Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Mary R Loeken"'
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29379 (2011)
Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac neural crest defects in Pax3-mutant m
Externí odkaz:
https://doaj.org/article/6d8d70683a4a4320a29ff60b9daa1fa8
Autor:
Jin Hyuk Jung, Mary R. Loeken
Publikováno v:
Antioxidants, Vol 10, Iss 1156, p 1156 (2021)
Antioxidants
Volume 10
Issue 8
Antioxidants
Volume 10
Issue 8
The high KM glucose transporter, GLUT2 (SLC2A2), is expressed by embryos and causes high rates of glucose transport during maternal hyperglycemic episodes in diabetic pregnancies and causes congenital malformations (diabetic embryopathy). GLUT2 is al
Publikováno v:
Diabetic Medicine. 38
The most common complication of pregnancy is diabetes. It is estimated that 1 in 6 pregnancies are affected (16.6%), with 84% of diabetic pregnancies being affected by Gestational Diabetes Mellitus (GDM)1 . More than 15 years ago, the evidence was cl
Autor:
Catriona Reddin, Declan Devane, Esther Macken, Michael Maresh, Tomás P. Griffin, Linda Biesty, Caroline A Crowther, Mireille N M van Poppel, Mary R. Loeken, Aoife M. Egan, Eugene M. Dempsey, Sander Galjaard, Eoin Noctor, Eleni Anastasiou, Angela Napoli, Paula M O'Shea, Harold W. de Valk, Delia Bogdanet, Andrea Agostini, Shakila Thangaratinam, Narjes Fhelelboom, Fidelma Dunne, Cheril Clarson
Publikováno v:
Diabetologia
Paediatrics Publications
Diabetologia, 62(11), 2007-2016. Springer-Verlag
Paediatrics Publications
Diabetologia, 62(11), 2007-2016. Springer-Verlag
Aims/hypothesis Gestational diabetes mellitus (GDM) is linked with a higher lifetime risk for the development of impaired fasting glucose, impaired glucose tolerance, type 2 diabetes, the metabolic syndrome, cardiovascular disease, postpartum depress
Autor:
Isabel Sánchez-Vera, Esther Carrera, Marta Viana, Mary R. Loeken, Fabiola Alvarez-Gallego, Martín Alcalá, Guillermo T. Sáez, Victoria E. Bolado, Francisco Dasí, Sonia Clapés
Publikováno v:
Antioxidants; Volume 10; Issue 8; Pages: 1173
Antioxidants
Antioxidants, Vol 10, Iss 1173, p 1173 (2021)
Antioxidants
Antioxidants, Vol 10, Iss 1173, p 1173 (2021)
Congenital malformations are a common adverse outcome in pregnancies complicated by pregestational obesity, although the underlying mechanisms are still unrevealed. Our aim was to study the effect of oxidative stress in obesity-induced teratogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d27b9808e87d6a18e6341be9b5b277
http://hdl.handle.net/10637/14544
http://hdl.handle.net/10637/14544
Autor:
Mary R. Loeken
Publikováno v:
Curr Diab Rep
PURPOSE OF REVIEW: Fetuses of diabetic mothers are at increased risk for congenital malformations. Research in recent decades using animal and embryonic stem cell models has revealed many embryonic developmental processes that are disturbed by matern
Autor:
Eleni Anastasiou, Sander Galjaard, Declan Devane, Marie Todd, Harold W. de Valk, Valerie Smith, Fidelma Dunne, Michael Maresh, Aoife M. Egan, Angela Napoli, Mireille N M van Poppel, Eoin Noctor, Mary R. Loeken
Publikováno v:
Egan, A M, Galjaard, S, Maresh, M J A, Loeken, M R, Napoli, A, Anastasiou, E, Noctor, E, de Valk, H W, van Poppel, M, Todd, M, Smith, V, Devane, D & Dunne, F P 2017, ' A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes ', Diabetologia, pp. 1-7 . https://doi.org/10.1007/s00125-017-4277-4
Diabetologia
Diabetologia, 60(7), 1190-1196. Springer-Verlag
Diabetologia
Diabetologia, 60(7), 1190-1196. Springer-Verlag
Aims/hypothesis The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus. Methods A systematic literatu
Autor:
Dan Wei, Mary R. Loeken
Publikováno v:
Diabetes
Previous studies have shown that diabetic embryopathy results from impaired expression of genes that are required for formation of embryonic structures. We have focused on Pax3, a gene that is expressed in embryonic neuroepithelium and is required fo
Publikováno v:
Diabetes/Metabolism Research and Reviews. 30:23-30
Background Adenosine monophosphate-activated protein kinase (AMPK) is stimulated in embryos during diabetic pregnancy by maternal hyperglycaemia-induced embryo oxidative stress. Stimulation of AMPK disrupts embryo gene expression and causes neural tu
Autor:
Robert S. Lindsay, Mary R. Loeken
Publikováno v:
Diabetologia
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies. In early years, perceived safety concerns