachen Sun, Shu Wang, Eoin C Whelan, Xin Wu, Xuebing Guan, Mary R. Avarbock
Publikováno v:
Cell Proliferation
Objectives Fibroblast growth factor 9 (FGF9) is expressed by somatic cells in the seminiferous tubules, yet little information exists about its role in regulating spermatogonial stem cells (SSCs). Materials and Methods Fgf9 overexpression lentivirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1c1ecf383acc4b0c07802cdce612f8
https://doi.org/10.1111/cpr.12933
https://doi.org/10.1111/cpr.12933
Publikováno v:
Biology of Reproduction. 85:1114-1123
Insight regarding mechanisms controlling gene expression in the spermatogonial stem cell (SSC) will improve our understanding of the processes regulating spermatogenesis and aid in treating problems associated with male infertility. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340a0d80afcd1997b89fcb480fcd6fb6
https://doi.org/10.1095/biolreprod.111.091793
https://doi.org/10.1095/biolreprod.111.091793
Autor:
Jonathan A. Schmidt, Xin Wu, Marisa S. Bartolomei, Mary R. Avarbock, John W. Tobias, Zhiyv Niu, Hiroshi Kubota, Lara K. Abramowitz, Ralph L. Brinster
Publikováno v:
Biology of Reproduction. 84:698-706
The development of techniques to maintain the spermatogonial stem cell (SSC) in vivo and in vitro for extended periods essentially allows for the indefinite continuation of an individual germline. Recent evidence indicates that the aging of male repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c66452897e229252746c377c514df9c
https://doi.org/10.1095/biolreprod.110.088229
https://doi.org/10.1095/biolreprod.110.088229
Publikováno v:
Biology of Reproduction. 83:427-433
Homeostasis of many tissues is maintained by self-renewal and differentiation of stem cells. Spermatogenesis is one such system relying on the activity of spermatogonial stem cells (SSCs). Several key regulators of SSC self-renewal have been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83b3ad73bb2c3dd8b069858193b56d5
https://doi.org/10.1095/biolreprod.109.083352
https://doi.org/10.1095/biolreprod.109.083352
Autor:
Mary R. Avarbock, Jon M. Oatley, Amy V. Kaucher, Melissa J. Oatley, Ralph L. Brinster, Xin Wu
Publikováno v:
Biology of Reproduction. 82:1103-1111
Continual spermatogenesis relies on a pool of spermatogonial stem cells (SSCs) that possess the capacity for self-renewal and differentiation. Maintenance of this pool depends on survival of SSCs throughout the lifetime of a male. Response to extrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152f8f5b62e63dfe892a77a7ff6243ab
https://doi.org/10.1095/biolreprod.109.083097
https://doi.org/10.1095/biolreprod.109.083097
Autor:
Xin Wu, Claire A. Carlson, Jonathan A. Schmidt, John W. Tobias, Jill P. Ginsberg, Thomas F. Kolon, Ralph L. Brinster, Mary R. Avarbock
Publikováno v:
Proceedings of the National Academy of Sciences. 106:21672-21677
In the human testis, beginning at ≈2 months of age, gonocytes are replaced by adult dark (Ad) and pale (Ap) spermatogonia that make up the spermatogonial stem cell (SSC) pool. In mice, the SSC pool arises from gonocytes ≈6 days after birth. Durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59196863007ae4933d7a050eb953654
https://doi.org/10.1073/pnas.0912432106
https://doi.org/10.1073/pnas.0912432106